Natus Medical, San Carlos, CA 30 100 420–450 20 462 30 ± 7
Olympic Medical, San Carlos, CA
Olympic Medical, San Carlos, CA
Olympic Medical, San Carlos, CA
Olympic Medical, San Carlos, CA
Rhesus disease, perinatal asphyxia, hypoxia, acidosis, hypercapnia.
From Maisels MJ, Watchko JF. Treatment of jaundice in low birthweight infants.
Arch Dis Child Fetal Neonatal Ed. 2003;88:F459.
b. The pad emits insignificant levels of heat, so it can
be placed in direct contact with the infant to deliver
/nm of spectral irradiance, mainly
c. The orientation of the fiberoptic fibers determines
the uniformity of emission and is unique to each of
the commercially available devices.
d. The main advantages of these systems are that,
while receiving phototherapy, the infant can be held
and/or nursed, thereby minimizing infant–parent
separation. In addition, covering the infant’s eyes is
not necessary, preventing further parental anxiety.
e. The main disadvantage of the fiberoptic pads is that
they cover a relatively small surface area and, therefore, have less efficacy compared to overhead
sources. They should not be used as the sole means
of providing phototherapy in an infant with significant hyperbilirubinemia (1,2,11).
provide “double” phototherapy (circumferential
phototherapy), which has greater efficacy because
greater body surface area is exposed to the light
7. Gallium nitride light-emitting diodes (LEDs)
a. These systems are semiconductor phototherapy
devices capable of delivering high spectral irradiance levels of >200 μW/cm2
infrared emission and no ultraviolet emission
b. LEDs have a longer lifetime (>20,000 hours) and
have become cost-effective for use in phototherapy
devices. LEDs and compact fluorescent tubes are
equally efficacious in the management of hyperbilirubinemia (19).
Intensive phototherapy is defined as the use of light in the
430- to 490-nm band delivered at 30 mW/cm2
to the greatest body surface area possible (1,10).
1. Position the phototherapy unit over the infant to obtain
desired irradiance (10 to 40 μW/cm2
/nm). The maximal amount of irradiance achieved by the standard
technique is generally 30 to 50 μW/cm2
/nm. The distance of the light from the infant has a significant effect
possible to the infant. Fluorescent tubes may be
brought within approximately 10 cm of term infants
Table 49.2 Phototherapy Devices Commonly Used in the United States, and Their
Phototherapy is the most common therapeutic intervention
used for the treatment of hyperbilirubinemia (1).
Phototherapy causes three reactions: configurational and
structural isomerization of the bilirubin molecule and
for conjugation or further metabolism (2).
The aim of phototherapy is to reduce serum bilirubin
levels to decrease the risk of acute bilirubin encephalopathy
the total serum bilirubin (TSB) and decreases the need for
1. Clinically significant indirect hyperbilirubinemia.
risk factors such as acidosis and sepsis (1,4).
2. The TSB level must be considered when making the
decision to commence treatment, as there is significant
variability in laboratory measurement of direct bilirubin levels (5).
3. The American Academy of Pediatrics has published
clinical practice guidelines for phototherapy in
newborn infants at 35 weeks’ or more gestation (1)
4. These guidelines do not apply to preterm infants <35
weeks’ gestation. Preterm infants are at higher risk of
developing hyperbilirubinemia compared to term
infants. Although guidelines have been proposed, the
decision to initiate phototherapy in this group of infants
remains variable and highly individualized (4,6)
1. Congenital porphyria or a family history of porphyria is
an absolute contraindication to the use of phototherapy. Severe purpuric bullous eruptions have been
described in neonates with congenital erythropoietic
4. Although infants with cholestatic jaundice may develop
However, because the products of phototherapy are
excreted in the bile, the presence of cholestasis may
decrease the effectiveness of phototherapy.
