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p. 2288

Note: Page number followed by f and t indicates figures and tables respectively

Abacavir (ABC), 58t, 1616

for HIV, 1577t

Abatacept, 881, 883, 896t, 897, 898, 904

Abciximab, 22

for ACS, 237

Abilify (see Aripiprazole)

Abiraterone, 2095, 2096

Abreva (see Docosanol cream)

Acamprosate, 1898–1899

Acarbose, for type 2 diabetes, 1125, 1126, 1134

ACE inhibitors (see Angiotensin-converting enzyme (ACE) inhibitors)

Acetaldehyde, 1892

Acetaminophen, 44, 49, 1182, 1183, 1185, 1187t, 1191, 1982t

analgesic syndrome from, 601

for arthritis, 2228

for burns, 863

for dysmenorrhea, 1015

for end-of-life care, 86

for HAV, 1665

hepatitis and, 1672

for migraine headache, 1237

neonates and, 2157, 2165, 2166

for OA, 867, 869

for PDA, 2181

PegIFN therapy, 1678

for postoperative pain management, 1180

pregnancy and, 79, 942t

toxicity with, 79–82

Acetazolamide, 564, 581

cryptococcal disease, 1643

and hypokalemia, 583t

Acid-related disorders, pharmacotherapy of drugs

antacids and alginic acid, 482, 484

bismuth salts, 486

-receptor antagonists, 484

misoprostol, 486

PPI, 484–486

sucralfate, 486

Acitretin, for psoriasis, 836t, 840

Aclidinium bromide, for COPD, 420t

Acular (see Ketorolac)

Acupressure, 975

Acupuncture, 975

ACV (see Acyclovir (ACV))

Acyclovir (ACV), 744, 1648t, 1650

administration of, 1650

adverse effects of, 1334t, 1647, 1647t

dosing of, 1336t

for genital herpes, 1529, 1530t

for herpes encephalitis, 1646–1647

for herpes labialis, 1650–1651

for herpes simplex virus, 1167–1168, 1648, 1650

oral administration, 1647–1648

pharmacokinetics of, 1653t

for PHN, 1652, 1654

renal failure, dosing of drugs, 672–673

toxicity, 1654–1655

against varicella infection, 1652

Acyclovir and Hydrocortisone cream (Xerese), 1650

Acyclovir cream (Zovirax), 1650

ADACEL, 1357

Adalimumab, 881, 895, 896t, 904

for inflammatory bowel disease, 522t

for PsA, 842–843

for RA, 882

for UC, 527–528

Adapalene, 827, 828, 829, 830

Adefovir dipivoxil, 1678

Adenosine, 319–320

Ado-trastuzumab emtansine, 469t

Adrenaclick, 446t

Aerosolized aztreonam, 460

Afatinib, 470t

Aflibercept, 1169

Afrezza, 1084, 1086

Afrin (see Oxymetazoline)

Aggressive insulin therapy, 453

Akynzeo (see Palonosetron; Netupitant)

Alanine aminopeptidase, 1990

Albendazole, 1705t

for ascariasis, 1703t

for enterobiasis, 1703t

for filariasis, 1704t

for giardiasis, 1704t

for hookworm, 1704t

for hydatid cysts, 1705t

for pinworm, 1708

Albiglutide, 1126–1127

Albumin, 358

in edema, 573

Albuterol, 392, 689t

for acute asthma, 388

for AECOPD, 1408

anxiety from, 1736t

for chronic asthma, 395

Alocril (see Nedocromil)

Alogliptin, 1127–1128

Alomide (see Lodoxamide)

Alosetron, 536

Aloxi (see Palonosetron)

α-adrenergic agonists, 503t

α-adrenergic blockers, 2242

α-blockers, 157–158

with β-blockers, 158–159

for hypertension, 140

Alphagan (see Brimonidine)

α2

-adrenergic agonist, 1878

α2

-agonists

for ADHD, 1870

for developmental disorders, 1855–1856

for hypertension, 159

Alprazolam (Xanax), 1027t, 1271t, 1272, 1737t, 1759

drug interaction with smoking, 1906t

for panic disorder, 1748

for PMDD, 1025

sedative-hypnotics, 1882

Alprostadil, 2266

Alrex (see Loteprednol)

Alteplase, for STEMI patients, 237

Altretamine, 470t

Aluminum hydroxide, 620t

Aluminum salts, 482, 917t

Amantadine (Symmetrel), 1224, 1250t, 1262, 1649t

adverse effects, 1647t

for Akathisia, 1800t

for influenza, 1655–1656

for Parkinsonism, 1799

pharmacokinetics of, 1653t

AmB (see Amphotericin B (AmB))

