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Liver and gall bladder

Inferior view, posterior at top

Besides pancreatic juice, the other secretory product emptied into the duodenum is bile. The biliary system, which

Liver and Gallbladder

also develops as an embryonic outgrowth of the duodenum, includes the liver, the gallbladder, and

associated ducts. The rounded, wedge-shaped liver, the largest organ of the abdomen, occupies a

major portion of the upper right peritoneal cavity. The gallbladder is a pear-shaped, saccular organ situated in a depression on the inferior surface of the right lobe of the liver where it is a storage organ of the

bile that is produced in the liver. Connecting the gallbladder to the common hepatic bile duct is the cystic

bile duct. The junction of these ducts forms the main bile duct that drains into the duodenum. The liver

is the largest and most important metabolic organ in the body, which in addition to producing the important bile salts associated with digestion, performs a myriad of metabolic functions.

 1 Right lobe of liver

 2 Left lobe of liver

 3 Caudate lobe of liver

 4 Quadrate lobe of liver

 5 Gallbladder

 6 Cystic bile duct

 7 Hepatic artery

 8 Hepatic portal vein

 9 Round ligament

10 Inferior vena cava

 11 Hepatocytes

12 Central vein

13 Hepatic sinusoid

14 Branch of hepatic artery

15 Bile duct

16 Branch of hepatic portal vein

Photomicrograph of liver lobule

50x

Photomicrograph of portal triad

150x

Photomicrograph of central vein

100x

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 1 Cecum

 2 Vermiform appendix

 3 Ascending colon

 4 Right colic (hepatic) flexure

 5 Transverse colon

 6 Left colic (splenic) flexure

 7 Descending colon

 8 Sigmoid colon

The large intestine is much shorter than the small intestine,

averaging about 1.5 meters in length, but typically has a greater

diameter, therefore the name. The large intestine consists of

Large Intestine

 9 Rectum

10 Omental or fatty appendices

 11 Haustra

12 Taeniae coli

13 Absorptive cells

14 Goblet cells

15 Intestinal glands

16 Muscularis mucosae

the cecum, appendix, colon, and rectum. The cecum receives indigestible material from the small intestine and

then moves it through the subdivisions of the colon — the ascending colon, transverse colon, descending

colon, and sigmoid colon — before it enters the terminal portion of the gut tube, the rectum. The large intestine

is primarily a drying and storage organ of indigestible plant fi bers. Minimal absorption of fl uids occurs in the

large intestine as the fecal contents are stored prior to evacuation.

17 Lamina propria

18 Tela submucosa

19 Ileum (cut)

20 Duodenal-jejunal junction (cut)

21 Stomach

22 Root of the mesentery (cut)

Portion of descending colon

Anterior view

Dissection of abdominal cavity with jejunum and ileum removed

Anterior view

Photomicrograph of of large

intestine mucosa

100x

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Sagittal section of head and trunk

Medial view

Dissection of the mesentery with jejunum and ileum removed

Anterior view

 1 Transverse mesocolon

 2 The mesentery partially dissected to reveal vessels

 3 Greater omentum

 4 Superior mesenteric vein and tributaries

 5 Branches of superior mesenteric artery

 6 Cecum

 7 Ascending colon

 8 Transverse colon

 9 Gallbladder

10 Cystic bile duct

 11 Common hepatic bile duct

12 Common bile duct

13 Omental or fatty appendices

14 Stomach

15 Small intestine

16 Aorta

Mesenteries are refl ections of the serous peritoneal membrane from the parietal layer

lining the posterior abdominal wall to the visceral layer covering the peritoneal abdominal

organs. The mesenteries not only support the digestive organs and help anchor them in

Mesenteries

the abdominal cavity, but also are the pathways for the vessels and nerves that supply the peritoneal organs.

