Independent Medical Alliance 09.12.2023 22:35:36

In this latest episode of ‘Long Story Short’, @ drbeen_medical shares a study demonstrating reduced serotonin levels in long COVID patients - and potential treatments to rescue serotonin levels. Watch now.

https://covid19criticalcare.com/courses/long-story-short-with-dr-been/lessons/long-story-short-episode-81/

Join🔹@Covid19_Critical

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Dr. Shankara Chetty 11.12.2023 19:30:17

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A 2017 study found that vaccinated children had a higher rate of allergies and neurodevelopmental disorders (NDD) compared to unvaccinated children.

In a 2020 study, pediatrician Dr. Paul Thomas studied the effects of vaccination among patients at his practice who had received between one to 40 vaccines. While 0.063 percent of vaccinated participants had attention deficit hyperactivity disorder (ADHD), none of the unvaccinated individuals were found suffering from the disorder.

Another study in 2020 found that vaccination before the age of one year was associated with increased odds of developmental delays, asthma, and ear infections.

Being on the childhood vaccine schedule is an evergreen business. As a parent, you owe it to your child to check the validity of any vaccine regardless of what the pediatrician said.

Join ➡️ @ShankaraChetty

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Dr. Shankara Chetty 12.12.2023 19:31:37

This is bigger than COVID: Why are so many Americans dying early? | The Hill - Pierre Kory & Mary Beth Pfeiffer

"Life insurers have been consistently sounding the alarm over these unexpected or, “excess,” deaths, which claimed 158,000 more Americans in the first nine months of 2023 than in the same period in 2019. That exceeds America’s combined losses from every war since Vietnam. Congress should urgently work with insurance experts to investigate this troubling trend. 

With the worst of COVID behind us, annual deaths for all causes should be back to pre-pandemic levels — or even lower because of the loss of so many sick and infirm Americans. Instead, the death toll remains “alarming,” “disturbing,” and deserving of “urgent attention,” according to insurance industry articles.

Actuarial reports — used by insurers to inform decisions — show deaths occurring disproportionately among young working-age people. Nonetheless, America’s chief health manager, the U.S. Centers for Disease Control and Prevention, opted in September to archive its excess deaths webpage with a note stating, “these datasets will no longer be updated.” 

Vaccines were given to more than 270 million people, among them babies, pregnant women and workers under employer mandates. The therapeutic’s “warp speed,” emergency use authorization must be part of any post-pandemic analysis, in light of more than 1 million reports of possible harm to the Vaccine Adverse Events Reporting System and a new Yale University study validating a chronic post-vaccination syndrome."

https://thehill.com/opinion/healthcare/4354004-this-is-bigger-than-covid-why-are-so-many-americans-dying-early/

Join ➡️ @ShankaraChetty

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Dr. Shankara Chetty 13.12.2023 14:18:05

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Can the COVID shots change the DNA in your body?

"Yes, that's a distinct possibility," says Dr. James Thorp. "This has been proven in vitro, meaning in the laboratory."

Even worse, Denis Rancourt has recently published a paper, in which he estimates that 17 million deaths worldwide are causally connected to the COVID-19 injections.

Join ➡️ @ShankaraChetty

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The KINGDOM ORACLE 🔥 13.12.2023 18:40:40

JULIE GREEN MINISTRIES:

Join Julie Green, Marty Grisham, and Amanda Grace for the Outdoor Prayer Rally on December 14, 2023, at 3:30 pm Pacific time.

See you there!

https://rumble.com/v40wmuh-governmental-scandals-are-being-exposed-like-never-before.html

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Donald J. Trump 13.12.2023 12:53:06

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Thank you, John Daly!

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Prophecies Fulfilled 10.12.2023 16:52:43

JESUS IS YOUR VICTORY

Word Received: December 22, 2021

My children, during this time of celebrating the birth of your Lord and Savior, let joy fill your hearts and receive the joy I am giving to you. Receive My goodness and Glory which I am raining down in this hour for My children.

And for My children who have chosen NOT to stand and NOT to believe My prophets any longer, for those who waved their white flags because of discouragement and disappointment, I am giving you another chance: to choose life and to choose to believe My Words and My prophets. I put them on this Earth for such a time as this: to encourage you, to get you back up and to take you out from that spirit of defeat which kept you enslaved. Put your hands up this day and receive from Me in a new way. Get rid of those past disappointments brought on by the lies your enemy kept you bound with.

