@Catturrd

MH

01:28

Matt Hosner

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Project Veritas 23.09.2021 01:03:02

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BREAKING PART 2: FDA Official: ‘Blow Darting African Americans Is Where We’re Going...Just Shoot Everyone’

'Nazi Germany Registry' of Unvaccinated Americans: “Think About It Like The Jewish Star”

'Go Door-To-Door & Stab Everyone'

#ExposeFDA

DISTRIBUTE THIS VIDEO BY PROXY ON TWITTER ASAP - CLICK HERE: https://ctt.ec/cbn_7

MH

01:49

Matt Hosner

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The Meitryx 🇺🇸 22.09.2021 05:34:08

Scavino's post tonight on FB emphasized the word "PATRIOT".

These drops happen to be 3-year deltas...

https://www.facebook.com/1440616002820798/posts/2983277735221276/

MH

01:52

Matt Hosner

W

Wendy Rogers 22.09.2021 17:58:26

Ya'll ready for this? We have 987k signatures on our petition to #Decertify the Presidential Election. Just 13k away from 1 million signatures. People laughed at me when I said I want 1 million signatures and you patriots are getting it done. The #AZAudit comes out on Friday. I want to hit 1 million before then. SIGN: https://action.wendyrogers.org/decertify/

MH

01:52

Matt Hosner

X

X22 Report Official 22.09.2021 18:00:05

https://www.breitbart.com/politics/2021/09/22/house-republicans-deliver-three-articles-of-impeachment-against-joe-biden/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+breitbart+%28Breitbart+News%29

MH

01:53

Matt Hosner

K

KanekoaTheGreat 22.09.2021 19:08:11

New Proof Emerges About the Hunter Biden Laptop: a Definitive Account of the CIA/Media Fraud

New evidence on Monday proved what has long been clear: that documents about Joe Biden from the Hunter Biden laptop were authentic. Big Tech censorship in the weeks before the 2020 election of these genuine documents is one of the most severe assaults on free speech and a free election in years. That the corporate media was their key ally by endorsing and spreading a CIA lie -- that these documents were "Russian disinformation" -- makes this episode even more grave.

https://rumble.com/vmteq5-new-proof-emerges-about-the-hunter-biden-laptop-a-definitive-account-of-the.html

@KanekoaTheGreat

MH

01:53

Matt Hosner

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Praying Medic 22.09.2021 22:24:38

A DC Judge has denied prosecutor's request to keep videos private in j6 trial.

https://www.buzzfeednews.com/article/zoetillman/capitol-footage-lawsuit-release-insurrection

MH

01:54

Matt Hosner

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MistyG 22.09.2021 21:06:30

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Sidney Powell will get a 2 hour deposition September 23rd, in Colorado where Coomer filed the case.

In Colorado you have a right by statute to say anything of National importance without being slapped with a defamation lawsuit. That could get spicy.

Discovery for the Dominion lawsuit will be filed after the 24th.

“That will be where the rubber meets the road and we are salivating over it”

MH

01:54

Matt Hosner

A

Arizona Informer Channel 22.09.2021 22:43:44

FOR IMMEDIATE RELEASE: Presentation of the Maricopa County Election Audit

WHAT: Members of the Maricopa County election audit team will present their findings to the Senate President and Chair of the Senate Judiciary Committee. This a presentation only and will not include public comment or

questions.

WHO:

Senate President Karen Fann

Judiciary Chair Senator Warren Petersen

Doug Logan, Cyber Ninjas CEO

Ben Cotton, CyFIR Founder

Ken Bennett, Senate Audit Liaison

Randy Pullen, Senate Audit Spokesperson

Dr. Shiva Ayyadurai

WHEN: Friday, September 24, 1 p.m. Arizona time, 4 p.m. EDT

WHERE: State Senate Chambers

Live streamed at:

https://www.azleg.gov/videoplayer/?clientID=6361162879&eventID=2021091005

~~~

Via AZ Senate GOP

MH

02:07

Matt Hosner

02:12

MH

02:15

Matt Hosner

S

Silence DoGood, MBA 22.09.2021 05:01:41

Mike Maloney discovers half a trillion dollars missing, right in the government's very own statistics!

He is not suicidal in case someone within government does not want this coming to fruition.

Well, the cats out of the bag on this one 😲. He even discusses how the pundits will be trained to counteract the numbers and sugar coat it, and his rebuttal to what they will say! Brilliant!

https://youtu.be/KY4kvowEKqA

☕✝️

MH

02:16

Matt Hosner

P

Plastic Girl Reporting™️©️ 22.09.2021 14:30:25

Psalms 34:19

https://t.me/plasticgirlreport

JH

02:18

Jason Hundley

MH

02:19

Matt Hosner

https://www.instagram.com/p/CUGsOPBFCQ2/?utm_medium=share_sheet

02:21

https://www.instagram.com/reel/CUFtbUIAqX4/?utm_medium=share_sheet

MH

02:22

Matt Hosner

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Plastic Girl Reporting™️©️ 22.09.2021 14:36:47

🚨🚨 TOP STORIES 🚨🚨

Good Morning Patriots Happy Wednesday Plastic Girl Reporting here today's top story includes this morning I would like to take a different approach on the news and give you a verse in The Bible. God has a plan for your life. "No one can receive anything unless God gives it from heaven. (John 3:27) God created you and has good plans for your life. To know those plans, you must know God personally.

📈 Biden's average disapproval rate among all the major polls hit 56% for the first time

🆚 51% of Americans favor Trump's performance in office vs. 49% for Biden

🤡 MSNBC host Joy Reid: Gabby Petito coverage is "missing white woman syndrome"

🇨🇳CCP agent Dr. Leana Wen, tells CNN she can’t understand why the FDA failed to follow orders by voting 16-3 AGAINST approving the boosters. She is no doubt sending her people to ‘change their minds’

🗓 Reminder: Arizona's audit of the 2020 election results drop on Friday

👾 Leaked grant proposals from the Wuhan lab show that 18 months before the first Covid-19 cases appeared, researchers submitted plans to release skin-penetrating nanoparticles containing coronaviruses with spike proteins into bat caves in China. The same proposals also described plans to create viruses genetically enhanced to infect humans more easily. [The Telegraph]

🚨 Lawyers for a woman who claims she was forced to have sex with Prince Andrew when she was underage have reportedly served the Duke of York with a sexual assault lawsuit. [The Hill]

🚨 The FBI confirmed Tuesday the body found Sunday in Wyoming is in fact that of missing Youtuber Gabby Petito, and her death appears to have been a homicide. [Forbes] 

✈️ Haitians deported from the U.S. on Tuesday assaulted the pilots onboard one of the flights when it arrived in Port-au-Prince and injured three U.S. immigration officers. [NBC News]

🗳 A dark money group funded by a Swiss billionaire foreign national is spending heavily to lobby moderate Democrats to support "voting rights" legislation that Republicans have railed against as another election power grab by Democrats. [Fox Business]

🗳Maricopa County Supervisor Steve Chucri has announced his resignation from office effective November 5. Yesterday, Steve Chucri said the Maricopa County-led post-election audit was “bullsh*t”.[Gateway Pundit]

🎥Father stands up to sing the National Anthem when they didn't play it.

https://www.instagram.com/reel/CUFtbUIAqX4/?utm_medium=share_sheet

🎥Jon Matos calls out Joe Biden... it is EPIC. [WARNING LANGUAGE]

https://www.instagram.com/p/CUGsOPBFCQ2/?utm_medium=share_sheet

🎥 A Republican candidate for Lt. Governor in Nevada was assaulted by police and dragged out of a city meeting.

https://rumble.com/vmsu6r-nv-lt.-governor-mack-miller-assaulted-by-police-and-dragged-from-clark-coun.html

🎥 Jen Psaki couldn't believe it when a liberal NBC news anchor ROASTED Joe Biden for his failures.

https://rumble.com/vmsvrx-cbs-gayle-king-roasts-psaki-on-bidens-failures.html

📰 Scientists believe they've found evidence of one of the most infamous biblical stories...

https://dailycaller.com/2021/09/21/scientists-evidence-infamous-biblical-stories/

MH

02:23

Matt Hosner

In reply to this message

Truth teller!

02:24

Go find her! 😉

MH

02:24

Matt Hosner

N

Nancy Drew 23.09.2021 02:20:36

https://www.facebook.com/profile.php?id=100073219383090

Follow this one....😘😘💕💕💕💕

02:24

N

Nancy Drew 23.09.2021 02:20:37

MH

02:25

Matt Hosner

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Disclose.tv 22.09.2021 13:42:59

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NEW - Bill Gates on his various venues with pedophile sex offender Epstein: "Well, he’s dead." Case closed.

@disclosetv

MH

02:26

Matt Hosner

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Dan Scavino 🇺🇸 22.09.2021 16:34:04

The “supply line” narrative is coming as well, we’ve been trying to remind everyone September was National Preparedness Month. The DS isn’t finished yet.

@Qtah_17

https://www.bbc.com/news/business-58643717.amp

MH

02:33

Matt Hosner

A

Andy Ngo (Official) 23.09.2021 01:33:26

Keith Leroy Moreno, of Reno, Nev., pled guilty to destroying part of a federal courthouse in Reno during #BLM rioting in May 2020. He was sentenced this month to only probation. https://www.justice.gov/usao-nv/pr/reno-man-pleads-guilty-damaging-federal-courthouse-during-may-2020-protest-reno

02:33

A

 

-Fauci was wrong about #COVID19.

-Mayorkas was wrong about the border.

-Biden’s been wrong about everything.

@JimJordanOhio

MH

14:29

Matt Hosner

W

Wendy Rogers 22.09.2021 13:25:35

Brian Kemp certified a false election and he must go. If he is allowed to stay you will get the same results. Period.

MH

14:29

Matt Hosner

W

Wendy Rogers 22.09.2021 13:26:40

After we take out Brian Kemp he needs to be investigated and arrested.

MH

14:29

Matt Hosner

W

Wendy Rogers 22.09.2021 14:06:44

Dear Aussies, there are more of you than there are of them. Take your country back. We support you. #Freedom 🇦🇺🇦🇺🇦🇺

AC

14:50

Alicia Conde

💪🙏

A

15:49

Amanda

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Connecting Dots 22.09.2021 15:44:15

BREAKING – 🇺🇦 Ukraine: The car of Ukrainian president Zelensky's 1st assistant was the target of gunfire near Kiev. More than 10 machine gun bullets were reportedly fired at the car. The driver is injured. Zelensky's assistant Sergei Shefir was not injured and is safe. https://t.me/ConnectingDotsChannel

15:49

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Connecting Dots 22.09.2021 15:44:15

15:49

C

Connecting Dots 22.09.2021 15:44:15

15:49

C

Connecting Dots 22.09.2021 15:44:15

AC

16:59

Alicia Conde

X

X22 Report Official 22.09.2021 15:24:18

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Protect the farmers, this is all part of the GREAT RESET

AF

17:05

Andrew Fields

In reply to this message

Yes that’s owed but will not go to the people that deserve it

MH

17:58

Matt Hosner

?

🇺🇸👊🏻Richard Citizen Journalist 👊🏻🇺🇸 22.09.2021 11:06:38

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I was walking through a parking lot and kindly asked this guy if he thought masks work. He aggressed right up to my face, like a maniac, started screaming in my face. I caught the tail end on video after he calmed down.

These people are real. I frankly and sadly think there is little to no hope for them. They are programmed brainwashed zombies.

MH

17:59

Matt Hosner

?

🇺🇸👊🏻Richard Citizen Journalist 👊🏻🇺🇸 22.09.2021 12:35:04

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17:59

?

🇺🇸👊🏻Richard Citizen Journalist 👊🏻🇺🇸 22.09.2021 12:35:04

Empty morgue trailers at hospital in Tulsa Oklahoma. Here the proof 👆🏻

Here’s the fake news article 👇🏻

https://www.fox23.com/news/local/hillcrest-hospital-expanding-morgue-with-temporary-trailers/NALKF27SOVE2NAW6KPHYOCFZVY/?outputType=amp

18:08

Deleted Account

Shift is El morte dante‼️❓

18:09

Deleted Account

TT

Thomas T 22.09.2021 15:32:44

18:11

Deleted Account

This is a big expandible lie. Nothing burgers‼️🍔 People have had "enough of this expandible bull shit", I would never support democrats ever again. Lying sacks of shit.

AC

19:37

Alicia Conde

W

Wendy Rogers 22.09.2021 18:59:23

https://www.thegatewaypundit.com/2021/09/breaking-leaked-audio-maricopa-county-supervisor-steve-chucri-admits-dont-feel-comfortable-dominion-county-recorder-stephen-richer-agrees/

⛈

20:02

⛈TheUntamedTruth(OFFICIAL)⛈

Thought this was important to share for as many military members as possible.

ATTENTION MILITARY.

From Attorney Francis Boyle:

“My advice to members of armed forces is that if you are given an order whether orally or in writing to take the Frankenshots, be respectful because they’ll get you for contempt of a superior officer. Don’t lose your cool. And say ‘sir, I respectfully decline to take these Frankenshots. This is an illegal order in violation of the Nuremberg Code on Medical Experimentation that is a Nuremberg Crime under international law, and it is illegal also under the Nuremberg Charter, Judgment and Principles that the United States government was responsible for at Nuremberg and we prosecuted, convicted, and executed Nazis for violating this body of law and so sir, I respectfully decline to take these Frankenshots.’

With all due respect to JAG officers, I’ve worked with them, they’re fine. But JAG officers can only do so much for you, JAG lawyers, they are in the chain of command. You are going to have to go outside & get civilian attorneys who can exercise and assert your rights under the Uniform Code of Military Justice.

Now you have very substantial rights under the Uniform Code of Military Justice and it is a well-known principle of military law that you have no obligation to obey an illegal order.”

Law Building

504 E. Pennsylvania Ave.

Champaign IL 61820 USA

Phone: 217-333-7954

RP

20:04

Rowdy Piper

C

Cherokee Owl 🦉 20.09.2021 13:01:06

Fact 👆🏻

@CherokeeOwl 🦉

Deleted invited Deleted Account

20:19

Deleted Account

R

Reiner Fuellmich 🇺🇸/🇬🇧/🇦🇺 18.09.2021 17:10:00

Dr. Ardis - The insanity of vaccine injuries & deaths

Corona Investigative Committee

Dr Bryan Ardis, US trained doctor and CEO of ArdisLabs.com gave evidence to lawyers of the German Corona Ausschuss Sitting #63. This is an edited english language (part subtitled) extract from the full session.

➥ This way to the short video

➥ This way to the full interview

Lawyer Dr. Reiner Fuellmich, go to channel here:

t.me/ReinerFuellmichEnglish

RP

20:21

Rowdy Piper

ℚ

ℚ𝕦𝕖𝕤𝕥𝕚𝕠𝕟 𝔼𝕧𝕖𝕣𝕪𝕥𝕙𝕚𝕟𝕘 22.09.2021 20:10:32

1 year Delta 💥

20:30

Deleted Account

Q

Qtime Network 🇺🇸🇳🇱 22.09.2021 19:42:24

They Lied Again ! FDA Did Not Approved

https://web.archive.org/web/20210921104940/https://principia-scientific.com/major-law-firm-confirms-fda-deceived-america-with-its-approval-of-pfizer-vax/

21:05

Deleted Account

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Nate Max Human Alliance 22.09.2021 11:58:15

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Chris Sky Fucking legend

21:11

Deleted Account

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We The Memes!!! 21.09.2021 21:44:22

@WeTheMemes 🤣😂😆

RP

21:12

Rowdy Piper

D

Digital Nukes 21.09.2021 20:16:29

@DigitalNukes ☢️

RP

21:14

Rowdy Piper

D

Digital Nukes 22.09.2021 00:40:52

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Serial liar and all-around sleaze bag Adam Schiff has sponsored a House bill which attempts to curtail Presidential power. The irony of all this is that the scum-bags perpetrators are the ones trying to pass this legislation. They’re terrified of President Trump because they know he’s on his way back in.

@DigitalNukes ☢️

B

21:17

Bas

I

Islamic Eschatology Channel ☄ 22.09.2021 21:11:03

A worker in Turkey was FIRED for not taking the vax... so he took to his excavator to make a statement... lol

https://twitter.com/ProKlausSchwab/status/1440566036185563139

MH

21:21

Matt Hosner

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John Durham 22.09.2021 20:07:33

I have provided the access link to my channel, that you can share as we prepare to go into darkness once again. As darkness falls, everything will fall into place, as it should be. We will walk into darkness together as it is the only way to light, guided by God himself on this delightful journey back to truth, freedom and justice as One Nation under God.

https://t.me/joinchat/Q6a0iUItQS43ODM0

There will be more massive teasers on this channel, that will blow your mind, so get ready and SHARE this with everyone you know.

In the end, I would like to thank all the patriots. Your help is greatly appreciated. This wouldn't be possible without you. Keep your heads up, because better days are coming.

A

21:33

Amanda