17 Heart

18 Vertebral column

19 Trachea

20 Aortic arch

21 Pulmonary trunk

22 Brain

23 Tongue

24 Sternum

25 Rectum

26 Bladder

27 Prostate

28 Testis

29 Penis

30 Pubic symphysis

31 Diaphragm

32 Esophagus

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Omenta are mesenteric structures that unite two digestive organs. These refl ections of the peritoneal membrane course from one abdominal digestive organ to another abdominal digestive organ,

rather than from organ to body wall. There are two omenta in the abdominal cavity. The greater

Omenta

Superfi cial dissection of abdominal cavity with liver elevated

Antero-inferior view

omentum is a peritoneal refl ection between the greater curvature of the stomach and the transverse colon. The lesser

omentum is a peritoneal refl ection between the lesser curvature of the stomach and the liver.

 1 Greater omentum

 2 Lesser omentum

 3 Hepatogastric ligament of lesser omentum

 4 Hepatoduodenal ligament of lesser omentum

 5 Hepatorenal part of coronary ligament

 6 Falciform ligament

 7 Transverse mesocolon

 8 Liver

 9 Stomach

10 Duodenum

 11 Transverse colon

12 Fossa for removed gallbladder

13 Gallbladder

14 Common hepatic bile duct

15 Common bile duct

16 Caudate lobe of liver

17 Lung

18 Heart

19 Breast

20 Diaphragm

21 Epiploic foramen

22 Spleen

Dissection of abdominal cavity with

anterior aspect of liver removed

Antero-inferior view

Dissection of abdominal cavity with

Anterior body wall removed exposing body cavity

Anterior view

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REAL ANATOMY

313

Like the respiratory and digestive systems, the urinary system is an environmental

 exchange system. Like all the exchange systems of the body, the urinary system forms an immense interface with the cardiovascular system for the single purpose of regulating the homeostatic balance of the water environment (extracellular matrix)

that surrounds every cell in the body. To make this exchange possible a

large network of microscopic urinary tubes form an intimate

 interface with an equally large network of cardiovascular

capillaries. Th e urinary system consists of two

blood processing centers called the kidneys, two

transport tubes called the ureters, a storage

 organ called the bladder, and a drain called the

urethra. Th e kidneys continually produce

urine, which is then moved via the

 ureters to the storage organ, the bladder.

When it is convenient to remove the

urine from the body, contractions in

the wall of the bladder expell the

urine through the urethra.

In order to survive, every

body cell requires a water environment that is similar to the composition of the oceans in which

 cellular life fi rst arose. Th e kidneys

help maintain this intercellular

 water environment by fi ltering the

blood and regulating its contents

so the blood can help maintain

the correct composition of the

 extracellular fl uid that bathes every

cell. By adjusting the amount of

water in the plasma and the various

plasma constituents, which are

 either conserved for the body or

eliminated in the urine, the kidneys

are able to maintain water and

electrolyte balance within the very

narrow range compatible with life,

despite wide variations in intake

and losses of these constituents

through other avenues.

Find more infomation

about the urinary

system in

19 Urinary System


314

retroperitoneal and subperitoneal spaces in the abdominopelvic cavity, where they are

surrounded by a large amount of adipose tissue and some areolar connective tissue. The

dissection images on this and the facing page depict the organs of the urinary system

and their relations to other organs in the abdominopelvic cavity.

The organs of the urinary system include

the paired kidneys, paired ureters, bladder,

and urethra. The urinary organs occupy the

Urinary Organs

 1 Kidney

 2 Renal pelvis

 3 Ureter

 4 Bladder

 5 Renal vein

 6 Renal artery

Dissection of the retroperitoneal space of the abdominal cavity

Anterior view

 7 Adrenal gland

 8 Aorta

 9 Inferior vena cava

10 Diaphragm

 11 Common iliac artery

12 Psoas major muscle

13 Liver

14 Lumbar vertebra

15 Hilum

16 Perirenal fat

17 Intestines

18 Mesenteric fat

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Transverse section of abdomen at level of fi rst lumbar vertebra

Inferior view

Dissection of abdomen showing perirenal fat

Anterior view

Level of section

Transverse section of abdomen through kidneys

Inferior view

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The lungs are the spongy, pyramidal-shaped organs that house the bronchial

tree and the extensive pulmonary vascular network. Each lung is surrounded

by a thin mesothelial covering, the visceral pleura, and sits on either side of

Lungs

the heart within the thoracic cavity. The vascular and respiratory passageways enter each lung on

its medial aspect at the hilum. The wide base of the lung sits on the diaphragm inferiorly and

tapers to a narrow apex superiorly. The right lung has three lobes and the left lung two lobes.