I am giving you signs again to show you that I am The Great I AM. But this is the hour of choosing which side you are on. These are the final days and hours for you to choose what you believe: Me or your adversary and his lies. For My children who choose to stand, I am pouring out abundance, overflow and more than enough. And during this season, remember My children, that I gave to this Earth My only begotten Son to die for you so you could live an abundant life. And no matter what kind of power your enemy has, I have given you My Son. He destroyed satan's power and control over you. He bore the curse for you. He suffered so you wouldn't have to suffer. If you are suffering today, cry out to Me, My children, and receive My love and the deliverance I have for you this day.

I have heard your cries, and I have seen the attacks you have been under. The Way Maker is coming to you and making a way, turning your impossible situations around to pick you up when you couldn't get up on your own. I am here to shelter you from the storm and to command peace and justice in your lives.

December 10, 2023: 🕊As that last paragraph states, God is our Way Maker.

No matter what you are going through. He will make a way where there is no way. GOD WINS! Worship Him!

Here is the original song from Sinach. She started this viral song. She also wrote it.

https://www.youtube.com/watch?v=n4XWfwLHeLM

This is Only a Portion of What God is Saying. Follow Link to Full Prophecy in Comments.

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Prophecies Fulfilled 13.12.2023 01:16:38

SHOCKWAVES ARE COMING TO DESTROY YOUR ENEMIES' PLANS

Word Received: June 4th 2022

A political stirrup: it will cause more people on the blue to turn to the red.

December 12, 2023

https://t.me/realKarliBonne/212283

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Prophecies Fulfilled 13.12.2023 04:45:46

EVERYTHING IS ABOUT TO BE OVERTURNED

Word Received: December 15, 2022

I say the word ambassador will be in your news. I have said this many times before. Look at what is being said now.

December 12, 2023

https://t.me/beholdisraelchannel/24546

Hamas head Yihya Sinwar at the UN General Assembly, he says, “if you want a cease fire, call him and tell him to release the hostages and surrender.” No doubt, that is the quickest path to a cease fire!

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Prophecies Fulfilled 13.12.2023 18:53:04

A GREAT AMERICAN REVOLUTION HAS BEGUN

Word Received: March 3, 2023

Another whistleblower has been held back for the right time to bring this fraudulent government and their lies to nothing. Something significant is on the horizon to save this Nation.

THE END TO THE ESTABLISHMENT IN DC

Word Received: August 4, 2023

Jack Smith: the truth is coming for you with things you never thought people would find out about you. I have whistleblowers that will wipe out this indictment, and it will boomerang back on you. These are the days of Haman, and many people are about to find out who the Hamans are and what their final outcome is about to be.

December 13, 2023

https://t.me/realKarliBonne/212515

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Gold Telegraph 13.12.2023 19:04:16

Imagine waking up, and the value of your currency was cut in half overnight.

This is the reality for the people of Argentina.

This is why you have some gold.

Read: https://x.com/goldtelegraph_/status/1734997469703066104?s=46

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Health Ranger 13.12.2023 19:02:30

Brighteon Broadcast News, Dec 13, 2023 - “Leave the World Behind” movie foreshadows massive cyber attack false flag event to come

- The new Netflix movie, immigration, racial tension.

- #Censorship, AI, and Leave the World Behind.

- Film characters and their racial dynamics. (10:11)

- Cyber attacks and #falseflag operations. (49:13)

- Geopolitical events and potential threats with Colonel Tony Shaffer. (1:11:13)

- Russia-Ukraine conflict and its impact on Europe. (1:24:21)

- Energy policy and #climate change. (1:32:55)

- Firearms, military contracts, and US foreign policy. (1:46:52)

- Politics, media, and energy infrastructure. (1:58:55)

https://www.brighteon.com/2ec01303-d10e-4d23-9ade-4518aa3bf8ed

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Chat: Kingdom Jubilee Media❤️ 13.12.2023 19:17:50

https://open.substack.com/pub/makismd/p/video-california-covid-nurse-exposes

.

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And We Know® 13.12.2023 19:14:22

12.13.23: Breuer exposes EVIL, PP exposed, MSM removing archives-too late, Chicago, Etsy, Milei bad? Pray!

