ABSTRACT

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies. However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life-threatening complications such as ventricular rupture, cardiac tamponade, and circulatory failure. We present a case series of patients with lymphoma and cardiomyopathy or cardiac metastasis managed with chimeric antigen receptor T-cell therapy. (Level of Difficulty: Advanced.).

PMID:37283829 | PMC:PMC10240233 | DOI:10.1016/j.jaccas.2023.101840

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Informatics tools to implement late cardiovascular risk prediction modeling for population management of high-risk childhood cancer survivors

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