Right lung

Lateral view, anterior to the right

Right lung

Medial view, anterior to the left

Photomicrograph of lung tissue

100x

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 1 Apex

 2 Superior lobe

 3 Middle lobe

 4 Inferior lobe

 5 Oblique fissure

 6 Transverse fissure

 7 Segmental (tertiary) bronchus

 8 Pulmonary artery

 9 Pulmonary vein

10 Costal impression

 11 Diaphragmatic surface

12 Aortic impression

13 Cardiac notch

Left lung

Lateral view, anterior to the left

Left lung

Medial view, anterior to the right

Photomicrograph of lung tissue

100x

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16 Small artery

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18 Blood vessels with rbcs

19 Lingula

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Cast of Trachea and Bronchial Tree

Latex cast of respiratory passageways of trachea and lungs of a dog

Anterior view at left, posterior view at right

 1 Trachea

 2 Right main (primary) bronchus

 3 Left main (primary) bronchus

 4 Lobar (secondary) bronchus

 5 Segmental (tertiary) bronchus

 6 Branching bronchiole network

The cast below is from a large dog’s lungs and is approximately the same size as human lungs. The casts were created by

forcing liquid latex into the respiratory passageways of the lungs and then letting the latex harden. The lungs were then

placed in a weak acid until the organic tissue of the lungs was digested away. These views of the cast allow you to visualize

the extensive nature of the bronchial tree as it branches out to the larger alveolar passageways within the lungs. The

smaller alveolar spaces did not get incorported into the casts.

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REAL ANATOMY

18 Digestive System

Th e digestive system is the extensive environmental interface that makes

it possible to transfer nutrients, water, and electrolytes

from the food we eat into the body’s internal environment. Th is is made possible by a complex lining,

which through a series of folds and a variety of small

to microscopic projections greatly increases the surface interface between the digested contents within

the gastrointestinal organs and the numerous small

capillaries beneath this lining. To better appreciate

the degree of this surface increase, realize that the

average total surface area of the skin of an adult

 human is about 20 square feet, while the surface

area of the digestive system is approximately 2,500

square feet, or about the size of a tennis court. To

make the transfer across this extensive surface area

possible, the food we eat must be broken down

into small molecules that can be absorbed from the

digestive tract into the circulatory system, which

then distributes the molecular metabolites to the

cells. Th erefore, the digestive organs also function in

the mechanical and chemical breakdown of the food.

Developmentally the digestive system begins as a

simple tube called the gut tube or gut. As this simple

tube develops into the highly convoluted organs of the

adult anatomy, it undergoes structural changes that account for its various functions. Th ough these structural

changes lead to diff erences in the tube from one region to

the next, there is a basic pattern of design throughout the

length of the tube. Th is structural pattern is responsible for

the general function of the digestive system. Modifi cations of

this pattern allow for the variation in structure and function

along its length. Th is chapter will highlight the structural variation and underlying design of the digestive system.

Find more information

about the digestive

system in

299


300

Superfi cial dissection of abdominal viscera

Anterior view

Intermediate dissection of abdominal viscera

Anterior view

The digestive system begins at the mouth, where

food and drink enter this tubular organ system to be

processed by the teeth and tongue. From the mouth

Digestive System Organs

the broken-down food moves through the transport tube called the esophagus to the storage and mixing organ called the

stomach. The stomach thoroughly mixes digestive juices and mucous with the food as it tosses it around to produce a softened substance called chyme. The chyme is slowly moved into the small intestine where powerful digestive chemicals are

added from the pancreas. As the chyme slowly moves through the long small intestine, the digestive enzymes break it into

small metabolic fuel molecules that the intestine absorbs. The material that cannot be digested and absorbed is passed into

the large intestine where the nondigested remains are held until they can be removed through the anus as feces. The photos on this and the facing page depict the digestive organs and their related mesenteries.