1. Spectral qualities of the delivered light (wavelength
range and peak). Bilirubin absorbs visible light within
the wavelength range of 400 to 500 nm, with peak
absorption at 460 ± 10 nm considered to be the most
2. Irradiance (intensity of light), expressed as watts per
photons received per square centimeter of exposed
3. Spectral irradiance is irradiance that is quantitated
within the effective wavelength range for efficacy and is
/nm. This is measured by various
system, because measurements of irradiance may vary
depending on the radiometer and the light source
A variety of phototherapy equipment devices exist
and may be free-standing, attached to a radiant warmer,
wall-mounted, suspended from the ceiling, or fiberoptic
systems. These in turn may contain various light sources
14. Fridkin SK, Hageman JC, Morrison M, et al. Methicillin-resistant
Staphylococcus aureus disease in three communities. N Engl
15. Rudoy RC, Nakashima G. Diagnostic value of needle aspiration
in Haemophilus influenzae type b cellulitis. J Pediatr.1979;94:
17. Jarratt M, Ramsdell W. Infantile acropustulosis. Arch Dermatol.
18. Kahn G, Rywlin AM. Acropustulosis of infancy. Arch Dermatol.
19. Loyer EM, DuBrow RA, David CL, et al. Imaging of superficial
soft-tissue infections: sonographic findings in cases of cellulitis
and abscess. Am J Roentgenol. 1996;166:149.
21. Blick PW, Flowers MW, Marsden AK, et al. Antibiotics in surgical
treatment of acute abscesses. Br Med J. 1980;281:111.
22. Fine BC, Sheckman PR, Bartlett JC. Incision and drainage of
soft-tissue abscesses and bacteremia. Ann Intern Med. 1985;
23. Feder HM Jr, MacLean WC, Moxon R. Scalp abscess secondary
to fetal scalp electrode. J Pediatr. 1976;89:808.
24. Rudoy RC, Nelson JD. Breast abscess during the neonatal period.
7. If indicated, insert plain, 0.5-inch gauze into abscess
cavity to stop bleeding and/or to serve as a wick to promote drainage (Fig. 48.2B).
8. Apply dry, sterile dressing.
10. Check abscess wound, and apply sterile warm soaks for
20 to 30 minutes, three times a day, until healing has
b. Formation of granulation tissue
c. Resolution of local tissue inflammation
Fig. 48.2. Drainage of a superficial abscess. A: Breaking the
septa with a clamp. B: Packing the wound.
Fig. 48.1. Superficial abscess in the site of a Broviac central
venous line insertion in the left anterior chest wall.
356 Section IX ■ Miscellaneous Procedures
1. Introduction of infection into sterile abscess or hematoma
3. Injury to blood vessels, nerves, or tendons (deep to
4. Incomplete drainage with recurrent abscess formation
6. Scar formation at drainage site, requiring skin graft (23)
7. Reduction of breast size following incomplete drainage
1. Meislin HW, Lerner SA, Graves MH, et al. Cutaneous abscesses.
Anaerobic and aerobic bacteriology and outpatient management.
3. Macfie J, Harvey J. The treatment of acute superficial abscesses: a
prospective clinical trial. Br J Surg.1977;64:264.
4. Butler KH. Incision and drainage. In: Roberts JR, Hedges JR, eds.
Clinical Procedures in Emergency Medicine. 4th ed. Philadelphia:
5. Albom MJ. Surgical gems. Surgical management of a superficial
cutaneous abscess. J Dermatol Surg. 1976;2:120.
6. Brook I. Microbiology and management of human and animal
bite wound infections. Prim Care.2003;30:25.
7. Folz BJ, Lippert BM, Kuelkens C, et al. Hazards of piercing and
facial body art: a report of three patients and literature review. Ann
8. Duong M, Markwell S, Peter J, et al. Randomized, controlled trial
of antibiotics in the management of community-acquired skin
abscesses in the pediatric patient. Ann Emerg Med. 2010;55:401.
