Applied

Therapeutics

The Clinical Use of Drugs

TENTH EDITION

Edited By

Brian K. Alldredge, PHARMD

Professor of Clinical Pharmacy and Associate

Dean, Academic Affairs

Department of Clinical Pharmacy

School of Pharmacy

University of California, San Francisco

San Francisco, California

Robin L. Corelli, PHARMD

Professor of Clinical Pharmacy

Department of Clinical Pharmacy

School of Pharmacy

University of California, San Francisco

San Francisco, California

Michael E. Ernst, PHARMD, BCPS, FCCP

Professor (Clinical)

Department of Pharmacy Practice and Science

College of Pharmacy

Department of Family Medicine

Carver College of Medicine

The University of Iowa

Iowa City, Iowa

B. Joseph Guglielmo, PHARMD

Professor and Chair

TA Oliver Chair in Clinical Pharmacy

Department of Clinical Pharmacy

School of Pharmacy

University of California, San Francisco

San Francisco, California

Pamala A. Jacobson, PHARMD

Associate Professor

Department of Experimental and Clinical Pharmacology

College of Pharmacy

University of Minnesota

Minneapolis, Minnesota

Wayne A. Kradjan, PHARMD, BCPS

Dean Emeritus and Professor Emeritus

College of Pharmacy

Oregon State University

Oregon Health & Science University

Corvallis, Oregon

Bradley R. Williams, PHARMD, FASCP, CGP

Professor of Clinical Pharmacy and Clinical Gerontology

Titus Family Department of Clinical Pharmacy and

Pharmaceutical Economics and Policy

Schools of Pharmacy and Gerontology

University of Southern California

Los Angeles, California

Acquisitions Editor: David B. Troy

Project Manager: Meredith L. Brittain

Marketing Manager: Joy Fisher-Williams

Designer: Doug Smock

Compositor: Aptara, Inc.

c 2013, 2009, 2005 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business

Two Commerce Square

2001 Market Street

Philadelphia, PA 19103 USA

LWW.com

Tenth Edition

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any

form by any means, including photocopying, or utilized by any information storage and retrieval system

without written permission from the copyright owner, except for brief quotations embodied in critical

articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties

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Printed in China

Library of Congress Cataloging-in-Publication Data

Koda-Kimble and Young’s applied therapeutics : the clinical use of drugs.

– 10th ed. /edited by Brian K. Alldredge . . . [et al.].

p. ; cm.

Applied therapeutics

Rev. ed. of: Applied therapeutics : the clinical use of drugs /edited

by Mary Anne Koda-Kimble ... [et al.]. 9th ed. c2009.

Includes bibliographical references and index.

ISBN 978-1-60913-713-7

I. Koda-Kimble, Mary Anne. II. Alldredge, Brian K. III. Applied therapeutics.

IV. Title: Applied therapeutics.

[DNLM: 1. Drug Therapy–methods. WB 330]

615.5

8–dc23

2011047631

Care has been taken to confirm the accuracy of the information presented and to describe generally

accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions

or for any consequences from application of the information in this book and make no warranty, expressed

or implied, with respect to the currency, completeness, or accuracy of the contents of the publication.

Application of the information in a particular situation remains the professional responsibility of the

practitioner.

The authors, editors, and publisher have exerted every effort to ensure that drug selection and

dosage set forth in this text are in accordance with current recommendations and practice at the time of

publication. However, in view of ongoing research, changes in government regulations, and the constant

flow of information relating to drug therapy and drug reactions, the reader is urged to check the package

insert for each drug for any change in indications and dosage and for added warnings and precautions.

This is particularly important when the recommended agent is a new or infrequently employed drug.

Some drugs and medical devices presented in the publication have Food and Drug Administration

(FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care

provider to ascertain the FDA status of each drug or device planned for use in their clinical