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Intermediate dissection of abdominal viscera

Anterior view

Deep dissection of abdominal viscera

Anterior view

 1 Esophagus

 2 Stomach

 3 Liver

 4 Gallbladder

 5 Pancreas

 6 Duodenum

 7 Jejunum

 8 Ileum

 9 Cecum

10 Ascending colon

 11 Transverse colon

12 Descending colon

13 Rectum

14 Greater omentum

15 Lesser omentum

16 Mesentery

17 Transverse mesocolon

18 Lungs

19 Heart

20 Diaphragm

21 Aorta

22 Spleen

23 Trachea

24 Inferior vena cava

25 Kidney

26 Bladder

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Photomicrograph of small intestine wall

40x

The wall of the digestive tract has a basic pattern of

design  that is found throughout its length. This pattern

consists of three tunics or layers of anatomy. The tunica

Design of the Gut Wall

mucosa and its subdivisions, including the tela submucosa, form the inner layer of the wall and consist of an extensive

epithelial lining with an underlying vascullar connective tissue. The middle layer, or tunica muscularis, consists of smooth

muscle that provides for the varied types of movements that occur within the digestive organs. The majority of the organs

have an outer layer, the tunica serosa, comprised of a lubricated meosthelial membrane that reduces friction as the organs

move against one another. The image below, from the small intestine, illustrates the basic layers of the digestive tract wall.

Tunica mucosa

consisting of:

epithelium,

lamina propria,

and

muscularis

mucosae

Tunica serosa

Tela

submucosa

Tunica muscularis

circular layer

Tunica muscularis

longitudinal layer

 1 Simple columnar epithelium

 2 Lamina propria

 3 Muscularis mucosae

 4 Submucosal (Brunner’s) glands

 5 Villi

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 1 Lips

 2 Teeth

 3 Tongue

 4 Hard palate

 5 Soft palate

 6 Nasopharynx

 7 Oropharynx

 8 Laryngopharynx

 9 Parotid gland

10 Submandibular gland

 11 Parotid duct

12 Serous acini

13 Mucous acini

14 Vein

15 Trabecula

16 Masseter

17 Sternocleidomastoid

18 Sphenoid sinus

19 Epiglottis

20 Vertebral column

21 Cerebrum

22 Spinal cord

Dissection of head showing salivary glands

Lateral view

Sagittal section of head and neck

Medial view

The mouth, or oral cavity, is the entryway into the digestive system.

In addition to serving as the portal to the tubular gut, the mouth

contains structures, such as the tongue, teeth, and salivary glands,

Mouth and Pharynx

that help initiate the digestive process. The boundaries of this region are defi ned by the lips and cheeks, which form the

anterior and lateral walls, the palate, which forms the roof, and numerous muscles, the most conspicuous being the muscles

of the tongue, which form the fl oor of the mouth. The pharynx is the fi rst portion of the gut tube and is divided into three

regions. Each region communicates with a different cavity — the nasopharynx with the nasal cavity, the oropharynx with the

oral cavity, and the laryngopharynx with the cavity of the larynx.

Photomicrograph of submandibular gland

240x

Photomicrograph of parotid gland

100x

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304

Pharynx, esophagus, and stomach

Anterior view Photomicrograph of esophageal wall

40x

Step dissection of esophagus

Anterior view

Below the laryngopharynx the gut tube branches into an anterior respiratory tube, the larynx and a posterior digestive tube, the esophagus.

The esophagus is a narrow, collapsed muscular tube coursing from the

Esophagus

laryngopharynx to the stomach. It is approximately 25 cm in length and begins near the level of the sixth

cervical vertebra, where it runs inferiorly against the anterior surface of the thoracic vertebral column.