AmB formulation, 1643

Ambien, 1767t

Ambien CR, 1767t

Ambrisentan, 128, 924

Ameliorate, 1878

Amifostine, 469t, 1973–1974

Amikacin (Amikin), 461t, 1325t

adverse effects of, 1332t

for CAPD-associated peritonitis, 1476t

for CNS infections, 1373t

for gram-negative aerobes, 1327t

for MAC, 1619

pharmacodynamic actions of, 48

for tuberculosis, 1430t

for UTI, 1497t

Amikin (see Amikacin)

Amiloride, 543, 580–581

for hypertension, 148

Aminess, 794t

Aminobenzoates, 852

Aminoglycosides, 455, 460, 635–636, 1720

adverse effects of, 1332t

for CNS infections, 1373t

extended-interval dosing of, 461

for NEC, 2183

for neutropenic patients, 1563, 1564

for pneumonia, 1419

renal failure, dosing of drugs, 668–670

for inflammatory bowel disease, 520, 523

Amiodarone, 120t, 214

for ACS, 238t

adverse effects of, 326

for AF, 316–317

antiadrenergic effects of, 326

for cardiopulmonary arrest, 331

for HF, 299–300

and liver toxicity, 326

and MI, 324

for SuVT, 324–325

for tachycardia, 1802

for ventricular arrhythmias treatment, 248

Amitriptyline, 535, 1181t, 1191, 1192, 1194t, 1242, 1245

for depressive disorders, 1819t, 1821t

Amlodipine, 120t, 155, 214

for chronic stable angina pectoris, 214

for vascular dementia, 2242

Ammonia, 822t

Amoxicillin (Amoxil), 493–494t, 496, 917t, 942t, 1326t, 1720, 2165

Amoxicillin/clavulanate

for CAPD-associated peritonitis, 1476t

for COPD, 418

and potassium clavulanate, 1488t

PPI and, 496–497

for skin and soft tissue infections, 1550

for UTI, 1488t

Amoxil (see Amoxicillin)

Amphetamine, 1885, 1868

for ADHD, 1867t

CNS stimulants, 1884

and lactation, 1003t

for schizophrenia, 1783, 1783t

Amphotericin

for CAPD-associated peritonitis, 1476t

and hypokalemia, 583t

nephrotoxicity by, 1400

Amphotericin B (AmB), 675, 1624, 1624t, 2009

5-FC and, 1400

adverse effects of, 1334t, 1632–1634

for aspergillosis, 1640–1641

candida infections

AmB-associated renal dysfunction, 1633

dose and duration of therapy, 1632

infusion-related reactions, 1632–1633

for cryptococcal meningitis, 1614–1615

dose and duration of therapy, 1629t, 1632

every-other-day regimens, 1632

formulations, 1635t

for histoplasmosis, 1637

intrathecal administration of, 1640

for leishmaniasis, 1705t

risk factor B, 1637

for sepsis, 2186t

Amphotericin B deoxycholate (AmBD), 1568

Ampicillin (Omnipen), 917t, 942t, 1326t, 2131t

for aerobic gram-positive cocci, 1326t

allergy, 684

for anaerobes, 1328t

for CAPD-associated peritonitis, 1476t

for chorioamnionitis, 996

for CNS infections, 1373t

dosing of, 1336t

for enterococcal endocarditis, 1397t

for gram-negative aerobes, 1327t

for NEC, 2183

for sepsis, 2186, 2186t

for UTI, 1488t, 1497t

Ampicillin-sulbactam

for CAPD-associated peritonitis, 1476t

for chorioamnionitis, 996

dosing of, 1336t

for UTI, 1497t

Amprenavir, 128, 942t

Amylase, and respiratory alkalosis, 1672

Amylin receptor agonists

adverse effects of, 1129

contraindications and precautions of, 1129

dosage and clinical use, 1129

drug interactions, 1129

efficacy of, 1129

mechanism of action, 1129

pharmacokinetics of, 1129

Anabolic steroids, for acne, 827

Anakinra, 881, 882–883, 896t, 903

Analgesics

for acute gout, 913

for burn pain, 863

drug interactions with, 1190t

for pain management, 1187t

for tension-type headache, 1245

Anastrozole, 1013

Ancef (see Cefazolin)