9. Lee MC, Rios AM, Aten MF, et al. Management and outcome of
uncomplicated skin abscesses in a population at risk for
community-acquired methicillin-resistant Staphylococcus aureus
infection. Antimicrob Agents Chemother. 2007;51:4044.
13. Halvorson GD, Halvorson JE, Iserson KV. Abscess incision and
14. Hiss J, Horowitz A, Kahana T. Fatal haemorrhage following male
ritual circumcision. J Clin Forensic Med. 2000;7:32.
16. Kirkpatrick BV, Eitzman DV. Neonatal septicemia after circumcision. Clin Pediatr. 1974;13:767.
17. Woodside JR. Necrotizing fasciitis after neonatal circumcision.
18. Trier WC, Drach GW. Concealed penis—another complication
of circumcision. Am J Dis Child. 1973;125:6.
22. Pearce I. Retention of urine: an unusual complication of the
Plastibell device. Br J Urol Int. 2000;85:560.
23. Mackenzie AR. Meatal ulceration following neonatal circumcision. Obstet Gynecol. 1966;28:221.
24. Yildirim S, Taylan G, Akoz T. Circumcision as an unusual cause
of penile lymphedema. Ann Plast Surg. 2003;50:665.
25. Ly L, Sankaran K. Acute venous stasis and swelling of the lower
abdomen and extremities in an infant after circumcision. Can
26. Van Duyn J, Warr WS. Excessive penile skin loss from circumcision. J Med Assoc Ga. 1962;51:394.
27. Auerbach MR, Scanlon JW. Recurrence of pneumothorax as a
28. Peker E, Cagan E, Dogan M. et al. Methemoglobinemia due to
local anesthesia with prilocaine for circumcision.J Pediatr Child
29. Moran LR, Hossain T, Insoft RM. Neonatal seizures following
lidocaine administration for elective circumcision. J Perinatol.
48 Drainage of Superficial Abscesses
1. A localized collection of pus resulting from bacterial
1. To establish free drainage of contents from a superficial
Surgical incision and drainage is the definitive
treatment for soft tissue abscesses. Antibiotic therapy
alone is ineffective in the setting of localized abscess
2. To identify pathogens and direct antimicrobial therapy
3. To differentiate infectious from noninfectious lesions
1. Carefully identify and avoid
2. Avoid premature incision and drainage of abscesses that
have not yet fully matured (i.e., in the initial stages of
induration and inflammation prior to formation of pus)
b. Possible extension of infectious process
Premature incision may be avoided by the use of
ultrasound with or without diagnostic needle aspiration (19,20).
2. Antiseptic swabs or cup containing antiseptic solution
4. Nonbacteriostatic, isotonic saline without preservative
10. 0.5-inch, fine-mesh, plain gauze
1. Ethyl chloride spray as topical anesthetic. (For larger
lesions, local anesthesia with lidocaine may be used.)
Buried penis is usually the result of inappropriate
circumcision in a chubby baby with a small or concealed penis. Excessive removal of skin should be
treated with application of antiseptic (iodophor) daily
and not with grafting or burying the penis in scrotum.
15. Recurrence of pneumothorax (27)
16. Reaction to epinephrine used to control bleeding
b. Local vasospasm (may lead to necrosis of the glans)
17. Complications due to local anesthetic
a. Methemoglobinemia has been reported following
exposure to prilocaine, procaine, benzocaine, and
b. Hematoma; those reported in neonates have
18. Mechanical problems with Gomco clamp (30)
b. Warping of the plate after multiple use
c. Breakage of arm during tightening
d. Grooves and nicks in bell at junction of bell and plate
1. Gairdner D. The fate of the foreskin—a study of circumcision. Br
3. Farley SJ. Neonatal circumcision: the controversy rages on. Nat
4. Yellen HS. Bloodless circumcision of the newborn. Am J Obstet
5. Dubrisin R, Zaprudsky P. Circumcising neonates with the Mogen
clamp. Contemp OB/Gyn. 1991;36:79.