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James O'Keefe 22.09.2021 20:21:19

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USA Today is trying to ‘fact check’ our ‘claims’ in Part 1 in an apparent attempt to get our videos banned everywhere. So I recorded phone call with Daniel Funke and informed him I will sue USA Today if they defame us.

MH

21:36

Matt Hosner

In reply to this message

❤

AC

22:03

Alicia Conde

❤️

MH

22:11

Matt Hosner

P

Praying Medic 22.09.2021 03:41:24

After a recording was leaked where he bashed other Maricopa Supervisors over the audit, Supervisor Steve Chucri (Dist 2) has resigned, effective November 5th.

MH

22:11

Matt Hosner

P

Praying Medic 22.09.2021 04:31:31

Enjoy the show.

🍿

MH

22:13

Matt Hosner

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MistyG 22.09.2021 13:14:13

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Good morning.. 2 more days!!

Eyes on AZ..

SEPT 21-25 [TRACK & follow events]

Running RED.

Q

MH

22:13

Matt Hosner

D

Dan Scavino 🇺🇸 22.09.2021 15:28:14

Hint: if members of the AZ senate are putting out little hints we’re about to make history then we know the audit is going to be very destructive to the DS. Get ready!

https://t.me/TheStormHasArrived17/5481

MH

22:15

Matt Hosner

U

ULTRA Pepe Lives Matter 🐸 22.09.2021 17:34:01

The Great Awakening is happening in real time.

Be encouraged.

The world is waking up.

https://gab.com/MajorPatriot/posts/106975416580768633

22:15

Deleted Account

Q

QAnon+ 🎯 22.09.2021 17:07:26

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Are these Australian cops human?

MH

22:15

Matt Hosner

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MistyG 22.09.2021 18:59:26

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BREAKING – LEAKED AUDIO: Maricopa County Supervisor Steve Chucri Admits: “I DON’T FEEL COMFORTABLE WITH DOMINION” – And County Recorder Stephen Richer AGREES!

https://www.thegatewaypundit.com/2021/09/breaking-leaked-audio-maricopa-county-supervisor-steve-chucri-admits-dont-feel-comfortable-dominion-county-recorder-stephen-richer-agrees/

MH

22:15

Matt Hosner

P

Praying Medic 22.09.2021 18:46:04

Maricopa Supervisor Steve Chucri admitted that the Board of Supervisors didn't know whether Dominion Voting Systems could be trusted and said they should not automatically defend them. He repeatedly suggested their software should not be used in the 2022 midterm elections.

MH

22:15

Matt Hosner

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Techno_Fog 22.09.2021 18:17:59

Today's hearing in the Michael Sussmann case -

Durham's prosecutor mentioned there would be "classified" discovery.

We believe this has to do with the data the conspirators accessed as part of a "sensitive relationship" with the US govt.

L

22:24

Linda

?

💊 ℝ𝕖𝕕.ℙ𝕚𝕝𝕝.ℙ𝕙𝕒𝕣𝕞𝕒𝕔𝕚𝕤𝕥 💊 21.09.2021 23:46:57

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🚨 BREAKING: Nevada Republican Candidate for Lt. Governor Mack Miller Assaulted by Police and Dragged from Clark County Commissioner’s Meeting

https://bit.ly/3hTRMsb

@RedPillPharmacist

L

22:33

Let Freedom Ring

https://www.theepochtimes.com/mkt_breakingnews/remdesivir-reduced-risk-of-hospitalization-when-given-to-covid-19-patients-early-study_4010494.html

22:34

Epoch times has sold out! 👆🏻👆🏻👆🏻we all know that drug has killed many. It causes renal failure . Do NOT trust Epoch times

L

23:02

Let Freedom Ring

https://youtu.be/oqxAJKy0ii4 so many clues that relate to this game going on

AC

23:14

Alicia Conde

In reply to this message

😡😡😡😡🔥

23:18

In reply to this message

Like hunger games,rat race,back in Rome the gladiators, probably more....just with technology control

23:19

😡

L

23:19

Let Freedom Ring

There’s elites, codes, num 17 a lot, even released on the 17th

MH

23:31

Matt Hosner

N

Nancy Drew 22.09.2021 22:41:48

23:42

Deleted Account

In reply to this message

Thank you Matt for forwarding this. Love Nancy Drew channel, I looked forward to her videos and this is outrageous for FB to do, wow!

23 September 2021

00:08

Deleted Account

W

Wide Awake Truth Seekers 22.09.2021 22:08:29

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DID YOU KNOW THAT AN IPHONE TAKES AN INFRARED PICTURE OF YOUR FACE EVERY FEW SECONDS. HOW CRAZY IS THAT.

😳😳😳

Ephesians 5:11

Take no part in the unfruitful works of darkness, but instead expose them.

John 3:20 

For everyone who does wicked things hates the light and does not come to the light, lest his works should be exposed.

✝️✝️✝️

MH

00:19

Matt Hosner

In reply to this message

You're very welcome

MH

00:51

Matt Hosner

AC

00:52

Alicia Conde

In reply to this message

Thanks for the update,I hope you can find a way to keep it going.I now you can💪🥰shame on f🤬book

01:26

Deleted Account

C

Catturd Fan Club 22.09.2021 23:23:16

Imagine that. https://twitter.com/AtlRey/status/1440739818418233346

@Catturrd

MH

01:27

Matt Hosner

T

The Sacred Blue Tent Channel 23.09.2021 01:09:09

01:28

Deleted Account

C

Catturd Fan Club 22.09.2021 15:41:43

😂😂😂 Bam! https://twitter.com/unspoken_me_/status/1440654311915081734

 

Enyzmes

•Nattokinase (enzyme) and Natto is a traditional Japanese food made from soybeans fermented with Bacillus subtilis var. natto. Natto (also rich in vascular protective Vitamin K2) and Nattokinase have a history of being used to prevent blood clots. The idea is here is that the enzyme Nattokinase goes to work dissolving clots. 2000-4000 Fibrinolytic Units per day (2-4 capsules) with or without food.

03:48

Deleted Account

R

RT News 22.09.2021 00:36:41

Taliban Requests to Address UN General Assembly — Names New Envoy

The Taliban’s new foreign minister Amir Khan Muttaqi has asked to speak to world leaders at this week’s UN General Assembly meeting in New York City, a UN spokesman said Tuesday.

The ambassador of the Afghan government ousted last month by the Taliban, Ghulam Isaczai has also requested to speak at the event, with the UN yet to decide who will properly represent the country at the organization.

No government has yet recognized the Taliban as the new rulers of Afghanistan.

Subscribe to RT t.me/rtintl

03:50

Deleted Account

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Midnight Rider Channel 🇺🇸 22.09.2021 01:30:51

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Bidens climate change fix is to send billions of your money to other countries

04:40

Deleted Account

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Awakening Facts 07.09.2021 15:58:24

This video is very graphic and disturbing viewer is advised and watch at your risk.

https://kofilink.com/1/bnYya2hsMDAxdWpx?dn=1

L

05:03

Let Freedom Ring

Can’t access it and damn sure not downloading it

MH

05:11

Matt Hosner

T

TruthHammer 🙏🇺🇸 (any DM's you get are fake) 22.09.2021 04:58:39

“I’m hurting you to help you. You made me do it.”

-Every Abuser Ever

https://t.me/CodeMonkeyZ/1756

05:15

Deleted Account

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Church of Internal Combustion 18.09.2021 23:40:05

MH

05:20

Matt Hosner

05:21

05:23

MH

05:23

Matt Hosner

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Midnight Rider Channel 🇺🇸 22.09.2021 03:47:06

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Why does Fauci want the kids so bad

SF

05:45

Shelta Frazier

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Trump's Voice NOT 21.09.2021 18:13:54

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The end of the game is approaching

WATCH, LISTEN AND SHARE 🇺🇸

Join:@TrumpsVoice

05:51

Deleted Account

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Sojourners/Patriots 🇺🇸🇺🇸🇺🇸 20.09.2021 02:50:00

My sister in law sent this to my wife via text. She receive it from her friend. If this is true this will rock the whole vaccine narrative.

This was the text just removed her name for privacy and nothing altered:

>>>>>>>>>>>>>>>>>>>>>

Patriot1, [Sep 19, 2021 at 2:56 PM]

A friend of mine, her sister works at Moderna in their vaccination production center. She says that they are all paid huge amounts of money to keep their mouth shut about whats in the vaccine and what its meant to do to the vaccinated person. She was talking about millions of USD that they each get + having to sign confidentiality agreemnts and more legal agreements. So, nobody will ever talk about it all. In short: Once you take the jab and in a matter of minutes, a "plastic-like", sinthetic, microscopic structure is spreading throughout the body and it invades the capilaries. It attaches itself to the most fragile, weakened internal organs you got. There, it RADIATES the organ and the whole body, 24/24. Until it gets significantly damaged. As a result, some people with heart issues will get miocarditis or a heart attack, others with benign ovarian issues will get ovarian cancer, or lungs, kidney, prostate malign issuess. She said to us that the introduction of this structure is DELIBERATE. No design error, no accident, but it is done with the exact purpose of radiating you, similar to plutonium but slower/ impossible to detect. This explains why Geiger EMF devices pick up higher levels of radiation in vaxxed people compared to those not vaccinated. This also explains why being around vaxxed people or having intimate contact with them does influence you at EM field level and you get sick, you bleed or have migrenes and have "radiation-like" symptoms which we call "shedding". Pretty much the PERFECT bio weapon. The same applies to ALL other MRNA vaccines, she said. PLEASE SHARE.

>>>>>>>>>>>>>>>>>>>>

Diane Branstein invited Diane Branstein

DB

06:09

Diane Branstein

https://resistthemainstream.org/watch-man-notices-something-strange-on-mcallen-texas-airport-amid-new-surge/

MH

06:16

Matt Hosner

Your thoughts? You think he's making a good choice??

MH

06:16

Matt Hosner

ℚ

ℚ𝕦𝕖𝕤𝕥𝕚𝕠𝕟 𝔼𝕧𝕖𝕣𝕪𝕥𝕙𝕚𝕟𝕘 21.09.2021 10:10:44

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A Victoria police officer from the riot squad today in Melbourne expressed his own grievances on camera, and revealed that he's being forced to choose between dishonorable police work and bankruptcy.

"I'm just as over this lockdown as you are mate, but this is my job. Im not skilled to do anything else, my wife's out of a job so unfortunately at this time in my life this is what I've gotta do."

MH

06:16

Matt Hosner

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Marjorie Taylor Greene 22.09.2021 03:21:35

Inside this building tonight, Nancy Pelosi is defunding our ally Israel’s Iron Dome so that Ilhan Omar, AOC, & Rashida Tlaib can cheer on Hammas bombing Israel and brag to their radical Islamic donors proving they really are the Jihad Squad.

MH

06:18

Matt Hosner

Wow! What a sad story of a blind sheep... poor poor kid 😔 never stood a chance 😥

MH

06:18

Matt Hosner

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Wakingup1984 13.09.2021 18:40:37

Another weak parent who failed to protect their child and chose to follow the herd. And rather than admit that to herself and others, she chose to double down telling others to do the same.

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06:18

Patty212

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Health Freedom Pennsylvania Public Channel 22.09.2021 00:39:44

If you have been following the damage the covid jab has been doing, this makes sense.

MH

06:18

Matt Hosner

Deleted Account 22.09.2021 06:11:31

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06:39

Patty212

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Usa Awakening 21.09.2021 23:15:02

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Listen to this!!!

Share if you agree with everything Donald Trump said!

Follow @UsaAwakening to be up to date

07:31

Deleted Account

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Wikileaks 21.09.2021 15:07:49

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Propaganda will never die out. Intelligent men must realize that propaganda is the modern instrument by which they can fight for productive ends and help to bring order out of chaos.

-Edward Bernays

Lady Jane invited Lady Jane

07:41

Deleted Account

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We The Memes!!! 16.09.2021 17:18:22

@WeTheMemes 🤣😂😆

Ramona invited Ramona

07:51

Deleted Account

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God 22.09.2021 01:31:11

08:56

Deleted Account

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MARKmobil via @like 22.09.2021 08:33:09

China lieber nicht

Das Verteidigungsministerium von Litauen hat seinen Bürgern den Verzicht auf chinesische Mobiltelefone wie XIAOMI oder HUAWEI empfohlen. Bereits vorhandene Geräte sollten entsorgt werden. Sie enthalten Spionage- und Zensurvorrichtungen.

L

09:54

Liz727

T

Take The Oath 21.09.2021 01:58:02

