12/10/21

يسبب إعطاء دواء Diltiazem مع Simvastatin ما يسمى ب "Frozen shoulder"

والذي يتمثل بآلام شديدة في العنق و الكتف .

  السبب : 

- دواء Simvastatin من عائلة Statins من أعراضه الجانبية آلام عضلية "muscle pain"

- عند مشاركته مع Diltiazem   يثبط استقلاب Simvastatin بالكبد !

  ارتفاع مستويات Simvastatin  بالدم  .

  زيادة آثاره الجانبية و احتمال حدوث ضعف بالعضلات . 

-

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