Androgen deprivation therapy (ADT), 2090

Androgen receptor antagonists for acne, 829

Androgens

for acne, 827

teratogenic effects, 973t

Anesthesia, 2107

Angiotensin-converting enzyme (ACE) inhibitors, 257, 694–695, 917t, 1207

for ACS, 238t

agents of choice, 279–282, 280f

angioedema and, 285, 695, 823

angiotensin receptor blockers and, 270–271, 282–284

and hydralazine–isosorbide, 294–295

hyperkalemia and, 285

for hypertension, 139, 149t, 152–154

induced cough, 284–285

kidney function and, 285–286

left ventricular dysfunction and, 147

for PAD, 167

for patients with CKD, 617

for pregestational diabetes, 979

pregnancy and, 154

side effects of, 285–286

teratogenic effects, 973t

Angiotensin receptor blockers (ARBs), 213, 236, 267, 694–695, 984, 1207

for ACS, 238t

and angioedema, 285, 695

CAD and, 147

chronic kidney disease and, 147

diabetes and, 146

in HF, 282–284, 283t

for hyperkalemia, 285

for hypertension, 139–140, 149t, 154, 154t

and kidney function, 285–286

left ventricular dysfunction and, 147

side effects of, 285–286

Angiotensin receptor-neprilysin inhibitor (ARNI), 273

Anidulafungin, 1624t, 1625

adverse effects of, 1334t

Antacids, 482, 484, 713, 918t, 1974, 1975, 1976

for dyspepsia, 488

and fluoroquinolones, 41

for GER, 2162, 2163t

for GERD, 508

in preventing SRMB, 514, 515t

Anthracycline, 469t, 1981t, 1982t

Anthralin, for psoriasis, 835t, 837

Anthranilates, 849t, 852

Antiandrogen (see Spironolactone)

Antibiotics, 460, 524

for acne, 828

oral, 828

topical, 828

for acute bronchitis, 1406t

adverse effects of, 1332–1334t

for AECOPD, 1408–1409

for biliary infections, 1472–1473

in brain abscess, 1382

for Campylobacter infection, 1459

for CAP, 1412–1414

for CAPD-associated peritonitis, 1476t

for Chlamydia trachomatis, 927

for chorioamnionitis, 996

for chronic S. typhi carriers, 1456–1457

for CNS infections, 1373t

combination therapy, 1341

with corticosteroids, 819

costs of, 1335

CSF penetration characteristics of, 1371t

diarrhea from, 1463

dosing of, 460–462, 1335–1340, 1336–1339t

drug selection, 460

failure with, 1341–1342

for GBS infection, 995

for hospital-acquired pneumonia, 1417–1420

host factors and, 1342

for infectious diarrhea, 1449–1450

for Lyme disease, 1720

for nontyphoidalsalmonellosis, 1453

for nosocomial UTI, 1497t

pharmacokinetics/pharmacodynamics of, 1340–1341

pharmacologic factors, 1341–1342

for PPROM, 995

and protein binding, 1341

for pyelonephritis, 1495–1496

for relapsed UTI, 1498

resistance rates, 497

route of administration, 1335

for SARS, 1660

in SBP treatment, 1474

for shigellosis, 1457

STEC treatment and, 1463

for surgery, 1343–1349

for travelers’ diarrhea, 1459–1460

for typhoid fever, 1456

for UTI, 1486–1494

for V. cholerae infections, 1451

for V. parahaemolyticus gastroenteritis, 1452

Anticholinergics, 1261t

for asthma, 399

for COPD, 421–422

for end-of-life care, 89

GERD and, 503t

for Parkinson’s disease, 1258–1259

for schizophrenia, 1783, 1783t

Anticoagulants, 658, 917t

Anticonvulsants

for brain abscess, 1382–1383

for neuropathic pain, 1188

for PTSD, 1754

Antidepressants, 1778

for bipolar depression, 1847–1848

for patients with abdominal pain, 535–536

and sleep, 1773

toxicity from, 77

tricyclic (see Tricyclic antidepressants)

Antidiarrheals, 536

Antiemetics, 975, 976t, 1240

for CINV, 472–475, 472t

Antiepileptics

for critically ill patients, 1208

for depressive disorders, 1815t

for seizures, 1277t

Antiestrogen (Clomiphene citrate), 959, 1013

for polycystic ovary syndrome, 1012t

Antifungals

adverse effects of, 1334t

antifungalspectrum and susceptibility testing, 1625

for blastomycosis during pregnancy, 1637

cryptococcal disease, 1643

mechanism of action, 1624–1625

novel antifungal compounds, 1625–1626

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