The Bottomless Pit

@TakeTheOath 🦅

Gerald Stoddard invited Gerald Stoddard

12:19

Deleted Account

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Lichtarbeiter🥰 22.09.2021 06:42:09

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Der Oberste Gerichtshof der USA hat entschieden, dass geimpfte Menschen weltweit Produkte des Staates und keine Menschen mehr sind. Aufgrund der mRNA-DNA-Manipulation im Todesstoß.

Sobald Sie dIe Impfung genommen haben, sind Sie kein Mensch mehr. Sie werden zu Transmenschen im Besitz der Organisation, die das Genom patentiert.

Die Manipulation der mRNA ist irreversibel. Sobald es in dir ist. Sie sind fertig.

Teilt es damit es gestoppt wird

liebe Seelen.💕

Bedingungslose Liebe

Lichtarbeiter 🥰

12:52

Deleted Account

https://youtu.be/h5c__RgQeeQ

12:53

Sorry that's taken down it was on my clipboard dont even know what it was 😂 xx hope your all OK love and light xx

B

12:57

Bas

12:59

MH

14:28

Matt Hosner

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Jim Jordan 22.09.2021 13:54:30

 

03:37

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 14:29:57

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I just caught the end of President Trump on Glen Beck talking about Milley- “bad things should happen to him”

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03:38

Patty212

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Patriot Streetfighter 20.09.2021 17:08:49

03:38

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 14:09:14

https://www.dailymail.co.uk/sciencetech/article-10008567/Google-sends-broadband-Congo-River-beams-light.html

03:40

Deleted Account

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THOUGHTS 19.09.2021 22:58:16

THOUGHTS

https://t.me/myheartbelongstohim

MH

03:42

Matt Hosner

In reply to this message

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03:42

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Midnight Rider Channel 🇺🇸 22.09.2021 03:00:55

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What!

03:45

Deleted Account

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David Avocado Wolfe 02.08.2021 21:16:01

Summary of the Spike Protein and Graphene Oxide Detoxification Protocol

http://bit.ly/SpikeProtein

This is the updated Nutrition protocol to protect those who’ve been injected with spike protein, graphene oxide and mRNA and the same protocol is useful to protect those concerned with the spike protein and graphene oxide shedding coming off those who’ve been injected. We now have evidence of the latest injections containing: mRNA, spike protein, graphene oxide, SM-102, and numerous other potentially toxic substances (also: some—but not all—injections, appear to be higher in graphene oxide and some appear to be saline placebos).

If you know someone who has been injected and requires help, please provide them with this Nutrition Protocol:

Most Important Elements of the Protocol (Shortlist Summary)

Spike Protein: Shikimate neutralizes the S.pike Protein

Shikimate Main Sources to Detox S.pike Protein

• Pine Needle Tea for shikimic acid or shikimate (from green edible pine needles) There are toxic pine needles, be careful! When drinking pine needle tea, drink the oil/resin that accumulates too!

And/Or

• Fennel and/or Star Anise Tea

And/Or

• Schizandra Berry Tea

• Iodine* (dosage depends on brand, more is not better). Iodine is a product you have to start with small dosages and build up over time.

• Vitamin D3* (10,000 IU’s per day)

Graph.ene Oxide Detox:

• C60 (1-3 droppersfull per day): One of the issues we are seeing with those who have been injected is disturbances in their energetic field (magnetism) and hot spots of inflammation. C60 is a rich-source of electrons and acts like a fire extinguisher to inflammation and simultaneously (because it bio-distributes throughout the body) drives a normalization of electron flow throughout the body. In this category, we offer two products, the traditional C60 product* is made by yours truly and the C60 SuperConcentrate* is made by a carbon scientist friend of mine and contains a higher concentration of electrons. C60 is recommended to neutralize s.pike protein, detoxify graphene oxide and SM-102.

• Kohlbitr Activated Charcoal: Take between 400-2000mg (1-5 capsules) a day with water.

• NAC: N-Acetyl Cystiene is the best precursor to glutathione in the body which has the best research for neutralizing graphene oxide. Take 900-1800 mg a day. Get it while you can. The US Federal communist government is trying to make NAC illegal unless you have a doctor’s prescription.

• Enzymes (especially those containing serrapeptase and nattokinase such as VeganZyme— dosage for VeganZymes is 3 caps, twice daily):

Serrapeptase: Serrapeptase provides the anti-inflammatory breakdown of excess and unusual protein. Dosage: 100-200 mg on an empty stomach per day.

Nattokinase: Nattokinase has a long history of being used to prevent blood clots. 2000-4000 Fibrinolytic Units per day (2-4 capsules) with or without food.

Special Note: Iver.mectin is showing great promise against hydrogels containing graphene oxide and found on PCR test swabs, but it is a pharmaceutical, so I do not include it.

Here is the Complete Protocol

•Coated Silver (1-6 drops per day, depending on degree of exposure) (Coated silver blocks the sulfur-bearing protein on the spikes from entering the cell. Sulfur-rich amino acids on the spike protein interact with silver causing them to fold incorrectly).

• NAC (N-acetyl cysteine) (accelerates detoxification and is considered a producer of the super detoxifier glutathione in the body) Dosage: 1200-2400 mg per day on an empty stomach. NAC is recommended to detoxify graphene oxide and SM-102. NAC is tough to find after the FDA recently made it illegal to purchase over the counter in the USA. Request NAC from your doctor!

• Zinc (30-80mg per day depending on immunological pressure)

• Vitamin D3* (10,000 IU’s per day)

• Lyposomal Vitamin C (30ml, twice daily)*

• Quercetin (500-1000 mg, twice daily)*

• Iodine* (dosage depends on brand, more is not better). Iodine is a product you have to start with small dosages and build up over time.

• PQQ* (20-40 mg per day)

P

03:45

Patty212

K

KanekoaTheGreat 21.09.2021 17:22:16

Sidelined? Hundreds of Navy SEALS told they won't be deployed if they refuse COVID vaccine

Several hundred elite Navy SEALs are in danger of being blocked from deploying with their special operator teams by the Pentagon after failing to get a mandatory COVID vaccine.

The number involved in the dispute with the Pentagon amounts to as many as a quarter or more of all active duty SEALs, a loss that could impact military readiness since SEAL teams play an outsized role in modern military operations.

"If they continue to with this asinine police you are going to have the complete decimation of the SEAL teams."

The SEALS are not anti-vaccine; in fact they get all sorts of shots. They just believe more safety data needs to be be available to make their own judgment. And some already have immunity from surviving the disease.

Who would have thought that China Joe's policies would wipe out our SEAL teams❓

https://justthenews.com/government/security/hundreds-navy-seals-face-being-blocked-deployment-refusing-covid-vaccine

@KanekoaTheGreat

03:46

Deleted Account

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Midnight Rider Channel 🇺🇸 22.09.2021 01:21:49

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Biden’s Birder is in purpose

03:46

Deleted Account

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Midnight Rider Channel 🇺🇸 22.09.2021 01:21:59

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Steven Miller - If someone doesn’t hold this presidency accountable there won’t be a country

03:46

Deleted Account

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David Avocado Wolfe 02.08.2021 21:16:01

Shikimate Main Sources:

• Pine Needle Tea for shikimic acid or shikimate (from green edible pine needles) There are toxic pine needles, be careful! When drinking pine needle tea, drink the oil/resin that accumulates too! Shikimate, shikimic acid and their derivatives possess: cancer fighting, antiviral, antimicrobial, anticoagulant and antithrombotic properties.

• Fennel and/or Star Anise Tea: These are also an excellent source of shikimate or shikimic acid (which is known to neutralize the spike protein)

• Schizandra Tea: Ranked in the top three of all superherbs on Earth. Schizandra berries are rich in shikimate amongst numerous extraordinary other properties.

• C60 (1-3 droppersfull per day): One of the issues we are seeing with those who have been injected is disturbances in their energetic field (magnetism) and hot spots of inflammation. C60 is a rich-source of electrons and acts like a fire extinguisher to inflammation and simultaneously (because it bio-distributes throughout the body) drives a normalization of electron flow throughout the body. In this category, we offer two products, the traditional C60 product* is made by yours truly and the C60 SuperConcentrate* is made by a carbon scientist friend of mine and contains a higher concentration of electrons. C60 is recommended to neutralize s.pike protein, detoxify graphene oxide and SM-102.

• Charcoal (2-4 capsules a day): Charcoal is the pre-eminent detoxifier and when taken on an empty stomach, works its way down into the intestines and activates a blood purification process known as “interstitial dialysis”. Our Kohlbitr* product is the premier activated coconut charcoal in the world and we also now offer the more gentle birch charcoal.*

Hesperidin sources to help disable s.pike protein:

• Citrus fruit (especially blood oranges, due to their high hesperidin content — hesperidin is a chalcone like quercetin that deactivates spike protein)

• Peppermint (very high in hesperidin)

Superherbs to help disable s.pike protein:

• Triphala formulations: In Sanskrit, the word Triphala means "three fruits”: a combination of Indian gooseberry (Emblica officinalis), black myrobalan (Terminalia chebula) and belleric myrobalan (Terminalia belerica). The terminalia fruits are rich in shikimate.

• St. John’s Wort (shikimate is found throughout the entire plant and in the flowers)

• Comfrey Leaf (rich in shikimate)

• Feverfew (leaves and flowers are rich in shikimate)

• Gingko Biloba Leaf (rich in shikimate)

• GiantHyssop or Horsemint (Agastache urtifolia) (rich in shikimate)

• LiquidAmbar (Sweet Gum tree) A tea of the spiky seed pods is rich in shikimate.

•Glycyrrhiza glabra (Chinese medicine’s licorice root): Glycyrrhizic acid is extracted from the root of the licorice plant inhibits spike protein. https://pubmed.ncbi.nlm.nih.gov/33041173/

Foods

• Carrots and Carrot Juice (rich in Shikimate)

• Dandelion Leaf (Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro)

Plant Sprouts

• Wheatgrass and Wheatgrass Juice (the young blades are high in shikimate)

• Legume family beans that are generally considered to be rich in shikimate. I have found testing of 5 sprouts and all were rich in shikimate: red kidney bean (Phaseolus vulgaris), moth bean (Vigna aconitifolia), soy bean (Glycine max), mung bean (Vigna radiata) and alfalfa (Medicago saliva). All these were analysed for their shikimic acid content during germination: so the sprouting process is key to activate shikimate production.

 

https://instagram.com/mikepompeo86

Unofficial

https://t.me/MichaelRPompeo

03:23

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 19:39:19

https://www.dailymail.co.uk/health/article-10013497/Scientists-working-develop-plants-deliver-mRNA-vaccine-technology.html

MH

03:23

Matt Hosner

Mike Lindell

Inventor and CEO of MyPillow, Author of "What Are the Odds? From Crack Addict to CEO,” Executive Producer, Creator of MyStore and Lindell Recovery Network

https://t.me/MichaelJLindell

MH

03:24

Matt Hosner

ℚ

ℚ𝕦𝕖𝕤𝕥𝕚𝕠𝕟 𝔼𝕧𝕖𝕣𝕪𝕥𝕙𝕚𝕟𝕘 21.09.2021 23:21:25

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School in Chester, England is served liability papers for their role in facilitating child experimental vaccinations.

This process needs to happen in every school that is allowinr experimentation on their pupils.

MH

03:24

Matt Hosner

🐸 We The Pepe 🐸

🐸 We bake🐸

🐸WWG1WGA🐸

https://t.me/qanonofficial

MH

03:26

Matt Hosner

R

Right Side Broadcasting Network (RSBN) 21.09.2021 01:20:35

Statement by Donald J. Trump, 45th President of the United States of America

MH

03:27

Matt Hosner

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John Durham 20.09.2021 19:32:42

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I'm here.

Join @Real_JohnDurham

MH

03:27

Matt Hosner

John Durham

Special Counsel for the United States Department of Justice

https://t.me/Real_JohnDurham

