drug
tr
e
a
tme
nt
o
f,
1
4
2
4–
1
4
2
5
e
ld
e
r
ly
a
n
d
,
1
4
3
8
–
1
4
3
9
e
p
id
e
mio
lo
gy
o
f,
1
4
2
2
–
1
4
2
3
e
t
io
lo
gy
o
f,
1
4
2
3
p. 2
3
7
0
p. 2
3
7
1
e
xt
e
n
s
iv
e
ly
drug
-
r
e
s
is
t
a
nt
T
B
(
XD
R
-
T
B
)
,
1
4
2
2
–
1
4
2
3
e
xtr
a
p
ulmo
n
a
ry
,
1
4
4
3
–
1
4
4
4
h
is
t
o
r
y
o
f,
1
4
2
2
H
I
V
a
n
d
,
1
4
4
0–
1
4
4
2
in
c
id
e
n
c
e
o
f,
1
4
2
2
–
1
4
2
3
la
c
t
a
t
io
n
a
n
d
,
1
4
4
3
la
t
e
nt
in
fe
c
t
io
n
a
n
d
,
1
4
2
4
tr
e
a
tme
nt
o
f,
1
4
3
4–
1
4
3
5
mult
idrug
-
r
e
s
is
t
a
nt
T
B
(
M
D
R
-
T
B
)
,
1
4
2
2
,
1
4
3
9
–
1
4
4
0
p
a
th
o
g
e
n
e
s
is
o
f,
1
4
2
4
P
P
D
s
kin
t
e
s
t
fo
r
,
1
4
2
5
–
1
4
2
6
p
r
e
gn
a
n
c
y
a
n
d
,
1
4
4
3
t
o
t
a
lly
drug
-
r
e
s
is
t
a
nt
(
T
D
R
)
,
1
4
2
2
tr
a
n
s
mis
s
io
n
o
f,
1
4
2
3
T
u
b
e
r
c
u
l
o
u
s
m
e
n
i
n
g
i
t
i
s
,
1
4
4
3
–
1
4
4
4
T
u
b
u
l
o
i
n
t
e
r
s
t
i
t
i
a
l
d
i
s
e
a
s
e
s
a
c
ut
e
tub
ula
r
n
e
c
r
o
s
is
,
6
4
1
,
6
4
2
f
a
min
o
g
ly
c
o
s
id
e
-
in
du
c
e
d
A
T
N
,
6
4
4–
6
4
5
,
6
4
4
t
drug
-
in
du
c
e
d
A
T
N
,
6
4
5
r
a
dio
c
o
ntr
a
s
t
me
dia
-
in
du
c
e
d
A
T
N
,
6
4
2
–
6
4
4
,
6
4
3
t
T
u
l
a
r
e
m
i
a
c
linic
a
l
ma
nife
s
t
a
t
io
n
s
,
1
7
2
3
e
p
id
e
mio
lo
gy
,
1
7
2
3
e
t
io
lo
gy
,
1
7
2
3
la
b
o
r
a
t
o
r
y
dia
gn
o
s
is
,
1
7
2
3
–
1
7
2
4
tr
a
n
s
mis
s
io
n
o
f,
1
7
2
3
tr
e
a
tme
nt
,
1
7
2
4
typ
e
A
,
1
7
2
3
typ
e
B
,
1
7
2
3
T
u
m
o
r
l
y
s
i
s
s
y
n
d
r
o
m
e
(
T
L
S
)
,
6
3
6
,
2
0
2
7
T
u
m
o
r
n
e
c
r
o
s
i
s
fa
c
t
o
r
α
(
T
N
F
-
α
)
,
4
9
0
T
.
v
a
g
i
n
a
l
i
s
,
9
9
1
T
yp
e
1
d
i
a
b
e
t
e
s
,
1
0
7
3
t
,
1
0
7
4
,
1
0
7
4
f
β
-
c
e
lls
a
n
d
,
1
0
7
4
b
a
s
a
lb
o
lu
s
in
s
ulin
th
e
r
a
p
y
,
1
0
8
8
–
1
0
9
1
,
1
0
8
9
–
1
0
9
1
t
,
1
0
8
9
f
in
c
h
ildr
e
n
,
1
1
0
1
–
1
1
0
5
c
linic
a
l
p
r
e
s
e
nt
a
t
io
n
o
f,
1
0
7
4
die
t
fo
r
,
1
0
8
0
D
K
A
w
ith
,
1
1
0
1
h
o
n
e
ymo
o
n
p
e
r
io
d
w
ith
,
1
0
7
4
huma
n
le
uko
c
yt
e
a
nt
ig
e
n
(
H
L
A
)
a
n
d
,
1
0
7
4
ke
t
o
n
e
t
e
s
t
in
g
fo
r
,
1
0
8
2
nutr
it
io
n
th
e
r
a
p
y
a
n
d
,
1
0
8
0
p
a
th
o
g
e
n
e
s
is
o
f,
1
0
7
4
,
1
0
7
4
f
p
r
e
v
e
nt
io
n
o
f,
1
0
7
9
–
1
0
8
0
tr
e
a
tme
nt
o
f,
1
0
8
7
–
1
1
0
8
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