6. Fette A, Schleef J, Haberlik A, et al. Circumcision in pediatric
surgery using an ultrasound dissection scalpel. Technol Health
7. Gough DCS, Lawton N. Circumcision—which dressing?. Br
8. Garry DJ, Swoboda E, Elimian A, et al. A video study of pain relief
during newborn male circumcision. J Perinatol. 2006;26:106.
9. Kirya C, Werthmann MW Jr. Neonatal circumcision and penile
dorsal nerve block—a painless procedure. J Pediatr. 1978;92:998.
10. Essid A, Hamazaoui M, Sahli S, et al. Glans reimplantation after
circumcision accident. Prog Urol. 2005;15:745.
modern medicine and religious tradition. Pediatrics. 2004;114:e259.
12. Barnes S, Ben Chaim J, Kessler A. Postcircumcision necrosis of
13. Bode CO, Ikhisemojie S, Ademuyiwa AO. Penile Injuries from
proximal migration of the Plastibell circumcision ring. J Pediatr
6. Inflammation/ulceration of meatus (9,23)
7. Circumcision of hypospadias
8. Chordee most commonly is the result of dense ventral
scarring from inflammation; may be due to removal of
excess skin from shaft or secondary to a skin bridge
12. Displacement with lodging of Plastibell around penile
prepuce is compressed into the groove by the circumferential suture. B: Appearance of the completed
352 Section IX ■ Miscellaneous Procedures
Fig. 47.6. Complication of circumcision. A: Glans injury
14. Wound separation/removal of excess skin (Fig. 47.6) (26)
f. Check that prepuce is freed from entire surface of
glans. Complete separation if necessary.
11. Complete circumcision using method of choice.
(1) Check clamp to ensure that all parts are present,
fit well, and are in good working order.
(2) Assemble clamp, ensuring that yolk (arm)
articulates correctly with baseplate.
(3) Draw prepuce backward gently to expose
(4) Break down all residual adhesions, and observe
position of meatus. If meatus is abnormal,
(5) Sponge glans dry with gauze swabs.
(6) Select stud (bell) of adequate size (see C), and
place over glans (Fig. 47.4A).
(a) Approximate edge of dorsal slit. (A sterile
(b) Observe amount of skin remaining under
Proper placement of prepuce over stud
is essential. Pulling too taut may lead to
removal of excessive penile skin. Insufficient
tension may lead to incomplete circumcision.
(8) Place baseplate of clamp over stud (with pin
perpendicular to shaft of penis) so that prepuce
is sandwiched between them (Fig. 47.4B).
(9) Continue to pull upward on stud until entire
prepuce is drawn through baseplate and stud
(10) Hook yoke (arm) of clamp under side arms on
shaft of stud and bolt firmly to baseplate, after
checking position of prepuce between stud
Hemostasis is produced by pressure between
baseplate and rim of stud. If the clamp is
removed before 10 minutes has elapsed, wound
edge hemostasis may be inadequate. If significant bleeding occurs during the procedure,
remove the device and search for bleeding
vessel—avoid blindly placing sutures.
(13) Remove prepuce with scalpel held parallel to
and flush with upper surface of baseplate. Never
use electrocautery; however, use of an ultrasound dissection scalpel has been described as a
safe alternative to electrocautery (6).
(14) Loosen bolt on clamp and remove.
(15) Optional: Dress with loose, noncircumferential sterile gauze impregnated with Vaseline.
Gough and Lawton (7) have shown that the
addition of tincture of benzoin to the dressing
adversely affected wound healing and the
addition of topical antibiotic did not produce
better results than those achieved with ordinary paraffin gauze.
ABSTRACT Doxorubicin (Dox) is a highly potent chemotherapy drug. Despite its efficacy, Dox's clinical application is limited due to it...