Deleted invited Deleted Account

03:29

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 17:50:13

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03:31

Matt Hosner

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The Storm 22.09.2021 03:26:58

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18:44, 99.6 MB

RFK JR speaks truth #FightBack

Follow @FreeSpeechParty 🇺🇸🦅

Our store: FreeSpeechParty.store 👕

MH

03:31

Matt Hosner

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World Awakening 22.09.2021 02:20:10

​​A court hearing was held this morning in Georgia regarding the verification of absentee ballots of Fulton County.

Judge Brian Amero gave the State Election Commission and the GBI (Georgia Bureau of Investigation) 20 days to explain to the court what was done to investigate the appearance of fake ballots in Fulton County, Georgia, after defense attorneys said that an investigation of fake ballots was already underway.

Judge Amero then ended the hearing. They will meet again in 20 days.

On Monday evening, VoterGA co-founder Garland Favorito issued a statement about today's hearing.

VoterGA believes that today's hearing confirmed their previous conclusions.

"Today, the court confirmed several things that we have been saying all the time:

There is evidence of election fraud in the affidavits of senior poll managers who swear that they processed fake ballots during a manual counting check in Fulton County.

The applicants ' claims for equal protection and due process of law are well-founded allegations of violations of constitutional rights based on evidence.

It is necessary to check the ballots to determine whether they are fake and whether the constitutional rights of the petitioners have been violated.

@WorldawakeningTrueNews

MH

03:32

Matt Hosner

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Wakey wakey 21.09.2021 20:32:54

Here is the set up for perpetual boosters for years to come......

Pfizer and Moderna say COVID-19 vaccine protection wanes after six to eight months

↙️⬇️↘️

https://nationalpost.com/health/pfizer-and-moderna-say-covid-19-vaccine-protection-wanes-after-six-to-eight-months/wcm/6511eadb-7871-443f-9b8f-0d427e301715/

However they are not talking about the fact that natural immunity is best. With waning vaccine immunity, natural immunity is king.

Why are governments forcing recovered individuals to take the vaccine?

The Pfizer COVID vaccine "protects" against severe disease and death for at least 6 months, while protection against asymptomatic and symptomatic infections wanes rapidly.

They believe that now. COVID is seasonal and endemic. It will ramp up in the northeast in the coming months, regardless of vaccinations.

As soon as the weather gets colder and people with low vitamin D go inside, it’s gonna get really bad up here in the north.

03:32

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Wakey wakey 21.09.2021 20:32:54

03:32

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Wakey wakey 21.09.2021 20:32:54

03:32

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Wakey wakey 21.09.2021 20:32:54

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Wakey wakey 21.09.2021 20:32:55

03:32

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Wakey wakey 21.09.2021 20:32:55

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03:33

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 16:44:05

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MH

03:34

Matt Hosner

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GhostEzra 21.09.2021 21:54:51

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Arrest of a doctor prescribing ivermectin.

03:35

Deleted Account

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Digital Nukes 22.09.2021 01:46:04

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@DigitalNukes ☢️

03:35

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 16:02:13

 WW3 Digital Soldiers 🌍

Previous messages

22 September 2021

MH

03:17

Matt Hosner

The Meitryx

It's me, Lisa Mei Crowley. I will post & share newsworthy items I come across on this channel. It's basically going to be a news feed. I'm intentionally keeping comments turned off to prevent bad actors from posting porn or calls for violence on my feed.

https://t.me/themeitryx

03:17

Deleted Account

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Midnight Rider Channel 🇺🇸 21.09.2021 21:55:27

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00:49, 6.3 MB

MH

03:18

Matt Hosner

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Wendy Rogers 22.09.2021 03:16:28

IT ONLY TAKES TIRELESS IRATE MINORITY TO KEEP THE REPUBLIC ALIVE

MH

03:19

Matt Hosner

Plastic Girl Reporting™️

Made In America

God Fearing Patriot

Freedom Fighter

Defender of the Constitution

Join the commentary:

Main https://t.me/plasticgirlreport

Chat https://t.me/plasticgirlreportin

🇺🇸🦅🗽⚖️🔔🪖🛡⚔️🙏🏼✝️🇺🇸

https://t.me/plasticgirlreport

MH

03:19

Matt Hosner

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Red Pill Truth 22.09.2021 03:15:01

https://www.zerohedge.com/political/there-real-risk-government-will-shutdown-end-month

@RedPillPharmacy 💊

MH

03:19

Matt Hosner

Red Pill Pharmacy

Filling your daily dose of Red Pills!

AmericanSwitchProject.com

https://t.me/RedPillPharmacy

MH

03:19

Matt Hosner

G

General Flynn ️ 22.09.2021 03:14:30

https://rumble.com/vmsi2v-general-flynn-fireside-chat-2-why-its-not-okay-to-say-i-was-just-following-.html

MH

03:19

Matt Hosner

@RealGenFlynn

This is the real General Michael T. Flynn TGS page. I mainly post on Clouthub @GenFlynn

https://t.me/RealGenFlynn

MH

03:20

Matt Hosner

R

Ron Watkins [CodeMonkeyZ] 22.09.2021 03:12:40

https://rumble.com/vmsku4-leaked-audio-maricopa-county-supervisor-thinks-ballot-harvesting-and-dead-v.html

MH

03:20

Matt Hosner

CodeMonkeyZ [Ron Watkins]

Ron Watkins [ gab.com/codemonkey ]

https://t.me/CodeMonkeyZ

Julie invited Julie

MH

03:20

Matt Hosner

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Midnight Rider Channel 🇺🇸 22.09.2021 02:10:29

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So the debt ceiling was established in 1917- Herman is calling it a Pond of piranhas in your backyard next to the swing set and it’s ridiculous to still have it - I just can’t get out of my head that President Trump kept bringing up the flu of 1917 instead of saying 1916 coincidence?

MH

03:21

Matt Hosner

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Donald Trump (Official) 21.09.2021 23:15:03

If You Know You Know😉

MH

03:21

Matt Hosner

D

Donald Trump (Official) 22.09.2021 01:56:01

Psalm 20:4

May he grant you your heart's desire and fulfill all your plans!

MH

03:21

Matt Hosner

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Diamond and Silk 22.09.2021 00:16:16

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🛑 BOOOOM 🛑

BANNED VIDEO - VACCINE LIES EXPOSED - CRIMES AGAINST HUMANITY! - THOUGHTS?

SHARE IT! SHARE EVERYWHERE!

Join👇👇👇

@DiamondandSilkOfficial

MH

03:21

Matt Hosner

UntamedTruth (Official)

A dedicated focus on protecting our children and future generations from lies, deception, false narratives, and suppressed/censored information. Expect numerous feeds per day and a wide variety of topics.

https://t.me/UntamedTruth

MH

03:22

Matt Hosner

KV

Kat Van 21.09.2021 06:45:53

MH

03:22

Matt Hosner

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The Trump Era 47 22.09.2021 00:45:06

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General Flynn says that the Democrat Party no longer exists.

It’s now two groups:

A). Conservatives/Patriots

B). Socialists/Communists

I think we all know which side is going to win this fight.

MH

03:23

Matt Hosner

Q17 - The Storm Is Upon Us

It's time to WAKE up !

Q17 - The Storm Is Upon Us

https://t.me/Q17_TheStorm

MH

03:23

Matt Hosner

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Mike Pompeo 22.09.2021 00:13:25

President Biden was right in saying the world sits at a critical moment and that the world needs strong American leadership.

Unfortunately, that leadership was nowhere to be found during President Biden’s address.

https://www.foxnews.com/opinion/un-biden-world-stage-mike-pompeo

👇👇👇

@MichaelRPompeo

MH

03:23

Matt Hosner

Mike Pompeo

Former U.S. Secretary of State, Director of the CIA, Congressman. Christian, husband, father, Army veteran, Kansan and proud American 🇺🇸

 

ABSTRACT

This study aims to summarize the available data and determine if the presence of venous thromboembolism (VTE) immune-related adverse event (irAE) in patients with immune checkpoint inhibitor (ICI) therapy is associated with improved treatment efficacy and clinical outcomes, which in turn was used to help optimize patient selection for anticoagulation therapy and inform rational treatment strategies for overcoming the mechanisms of ICI resistance. PubMed, Embase, Web of Science, and Cochrane Library were searched up to March 18, 2023, for studies assessing the relationship between VTE irAE development during ICI therapy and cancer outcomes. Seven primary articles with a total of 4437 patients were included in the overall survival (OS) meta-analysis. Patients with VTE had a significant increase in overall mortality compared to patients without VTE in adjusted hazard ratios (HRs 1.36, 95% confidence interval [CI] 1.06-1.75, P = .02). In the studies where immortal time bias (ITB) was accounted for, patients with VTE irAE also had poor OS than those without. HR and the corresponding 95% CI values in the non-ITB group were 2.53 (1.75-3.66, P < .00001) with low heterogeneity (P = .17, I2 = 48%) and 1.21 (1.06-1.37, P = .004) in the ITB group with no heterogeneity (P = .95, I2 = 0%), respectively. Despite the heterogeneity identified, the evidence does suggest that VTE irAE occurrence could be served as a prognostic indicator, with higher frequencies of occurrence associated with poorer OS. However, the fundamental role of this association with clinical consequences should be further investigated in large cohorts and clinical trials.

PMID:37844585 | PMC:PMC10586005 | DOI:10.1177/10760296231206799

00:04

PubMed articles on: Cancer & VTE/PE

Pulmonary Embolism Treatment Evolution: A Comparative Analysis of Pulmonary Embolism Response Team Management at a Single Institution

Am J Cardiol. 2023 Oct 14;208:171-172. doi: 10.1016/j.amjcard.2023.09.003. Online ahead of print.

NO ABSTRACT

PMID:37844520 | DOI:10.1016/j.amjcard.2023.09.003

00:04

PubMed articles on: Cancer & VTE/PE

Causal effect of atrial fibrillation on pulmonary embolism: a mendelian randomization study

J Thromb Thrombolysis. 2023 Oct 15. doi: 10.1007/s11239-023-02903-w. Online ahead of print.

ABSTRACT

Atrial fibrillation (AF) can increase thrombosis, especially arterial thrombosis, and some studies show that AF patients have a higher risk of developing pulmonary embolism (PE). The objective of our study is to investigate whether there is a direct causal effect of AF on PE. A two-sample Mendelian randomization (MR) approach was utilized to determine whether there is a causal relationship between AF and PE. European population-based consortia provided statistical data on the associations between Single Nucleotide Polymorphisms (SNPs) and relevant traits. The AF dataset was obtained from genome-wide association studies (GWAS) comprising 60,620 cases and 970,216 controls, while a GWAS of 1846 cases and 461,164 controls identified genetic variations associated with PE. Estimation of the causal effect was mainly performed using the random effects inverse-variance weighted method (IVW). Additionally, other tests such as MR-Egger intercept, MR-PRESSO, Cochran's Q test, "Leave-one-out," and funnel plots were conducted to assess the extent of pleiotropy and heterogeneity. Using 70 SNPs, there was no evidence to suggest an association between genetically predicted AF and risk of PE with multiplicative random-effects IVW MR analysis (odds ratio = 1.0003, 95% confidence interval: 0.9998-1.0008, P = 0.20). A null association was also observed in other methods. MR-Egger regression and MR-PRESSO respectively showed no evidence of directional (intercept, - 2.25; P = 0.94) and horizontal(P-value in the global heterogeneity test = 0.99) pleiotropic effect across the genetic variants. No substantial evidence was found to support the causal role of AF in the development of PE. Causal effect of atrial fibrillation on pulmonary embolism: a Mendelian randomization study. AF atrial fibrillation, PE pulmonary embolism, GWAS genome-wide association studies, SNPs single nucleotide polymorphisms, OR odds ratio, CI confidence interval.

PMID:37839022 | DOI:10.1007/s11239-023-02903-w

00:04

PubMed articles on: Cancer & VTE/PE

