ABSTRACT

INTRODUCTION AND OBJECTIVE: Several scoring systems have been developed for risk stratification in patients with acute pulmonary embolism (PE). The Pulmonary Embolism Severity Index (PESI) and its simplified version (sPESI) are among the most used, however the high number of variables hinder its application. Our aim was to derive an easy-to-perform score based on simple parameters obtained at admission to predict 30-day mortality in acute PE patients.

METHODS: Retrospective study in 1115 patients with acute PE from two institutions (derivation cohort n=835, validation cohort n=280). Primary endpoint was all-cause mortality at 30 days. Statistically and clinically relevant variables were selected for multivariable Cox regression analysis. We derived and validated a multivariable risk score model and compared to other established scores.

RESULTS: The primary endpoint occurred in 207 patients (18.6%). Our model included five variables weighted as follows: modified shock index ≥ 1.1 (hazard ratio [HR] 2.57, 1.68-3.92, p<0.001),<0.001),<0.001),<0.001),<0.001)<0.0001)

CONCLUSIONS: The PoPE score (https://tinyurl.com/ybsnka8s) is an easy tool with superior performance to predict early mortality in patients admitted for PE with non-high-risk PE.

PMID:37423312 | DOI:10.1016/j.repc.2023.04.011

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PubMed articles on: Cancer & VTE/PE

Venous and arterial thromboembolism after colorectal cancer in the Netherlands: Incidence, predictors, and prognosis

Thromb Res. 2023 Jul 4;229:90-98. doi: 10.1016/j.thromres.2023.06.028. Online ahead of print.