At the level of the tenth thoracic vertebra it deviates slightly to the left passing through the esophageal

hiatus of the diaphragm to enter the stomach. It functions as a muscular tube of transmission.

 1 Esophagus

 2 Tunica mucosa

 3 Tela submucosa

 4 Tunica muscularis circular layer

 5 Tunica muscularis longitudinal layer

 6 Stratified squamous epithelium

 7 Lamina propria

 8 Muscularis mucosae

 9 Tunica adventitia

10 Stomach

 11 Pharynx - dorsal wall

12 Vagus nerve

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Frontal section of stomach

Anterior view Photomicrograph of stomach mucosa

with callout above

40x and 100x

 1 Stomach

 2 Cardia of stomach

 3 Fundus of stomach

 4 Body of stomach

 5 Pyloric antrum

 6 Pyloric canal

The stomach is a J-shaped organ of variable size and shape and has the greatest diameter of any part of the gut tube. It occupies the upper left quadrant of

the abdominal cavity, where it is anchored to the posterior abdominal wall by a

Stomach

 7 Pylorus

 8 Pyloric sphincter

 9 Gastric rugae

10 Greater curvature

 11 Lesser curvature

12 Gastric pit

mesentery. The stomach performs several functions, the most important of which is to store ingested food

until it can be emptied into the small intestine at a rate that allows for optimal digestion and absorption.

13 Surface mucous cell

14 Lamina propria

15 Mucous neck cell

16 Gastric glands

17 Liver

18 Gallbladder

19 Spleen

20 Greater omentum

Abdominal dissection revealing stomach

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Small intestine in situ

Anterior view

The small intestine is a highly coiled tube with a fairly consistent diameter from beginning to end. It is approximately

6 to 7 meters long in the cadaver but, because of its muscle

Small Intestine

tone only around 4 to 5 meters in the living. The small intestine occupies the greater part of the mid- to

lower abdominal cavity and consists of three regions. The retroperitoneal fi rst part is called the duodenum and is about 30 cm in length. This C-shaped region receives the secretions from the pancreas and

liver. The remaining parts of the small intestine are the jejunum and ileum, which make up the bulk of

the organ and are attached to the posterior wall of the abdomen by the mesentery. The small intestine

is the principal site of digestion and absorption.

Sectioned small intestine

revealing circular folds

Internal view

Entire small intestine sectioned to show changes in

internal surface from the duodenal end to the ileal end

Internal view

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Loop of small intestine from unembalmed cadaver, opened to show circular folds

Anterior view

Loop of small intestine

Anterior view

 1 Duodenal end

 2 Ileal end

 3 Jejunum

 4 Ileum

 5 Circular folds

 6 Simple columnar epithelium

 7 Goblet cell

 8 Lamina propria

 9 Liver

10 Stomach

 11 Cecum

12 Transverse colon

13 Descending colon

14 Mesentery

15 Microvillus brush border

Photomicrograph of cross-section of intestinal villus

400x

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 1 Tail of pancreas

 2 Body of pancreas

 3 Head of pancreas

 4 Uncinate process of pancreas

 5 Pancreatic duct (of Wirsung)

 6 Major duodenal papilla

 7 Exocrine acinus

 8 Pancreatic ductule

 9 Pancreatic islet (endocrine cells)

10 Trabecula

 11 Duodenum

12 Liver

13 Gallbladder

14 Common bile duct

15 Spleen

16 Diaphragm

The pancreas is a pinkish glandular structure situated posterior to the stomach

in the retroperitoneal space of the abdominal cavity. It arises as an outgrowth

of the duodenum during development and retains this connection via the panPancreas

creatic duct. It is a dual glandular organ consisting of both exocrine and endocrine glandular tissue. It has

four basic regions: a head, neck, body, and tail. The exocrine glands and ducts produce and deliver the

powerful digestive enzymes to the small intestine.

Photomicrograph of pancreas

100x

Abdominal dissection with part of liver

and peritoneal organs removed

Anterior view

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