Concomitant Cerebral Venous Thrombosis and Intracranial Hemorrhages in Presentation of a Patient with Secondary Polycythemia: A Case Report

Am J Case Rep. 2023 Oct 15;24:e941507. doi: 10.12659/AJCR.941507.

ABSTRACT

BACKGROUND Cerebral ischemia and hemorrhages were reported to be the main complications of polycythemia vera (PV). The relationship between PV and increased risk of the cerebrovascular events has been established. Some patients with secondary polycythemia have thromboembolic events comparable to those of PV. However, secondary polycythemia that leads to cerebrovascular events is uncommon. CASE REPORT A 35-year-old man without any prior medical history presented with mild clinical acute ischemic stroke and polycythemia. The patient then showed worsening neurological deficits that were later attributed to the concurrent cerebral venous thrombosis, which led to malignant cerebral infarction with hemorrhagic transformation, and subarachnoid hemorrhage. His polycythemia appeared to be secondary to bacterial infection. The treatments for the secondary polycythemia were first phlebotomy and intravenous hydration, followed by intravenous broad-spectrum antibiotics. PV was excluded because the JAK2 V617F mutation was absent, the patient's peripheral blood smear suggested secondary polycythemia due to bacterial infection, and there were improvements in hemoglobin, erythrocyte count, and hematocrit after intravenous antibiotics. At the 1-month follow-up, he was moderately dependent, and hemoglobin, erythrocyte count, and hematocrit were within normal limits, without receiving any further phlebotomy or cytoreductive agents. CONCLUSIONS This case highlights the plausible causation of secondary polycythemia that could lead to concomitant cerebral thrombosis and hemorrhagic events. The diagnosis of cerebral venous thrombosis should be considered in a patient who presents with headache, focal neurological deficits, polycythemia, and normal head computed tomography scan.

PMID:37838828 | PMC:PMC10584197 | DOI:10.12659/AJCR.941507

 

ABSTRACT

Non-bacterial thrombotic endocarditis (NBTE) involves the deposition of fibrin and platelets on heart valves, frequently leading to systemic embolism. The association between NBTE and cancer demands thorough investigation in cases lacking an evident cause. This case report elucidates the clinical course of a nonsmoking woman in her sixties with NBTE linked to pulmonary adenocarcinoma. The patient, who had a history of multiple sclerosis (MS) and was receiving dimethyl fumarate treatment, presented to the emergency department with stroke-like symptoms. Diagnostic challenges arose due to preexisting motor sensory impairment from MS. Initial evaluations revealed hypocapnia and elevated inflammatory markers. Blood cultures were obtained twice, and imaging confirmed pneumonia, left pleural effusion, and chronic pulmonary embolism while excluding acute vascular events or intracranial hemorrhage. The first transthoracic echocardiogram (TTE) indicated no cardiac abnormalities. Treatment encompassed parenteral antibiotics, systemic anticoagulation, and admission to medical floors. Although the initial treatment yielded a positive clinical response, subsequent complications emerged. On the tenth day, the patient required additional interventions, including broad-spectrum antibiotics and supplemental oxygen. A follow-up chest X-ray revealed persistent pneumonia and pleural effusion, and blood cultures upon admission returned negative. A subsequent head MRI confirmed an embolic stroke and displayed evidence of MS progression. Around the twentieth day, empirical treatment for infective endocarditis was initiated, and an 8 mm vegetation on the aortic valve was identified via transesophageal echocardiography (TOE). Acute pulmonary edema prompted a transfer to the intermediate care unit. Further investigations, including left thoracocentesis and CT, unveiled exudate and metastatic lesions in the liver, ilium, and kidney. Unfortunately, on the twenty-fifth day, the patient experienced acute myocardial infarction, right leg ischemia, disseminated intravascular coagulation, and shock. Pleural fluid analysis revealed malignant cells suggestive of lung adenocarcinoma. This case underscores the pivotal role of timely NBTE recognition and the search for malignancy when workup for infective endocarditis and autoimmune panels is negative. Moreover, it emphasizes the significance of vigilant monitoring, particularly in immunocompromised individuals or those with preexisting neurological deficits, especially when new neurological symptoms manifest. These insights significantly contribute to the comprehension of NBTE management and its implications for analogous patient cohorts.

PMID:37846253 | PMC:PMC10576842 | DOI:10.7759/cureus.45271

00:04

PubMed articles on: Cancer & VTE/PE

A framework to characterise the reproducibility of meta-analysis results with its application to direct oral anticoagulants in the acute treatment of venous thromboembolism

Res Synth Methods. 2023 Oct 17. doi: 10.1002/jrsm.1676. Online ahead of print.

ABSTRACT

The number of meta-analyses of aggregate data has dramatically increased due to the facility of obtaining data from publications and the development of free, easy-to-use, and specialised statistical software. Even when meta-analyses include the same studies, their results may vary owing to different methodological choices. Assessment of the replication of meta-analysis provides an example of the variation of effect 'naturally' observed between multiple research projects. Reproducibility of results has mostly been reported using graphical descriptive representations. A quantitative analysis of such results would enable (i) breakdown of the total observed variability with quantification of the variability generated by the replication process and (ii) identification of which variables account for this variability, such as methodological quality or the statistical analysis procedures used. These variables might explain systematic mean differences between results and dispersion of the results. To quantitatively characterise the reproducibility of meta-analysis results, a bivariate linear mixed-effects model was developed to simulate both mean results and their corresponding uncertainty. Results were assigned to several replication groups, those assessing the same studies, outcomes, treatment indication and comparisons classified in the same replication group. A nested random effect structure was used to break down the total variability within each replication group and between these groups to enable calculation of an intragroup correlation coefficient and quantification of reproducibility. Determinants of variability were investigated by modelling both mean and variance parameters using covariates. The proposed model was applied to the example of meta-analyses evaluating direct oral anticoagulants in the acute treatment of venous thromboembolism.

PMID:37846195 | DOI:10.1002/jrsm.1676

00:04

PubMed articles on: Cancer & VTE/PE

Associations Between Immune-Related Venous Thromboembolism and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231206799. doi: 10.1177/10760296231206799.

 

ABSTRACT

BACKGROUND: Clinical management of patients with deep vein thrombosis (DVT) is centered around their risk of recurrent venous thromboembolism (VTE) and post-thrombotic syndrome (PTS). While chronic inflammatory disease (CID) has been established as a risk factor of (recurrent) VTE, research about its potential impact on PTS is lacking.

OBJECTIVES: We aimed to assess the risk of PTS in patients with CID, stratifying for the use of anti-inflammatory treatment.

PATIENTS/METHODS: Consecutive patients with proximal DVT and no active cancer between 2003 and 2018 received a two-year prospective follow-up. CID included inflammatory bowel disease, rheumatic diseases, and gout. Residual venous obstruction (RVO) was assessed by compressive ultrasound after 3-6 months. PTS was diagnosed using the Villalta score after 6-24 months. Hazard ratios (HR) and odds ratios (OR) were adjusted for patient characteristics. The medical ethics committee approved this study.

RESULTS: In total 82 of 801 patients had CID (10.2 %). PTS more often developed in patients with CID (35.4% vs. 18.9 %, p < 0.001) than in those without CID (HR 1.72 [1.15-2.58]). The prevalence of RVO was similar in patients with and without CID (36.8% vs. 41.4 %), and RVO was strongly associated with PTS in patients with CID (OR 3.21 [1.14-9.03]). Moreover, patients with untreated CID (44 %, n = 36) more often had RVO than those with treated CID (51.6% vs. 26.7 %, p = 0.027), and accordingly had a higher risk of PTS (HR 2.18 [1.04-4.58]).

CONCLUSIONS: Patients with CID had an increased risk of developing PTS, especially those without anti-inflammatory treatment, possibly due to an unfavorable impact on RVO-related venous pathology.

PMID:37852838 | DOI:10.1016/j.ejim.2023.10.014

00:04

PubMed articles on: Cardio-Oncology

The (pro)renin Receptor - A Regulatory Nodal Point in Disease Networks

Curr Drug Targets. 2023 Oct 25. doi: 10.2174/0113894501250617231016052930. Online ahead of print.

ABSTRACT

Experimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct diseases in which the (P)RR is involved. The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara et al., is the center of this mini-review since it can mechanistically link the protein-protein interaction level with the pathophysiological level. More detailed insights into the 3D structure of the (P)RR and its interaction domains might guide drug discovery on this novel target. Finally, antibody- and small molecule-based approaches to inhibit the (P)RR are shortly discussed.

PMID:37885110 | DOI:10.2174/0113894501250617231016052930

00:04

PubMed articles on: Cancer & VTE/PE

Unveiling Lung Adenocarcinoma: Non-bacterial Thrombotic Endocarditis as the Debut Sign

Cureus. 2023 Sep 14;15(9):e45271. doi: 10.7759/cureus.45271. eCollection 2023 Sep.

 

ABSTRACT

Thrombocytopenia occurs frequently in patients with cancer-associated thrombosis (CAT), however prospective evaluation of clinical outcomes following randomization to anticoagulants is limited. The HOKUSAI VTE Cancer study was a randomized, open-label, non-inferiority, phase III trial comparing dalteparin with edoxaban in CAT patients. This post hoc analysis of Hokusai VTE Cancer Study was performed to compare outcomes in patients with platelet count ≤100 K/μL at one or more specified time points (baseline, 1-month, or 3-month) versus those without thrombocytopenia. Cumulative incidences at 180 days were calculated with death as a competing risk. The primary outcome was major bleeding; secondary outcomes were clinically relevant non-major bleeding (CRNMB), recurrent thrombosis, and survival. The analysis included 1,045 patients with primarily solid tumor malignancies (89%), median age 65 years, and 52% male. The thrombocytopenia group comprised 9.6% (N=101) of the cohort and relative to the non-thrombocytopenia cohort (N=944), experienced significantly higher major bleeding (9.0% vs. 4.0%, sub-distribution hazard ratio (SHR) 2.4, P=0.02) and CRNMB (17.9% vs. 9.6%, SHR 2.0, P=0.01). Thrombocytopenia did not impact recurrent VTE (9.8% vs. 7.4%, SHR 1.3, P=0.37) nor overall mortality (21.8% vs. 26.0%, HR 0.9, P=0.48). Major bleeding was higher in patients with thrombocytopenia and gastrointestinal malignancies receiving edoxaban versus dalteparin (16.8% vs 0, p.

PMID:37855029 | DOI:10.3324/haematol.2023.284192

00:04

PubMed articles on: Cardio-Oncology

Irbesartan ameliorates inflammation via transendothelial leukocyte migration due to VCAM-1/NOX-1 signaling in cisplatin-induced cardiotoxicity

Iran J Basic Med Sci. 2023;26(11):1298-1304. doi: 10.22038/IJBMS.2023.70997.15422.

ABSTRACT

OBJECTIVES: Cisplatin (CP) is frequently used in various types of cancers. The cardiotoxic effects of this agent limit its usage. Our study seeks to investigate the protective effects of Irbesartan (IRB) on CP-induced cardiotoxicity.

MATERIALS AND METHODS: The following four groups comprised thirty-two rats: control, CP, CP+IRB, and IRB. On the fourth day of the experiment, 5 mg/kg of CP was given to CP and CP+IRB groups intraperitoneally, and for seven days, water or IRB 50 mg/kg (orally) was administered. Vascular endothelial growth factor (VEGF), caspase-3 (Cas-3), vascular cell adhesion molecule-1 (VCAM-1), NADPH oxidase-1 (NOX-1), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH) were measured.

RESULTS: The levels of VCAM-1, NOX-1, VEGF, Cas-3, and LDH were increased in the CP group. The treatment with IRB decreased VCAM-1, NOX-1, VEGF, Cas-3, and LDH levels significantly (P0.05). Histopathological examination revealed normal heart architecture in Control and IRB groups. While marked hyperemia and myocardial cell degeneration were noticed in the CP group, significant amelioration was observed in the CP+IRB group. Aortas in the CP group showed endothelial damage and desquamation. IRB treatment markedly ameliorated histopathological findings in the CP+IRB group. Cardiac and aortic damage caused by CP was attenuated by IRB treatment owing to the anti-inflammatory and antiapoptotic effects of IRB.

CONCLUSION: IRB may help reduce the severity of CP-induced cardiac injury by limiting leukocyte migration and reducing inflammation and apoptosis.

PMID:37885998 | PMC:PMC10598814 | DOI:10.22038/IJBMS.2023.70997.15422

00:04

PubMed articles on: Cancer & VTE/PE

Chronic inflammatory diseases increase the risk of post-thrombotic syndrome: A prospective cohort study

Eur J Intern Med. 2023 Oct 16:S0953-6205(23)00369-2. doi: 10.1016/j.ejim.2023.10.014. Online ahead of print.

 

ABSTRACT

Despite current advancements in chemotherapy, immunotherapy and targeted treatments, the potential for major adverse cardiovascular events, regardless of previous cardiac history, persists. Scoring systems, such as the Heart Failure Association-International Cardio-Oncology Society (HFA-ICOS) risk assessment tool, can be utilized to evaluate several factors including prior cardiac history, risk factors and cardiac biomarkers to categorize patients into low, moderate, high, and very high-risk groups. Common cardiotoxicity complications include new or worsening left ventricular ejection fraction (LVEF), QT interval prolongation, myocardial ischaemia, hypertension, thromboembolic disease, cardiac device malfunction and valve disease. Baseline electrocardiogram (ECG) and transthoracic echocardiogram (TTE) are routinely performed for all patients commenced on cardiotoxic treatment, while other imaging modalities and biochemical markers have proven useful for monitoring. Management mainly includes early risk stratification and prompt identification of cardiovascular complications, with patient-specific surveillance throughout treatment. A multidisciplinary approach is crucial in determining the relationship between potential treatment benefits and cardiotoxicity, and whether the continuation of treatment is appropriate on a case-by-case basis. Early risk stratification, optimizing the patient's cardiovascular status prior to treatment, and prompt identification of suspected cardiotoxicity are key in significantly reducing risk. This article provides a comprehensive review of the various types of treatment-related cardiotoxicity, offering guidance on identifying high-risk patients, recognizing early signs of cardiotoxicity, and outlining appropriate treatment approaches and follow-up care for such cases.

PMID:37886969 | PMC:PMC10605822 | DOI:10.3390/cimb45100526

00:04

PubMed articles on: Cancer & VTE/PE

The prevalence of relevant drug-drug interactions and associated clinical outcomes in patients with cancer-associated thrombosis on concurrent anticoagulation and anticancer or supportive care therapies

Thromb Res. 2023 Oct 11;231:128-134. doi: 10.1016/j.thromres.2023.10.004. Online ahead of print.

ABSTRACT

BACKGROUND: A main concern in the management of patients with cancer-associated thrombosis (CAT) is drug-drug interactions (DDIs) between anticoagulants and anticancer therapies. Their clinical implications remain unclear.

METHODS: To quantify the prevalence of DDIs and risks of recurrent venous thromboembolism (VTE) and bleeding events in patients with CAT on anticoagulation, we conducted a retrospective cohort study in patients with CAT on concurrent anticoagulants and anticancer and/or supportive care therapies. All patients were followed for 6 months from CAT diagnosis or until death (whichever occurred first). The primary outcome was the percentage of patients with anticoagulant DDIs classified as risk C, D, or X in Lexicomp® at any time during the 6 months. Secondary outcomes included recurrent VTE and clinically relevant bleeding events. We calculated the 6-month cumulative incidence of outcomes with 95 % confidence interval (CI) and compared those with and without DDIs, considering death as a competing risk.

RESULTS: Among 267 patients included, 111 (41.6 %) had DDIs with anticoagulants at any time during the study. Those on DOACs at any time had more DDIs compared to LMWH (50.9 % vs 19.3 %, p < 0.0001). The 6-month incidence was 8.2 % (95 % CI 5.3-11.9) for recurrent VTE and 6.7 % (95 % CI 4.2-10.2) for clinically relevant bleeding, with no significant differences between groups with or without DDIs.

CONCLUSIONS: There are high incidences of DDIs in patients with CAT on anticoagulants, more with DOACs. DDIs classified as risk C, D, or X by Lexicomp® were not associated with recurrent VTE or bleeding events in our cohort.

PMID:37857226 | DOI:10.1016/j.thromres.2023.10.004

00:04

PubMed articles on: Cardio-Oncology

Retraction: Longitude variation of the microRNA-497/FGF-23 axis during treatment and its linkage with neoadjuvant/adjuvant trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients

Front Surg. 2023 Oct 11;10:1307330. doi: 10.3389/fsurg.2023.1307330. eCollection 2023.

ABSTRACT

[This retracts the article DOI: 10.3389/fsurg.2022.862617.].

PMID:37886634 | PMC:PMC10599136 | DOI:10.3389/fsurg.2023.1307330

00:04

PubMed articles on: Cancer & VTE/PE

Pulmonary Embolism Unplugged: Catheter-Directed Therapies for Intermediate-Risk Pulmonary Embolism

JACC Cardiovasc Interv. 2023 Sep 27:S1936-8798(23)01212-8. doi: 10.1016/j.jcin.2023.08.029. Online ahead of print.

NO ABSTRACT

PMID:37855803 | DOI:10.1016/j.jcin.2023.08.029

00:04

PubMed articles on: Cancer & VTE/PE

Impact of mild thrombocytopenia on bleeding and recurrent thrombosis in cancer

Haematologica. 2023 Oct 19:0. doi: 10.3324/haematol.2023.284192. Online ahead of print.

 

ABSTRACT

Anti HER2 therapy and left breast adjuvant radiation therapy (RT) can both result in cardiotoxicity. The aim of this study was to evaluate the influence of radiation dose on cardiac structures on the values of the early cardiotoxicity marker high-sensitivity cardiac troponin I (hscTnI) in patients with HER2-positive left breast cancer undergoing adjuvant concomitant antiHER2 therapy and radiotherapy, and to establish a correlation between the hscTnI values and cardiac radiation doses. Sixty-one patients underwent left breast hypofractionated radiotherapy in parallel with anti-HER2 therapy: trastuzumab, combined trastuzumab-pertuzumab or trastuzumab emtansine (T-DM1). The hscTnI values were measured prior to and upon completion of radiotherapy. A significant increase in hscTnI was defined as >30% from baseline, with the second value being 4 ng/L or higher. Dose volume histograms (DVH) were generated for the heart, left ventricle (LV) and left anterior descending artery (LAD). The hscTnI levels were corelated with radiation doses on cardiac structures. An increase in hscTnI values was observed in 17 patients (Group 1). These patients had significantly higher mean radiation doses for the heart (p = 0.02), LV (p = 0.03) and LAD (p = 0.04), and AUC for heart and LV (p = 0.01), than patients without hscTnI increase (Group 2). The patients in Group 1 also had larger volumes of heart and LV receiving 2 Gy (p = 0.01 for both) and 4 Gy (p = 0.02 for both). LAD differences were observed in volumes receiving 2 Gy (p = 0.03), 4 Gy (p = 0.02) and 5 Gy (p = 0.02). The increase in hscTnI observed in patients receiving anti-HER2 therapy after adjuvant RT was positively associated with radiation doses on the heart, LV and LAD.

PMID:37887554 | PMC:PMC10605836 | DOI:10.3390/curroncol30100654

00:04

PubMed articles on: Cardio-Oncology

Cardiac Toxicities in Oncology: Elucidating the Dark Box in the Era of Precision Medicine

Curr Issues Mol Biol. 2023 Oct 15;45(10):8337-8358. doi: 10.3390/cimb45100526.

 

ABSTRACT

Cardiotoxicity is a growing concern in the oncology population. Transthoracic echocardiography and multigated acquisition scans have been used for surveillance but are relatively insensitive and resource intensive. Innovative imaging techniques are constrained by cost and availability. More sensitive, cost-effective cardiotoxicity surveillance strategies are needed. Circulating cardiovascular biomarkers could provide a sensitive, low-cost solution. Biomarkers such as troponins, natriuretic peptides (NPs), novel upstream signals of oxidative stress, inflammation, and fibrosis as well as panomic technologies have shown substantial promise, and guidelines recommend baseline measurement of troponins and NPs in all patients receiving potential cardiotoxins. Nonetheless, supporting evidence has been hampered by several limitations. Previous reviews have provided valuable perspectives on biomarkers in cancer populations, but important analytic aspects remain to be examined in depth. This review provides comprehensive assessment of critical challenges and solutions in this field, with focus on analytical issues relating to biomarker measurement and interpretation. Examination of evidence pertaining to common and serious forms of cardiotoxicity reveals that improved study designs incorporating larger, more diverse populations, registry-based approaches, and refinement of current definitions are key. Further efforts to harmonize biomarker methodologies including centralized biobanking and analyses, novel decision limits, and head-to-head comparisons are needed. Multimarker algorithms incorporating machine learning may allow rapid, personalized risk assessment. These improvements will not only augment the predictive value of circulating biomarkers in cardiotoxicity but may elucidate both direct and indirect relationships between cardiovascular disease and cancer, allowing biomarkers a greater role in the development and success of novel anticancer therapies.

PMID:37889193 | DOI:10.1161/JAHA.123.029574

00:04

PubMed articles on: Cancer & VTE/PE

In vivo evaluation of the pharmacokinetic interactions between almonertinib and rivaroxaban, almonertinib and apixaban

Front Pharmacol. 2023 Oct 4;14:1263975. doi: 10.3389/fphar.2023.1263975. eCollection 2023.

ABSTRACT

Background: Almonertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is commonly used as a first-line treatment for non-small cell lung cancer (NSCLC) patients with EGFR T790M mutations. Rivaroxaban and apixaban are a selective, direct factor Xa inhibitor used to treat venous thromboembolism (VTE), which is a frequent complication of NSCLC. Rivaroxaban and apixaban are substrates of CYP3A4, P-gp and BCRP, whereas almonertinib is an inhibitor of P-gp and BCRP. Rivaroxaban or apixaban are often prescribed together with almonertinib in NSCLC patients, but clear information on pharmacokinetic drug interaction is lacking. Therefore, this study aimed to unravel the extent of interactions between almonertinib-rivaroxaban and almonertinib apixaban in rats, and whether the pharmacokinetic interaction can be mitigated by rivaroxaban and apixaban dose adjustment. Methods: Rats were divided into ten groups (n = 6) that received rivaroxaban (2 mg/kg) (group 1), apixaban (0.5 mg/kg) (group 2), almonertinib (15 mg/kg) (group 3, group 4), almonertinib with rivaroxaban (2 mg/kg) (group 5), almonertinib with rivaroxaban (1 mg/kg) (group 6), almonertinib with apixaban (0.5 mg/kg) (group 7), almonertinib with apixaban (0.25 mg/kg) (group 8), rivaroxaban (2 mg/kg) with almonertinib (group 9), apixaban (0.5 mg/kg) with almonertinib (group 10). The concentrations of drugs were determined by an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The levels of messenger RNA were determined using quantitative real-time polymerase chain reaction (qRT-PCR). Results and Discussion: The results indicate that almonertinib increased the Cmax and AUC0-t of 2 mg/kg rivaroxaban by 3.30 and 3.60-fold, 1 mg/kg rivaroxaban by 1.28 and 1.90-fold. Almonertinib increased the Cmax and AUC0-t of 0.5 mg/kg apixaban by 2.69 and 2.87-fold, 0.25 mg/kg apixaban by 2.19 and 2.06-fold. In addition, rivaroxaban also increased systemic exposure to almonertinib. The results of qRT-PCR showed that almonertinib reduced the expression of Cyp3a1 in liver and intestine, and Abcb1a, Abcg2 in intestine and kidney. The pharmacokinetic results suggest that it is important to take special care of the interactions of these drugs in clinical applications.

PMID:37860116 | PMC:PMC10582335 | DOI:10.3389/fphar.2023.1263975

00:04

PubMed articles on: Cardio-Oncology

Correlation of High-Sensitivity Cardiac Troponin I Values and Cardiac Radiation Doses in Patients with Left-Sided Breast Cancer Undergoing Hypofractionated Adjuvant Radiotherapy with Concurrent Anti-HER2 Therapy

Curr Oncol. 2023 Oct 6;30(10):9049-9062. doi: 10.3390/curroncol30100654.

 

ABSTRACT

Cardiovascular disease (CVD) caused by anti-cancer drug-induced cardiotoxicity is now the second leading cause of mortality among cancer survivors. It is necessary to establish efficient in vitro models for early predicting the potential cardiotoxicity of anti-cancer drugs, as well as for screening drugs that would alleviate cardiotoxicity during and post treatment. Human induced pluripotent stem cells (hiPSCs) have opened up new avenues in cardio-oncology. With the breakthrough of tissue engineering technology, a variety of hiPSC-derived cardiac microtissues or organoids have been recently reported, which have shown enormous potential in studying cardiotoxicity. Moreover, using hiPSC-derived heart-on-chip for studying cardiotoxicity has provided novel insights into the underlying mechanisms. Herein, we summarize different types of anti-cancer drug-induced cardiotoxicities and present an extensive overview on the applications of hiPSC-derived cardiac microtissues, cardiac organoids, and heart-on-chips in cardiotoxicity. Finally, we highlight clinical and translational challenges around hiPSC-derived cardiac microtissues/organoids/heart-on chips and their applications in anti-cancer drug-induced cardiotoxicity. • Anti-cancer drug-induced cardiotoxicities represent pressing challenges for cancer treatments, and cardiovascular disease is the second leading cause of mortality among cancer survivors. • Newly reported in vitro models such as hiPSC-derived cardiac microtissues/organoids/chips show enormous potential for studying cardio-oncology. • Emerging evidence supports that hiPSC-derived cardiac organoids and heart-on-chip are promising in vitro platforms for predicting and minimizing anti-cancer drug-induced cardiotoxicity.

PMID:37889357 | DOI:10.1007/s10565-023-09835-4

00:03

PubMed articles on: Cancer & VTE/PE

Clinical Care of Pediatric Patients with or At-Risk of Post-Thrombotic Syndrome: Guidance from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Haemostasis

J Thromb Haemost. 2023 Oct 20:S1538-7836(23)00780-8. doi: 10.1016/j.jtha.2023.10.012. Online ahead of print.

NO ABSTRACT

PMID:37866514 | DOI:10.1016/j.jtha.2023.10.012

00:03

PubMed articles on: Cancer & VTE/PE

Catheter Directed Thrombectomy and Other Deep Venous Interventions in Cancer Patients

Tech Vasc Interv Radiol. 2023 Jun;26(2):100900. doi: 10.1016/j.tvir.2023.100900. Epub 2023 Aug 5.

ABSTRACT

Treating cancer patients with deep venous thrombosis/venous thromboembolism (DVT/VTE) can be challenging as patients are frequently unable to receive the standard therapy of anticoagulation due to the increased risk of bleeding complications seen in this population. Similarly, the hesitation of interventionalists to use thrombolytic agents due to bleeding risks limits percutaneous intervention options as well. Further, outcome data and guidelines do not exist for oncologic patients and often treatment is tailored to patient-specific factors after multidisciplinary discussion. This article reviews specific factors to consider when planning percutaneous treatment of cancer patients with DVT/VTE, focusing on the iliocaval system.

PMID:37865450 | DOI:10.1016/j.tvir.2023.100900

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PubMed articles on: Cardio-Oncology

Detection of Early Myocardial Dysfunction by Imaging Biomarkers in Cancer Patients Undergoing Photon Beam vs. Proton Beam Radiotherapy: A Prospective Study

J Cardiovasc Dev Dis. 2023 Oct 4;10(10):418. doi: 10.3390/jcdd10100418.

ABSTRACT

1. Background: We sought to determine acute and subacute changes in cardiac function after proton beam (PBT) and photon beam (PhT) radiotherapy (RT) using conventional and two-dimensional speckle tracking echocardiography (2D-STE) in patients with malignant breast and thoracic tumors. 2. Methods: Between March 2016 and March 2017, 70 patients with breast or thoracic cancer were prospectively enrolled and underwent transthoracic echocardiography with comprehensive strain analysis at pretreatment, mid-treatment, end of treatment, and 3 months after RT. 3. Results: PBT was used to treat 44 patients; PhT 26 patients. Mean ± SD age was 55 ± 12 years; most patients (93%) were women. The median (interquartile range) of the mean heart dose was lower in the PBT than the PhT group (47 [27-79] vs. 217 [120-596] cGy, respectively; p < 0.001). Ejection fraction did not change in either group. Only the PhT group had reduced systolic tissue Doppler velocities at 3 months. 2D-STE showed changes in endocardial and epicardial longitudinal, radial, and circumferential early diastolic strain rate (SRe) in patients undergoing PhT (global longitudinal SRe, pretreatment vs. end of treatment (p = 0.04); global circumferential SRe, pretreatment vs. at 3-month follow-up (p = 0.003); global radial SRe, pretreatment vs. at 3-month follow-up (p = 0.02) for endocardial values). Epicardial strain values decreased significantly only in patients treated with PhT. Patients in the PhT group had a significant decrease in epicardial global longitudinal systolic strain rate (GLSRs) (epicardial GLSRs, at baseline vs. at end of treatment [p = 0.009]) and in GCSRe and GRSRe (epicardial GCSRe, at baseline vs. at 3-month follow-up (p = 0.02); epicardial GRSRe, at baseline vs. at 3-month follow-up (p = 0.03)) during treatment and follow-up. No changes on 2D-STE were detected in the PBT group. 4. Conclusions: Patients who underwent PhT but not PBT had reduced tissue Doppler velocities and SRe values during follow-up, suggesting early myocardial relaxation abnormalities. PBT shows promise as a cardiac-sparing RT technology.

PMID:37887865 | PMC:PMC10607871 | DOI:10.3390/jcdd10100418

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PubMed articles on: Cardio-Oncology

Circulating Cardiovascular Biomarkers in Cancer Therapeutics-Related Cardiotoxicity: Review of Critical Challenges, Solutions, and Future Directions

J Am Heart Assoc. 2023 Oct 27:e029574. doi: 10.1161/JAHA.123.029574. Online ahead of print.

 

ABSTRACT

BACKGROUND: The safety and efficacy of direct-acting oral anticoagulants (DOACs) for therapeutic anticoagulation in the setting of primary or metastatic brain cancer is not known.

OBJECTIVE: To conduct a meta-analysis and systematic review of studies that compare the risk of intracranial hemorrhage (ICH) in patients with brain cancer treated with DOACs vs. LMWH.

METHODS: A literature search was conducted using PubMed, EMBASE, and Cochrane databases. Summary statistics were obtained by calculating the risk ratio (RR), and heterogeneity across studies was estimated using the I2 statistic. A total of 10 retrospective studies (n=1,638) met criteria for inclusion. The primary endpoint was the pooled RR for ICH in patients with brain tumors receiving anticoagulation with DOACs compared with those receiving LMWH. Secondary analyses included the risk of fatal ICH in each subgroup.

RESULTS: The pooled RR for ICH in patients receiving DOACs vs. those receiving LMWH was 0.65 (95% confidence interval [CI], 0.36-1.17; P = 0.15; I2 = 50%). In studies evaluating primary brain cancer, there was a reduction in risk of ICH with DOACs (RR, 0.35; 95% CI, 0.18-0.69; P = 0.003; I2 = 0%). In patients with metastatic brain cancer, there was no difference in the risk of ICH with type of anticoagulation (RR, 1.05; 95% CI, 0.71-1.56; P = 0.80; I2 = 0%). The overall risk of fatal ICH was not different between anticoagulants.

DISCUSSION: The risk of ICH in patients with brain cancer receiving therapeutic anticoagulation varies by anticoagulation agent and diagnosis of primary or metastatic disease.

PMID:37866517 | DOI:10.1016/j.jtha.2023.10.011

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PubMed articles on: Cardio-Oncology

Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity

Cell Biol Toxicol. 2023 Oct 27. doi: 10.1007/s10565-023-09835-4. Online ahead of print.

 

ABSTRACT

Survival with operable breast cancer has improved markedly in recent decades, however, treatment-related cardiovascular toxicities threaten to offset these gains. Ovarian function suppression paired with aromatase inhibition, for premenopausal women with hormone receptor (HR)-positive breast cancer, is a newer widely adopted therapy with the potential for significant long-term cardiovascular toxicity. Abrupt estrogen deprivation for non-cancer reasons is associated with accelerated coronary artery disease. Women with breast cancer treated with aromatase inhibition in addition to ovarian function suppression experience a dual hit with regards to estrogen exposure. The CaRdiac Outcomes With Near-complete estrogen deprivation (CROWN) study seeks to understand the early, subclinical natural history of cardiovascular compromise in young women undergoing near-complete estrogen deprivation (NCED) therapy. It is critical to understand the early subclinical development of cardiovascular disease to identify a window for therapeutic intervention before overt cardiovascular events occur. This three-site regional study (Atrium Health Wake Forest, Duke, and Virginia Commonwealth University) uses serial stress cardiac magnetic resonance (CMR) imaging and cardiac computed tomography angiography (CCTA) obtained during the initial two years of NCED therapy to study myocardial prefusion reserve (MPR), large cardiovascular vessel changes, left ventricular function, and other cardiovascular parameters. The CROWN cohort will consist of 90 premenopausal women with breast cancer, 67 with HR-positive disease receiving NCED and 23 comparators with HR-negative disease. Participants will undergo three annual CMR scans and two CCTA scans during the two-year study period. After initial activation hurdles, accrual has been brisk, and the study is expected to complete accrual in December 2024. Efforts are in place to encourage participant retention with the study primary outcome, change in MPR between the two groups, to be reported in 2026-2027. The results of this study will enable premenopausal women with breast cancer to balance the health burdens of cancer at a young age and treatment-related cardiovascular morbidity. Finally, the tools developed here can be utilized to study cardiovascular risk across a range of cancer types and cancer therapies with the ultimate goals of both developing generalizable risk stratification tools as well as validating interventions which prevent overt cardiovascular compromise.

PMID:37890547 | DOI:10.1016/j.ahj.2023.10.007

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PubMed articles on: Cancer & VTE/PE

Comparison of Direct Oral Anticoagulants versus Low Molecular Weight Heparin in Primary and Metastatic Brain Cancers: A Meta-Analysis and Systematic Review

J Thromb Haemost. 2023 Oct 20:S1538-7836(23)00779-1. doi: 10.1016/j.jtha.2023.10.011. Online ahead of print.

 

ABSTRACT

BACKGROUND Pulmonary embolism secondary to deep vein thrombosis (DVT) with cor pulmonale is commonly associated with risk factors including surgery, cancer, and prolonged immobility. Cocaine is known to cause vasoconstriction and has a prothrombotic effect. Prolonged and heavy use of cocaine can also cause inflammation and liver damage. However, data on its potential role in causing pulmonary embolism and direct hepatotoxicity in cases of episodic use are scarce. CASE REPORT A 34-year-old man with no significant medical history except for episodic cocaine use presented in respiratory distress. Workup revealed submassive pulmonary embolism with pulmonary infarctions complicated by pneumonia, hypoxemic respiratory failure, and anemia. He was treated with anticoagulation and intensive care. On day 5 of hospitalization, the patient had an acute hepatic injury. His alanine aminotransferase level peaked at over 2000 IU/L on day 7, until finally tapering. Liver failure was found to be secondary to cocaine use. Liver enzyme levels improved with supportive care. He was discharged with apixaban and continued liver enzyme monitoring. CONCLUSIONS When investigating the cause of venous thromboembolism and transaminitis, evaluating cocaine use via patient history or laboratory analysis of cocaine and its metabolites should be considered. Cocaine is known to cause vasoconstriction and has a prothrombotic effect, although data on its potential role in causing pulmonary embolism and direct hepatotoxicity in cases of episodic use are scarce. Further investigation, such as cohort studies, could help strengthen our understanding of the relationship between cocaine use, acute hepatic injury, and pulmonary embolism.

PMID:37872733 | DOI:10.12659/AJCR.941360

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PubMed articles on: Cardio-Oncology

Cardiovascular Impact of Near Complete Estrogen Deprivation in Premenopausal Women with Breast Cancer: The CROWN Study

Am Heart J. 2023 Oct 25:S0002-8703(23)00300-9. doi: 10.1016/j.ahj.2023.10.007. Online ahead of print.