Watch on Rumble: http://tinyurl.com/msrz7z6j

➤ https://andweknow.com

➤ https://thepatriotlight.com

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Prof.Dr.Stefan Hockertz Original Wissenschaft 12.12.2023 23:52:59

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Mikael Hagenbo 13.12.2023 17:07:45

https://open.substack.com/pub/makismd/p/summer-of-died-suddenly-families?r=17ikr9&utm_medium=ios&utm_campaign=post

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Total Disclosure 13.12.2023 17:41:36

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ZIONISM: Barbara Spectre brags about how HER people have created a thriving nationalist culture in the U.S. and Israel. Within the same video, she highlights why HER people need to destroy European nationalism in the West. Barbara is one of many Jewish activists who employ double standards.

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The KINGDOM ORACLE 🔥 13.12.2023 18:04:39

Robin D Bullock: 2 Kings, 1 Removed | Prophecy 12/12/2023

Watch 1h

https://youtu.be/SXNELDOJ8c4

🕊 t.me/TheKingdomOracle

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The KINGDOM ORACLE 🔥 13.12.2023 20:31:51

Hank Kunneman: Righteous Removal

37m

https://youtu.be/GV97s4_RX3I

🕊 t.me/TheKingdomOracle

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Kingdom Jubilee Media ♥️ #StandsWithTrump 13.12.2023 20:41:08

E:

There is more to Tara Reade than meets the eye.

Her story, because it is true, carries a unique weight. There will come a day when her feet will return, when her story will be told. When the countless victims of Joseph Biden's unwanted sexual advances will speak before the world plainly.

-

Fight for that day.

-

https://twitter.com/RadhaStirling/status/1734436668755546349

President Biden just declared himself a Zionist at a Whitehouse Hanukkah celebration.

-

This is more important than you realize.

The sitting U.S. President has openly committed fealty to an ideological movement based on the superiority of a foreign power and people. One that is openly hostile to U.S interests.

The death toll in Gaza has surpassed 20,000 people. More than 90% of whom are civilians constituting largely of women and children.

This is in only a few weeks.

With more than 6,000 bombs dropping a day, weeks on end (mostly provided by the United States), genocide is not the word.

The Israelis are engaged in open ethnic extermination.

Join us. Live now.

https://twitter.com/TuckerCarlson/status/1734744706255290718

Nearly 1 million people tuned in live.

Well done.

.

Listen to me carefully.

When I say you are ruled by perception,

It goes deeper than you imagine.

What do you imagine yourself to be?

Are you a single breathing thing? A sole soul breathing out. Or are you defined by the trillions of pieces that make up your existence? Does each cell within a cell think? Does each quark dream?

You percieve yourself in a way that is not entirely true.

You are not one thing.

You are many.

And like the many things that make you up, you too are parts of something greater that you cannot yet percieve.

-

Take a moment and strip away the confines.

Ask yourself, what limits you?

Where are your walls set, and why?

Who determined for you, how things should be?

Who determines what weight and effect you have on the world around you?

-

-

You are quite marvelous things, you would be surprised what even one of you might accomplish if you understood.

-E

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Follow 🕊 t.me/KingdomJubileeMedia

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Mr. Pool 13.12.2023 00:10:06

Now, prepare for something that you never expected to see in your lifetime.

Next chapters..

- (9/10) 🎥

- (10/10) 📑

Warning: After 48 hours the channel will be locked. Uncensored videos follow.

Closing the curtain!

Get behind her, everyone.

Join, it's not too late! 👇

https://t.me/Official_MrPool

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Shadow of Ezra 13.12.2023 02:03:47

The power of honesty is immeasurable. ☝️

Watch out for that!

@ShadowEzra1

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WorldTribune 12.12.2023 00:33:58

... The rundown:

• “multi-national law firm” = Boies Schiller Flexner, LLP

• “Business Associate 1” = Rob Walker

• “G.P.” = Gabriel POPOVICIU

• “Business Associate 2” = James GILLIAR

• “the Chairman” = YE Jianming

• “Business Associate 3” = James Biden

...

https://www.worldtribune.com/unredacted-the-whos-who-in-the-hunter-biden-indictments/

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Garrett Ziegler 07.12.2023 06:33:20

We're gonna win. Are you with me? FightBiden.org

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Truth Fighters 07.12.2023 23:55:11

TRUMP REVEALS ‘THE ONLY GLOBAL WARMING WE SHOULD BE THINKING ABOUT’

https://www.truth-fighters.com/2023/12/07/trump-reveals-the-only-global-warming-we-should-be-thinking-about/

Join Truth Fighters for the uncensored truth

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The KINGDOM ORACLE 🔥 13.12.2023 18:04:39

Robin D Bullock: 2 Kings, 1 Removed | Prophecy 12/12/2023

Watch 1h

https://youtu.be/SXNELDOJ8c4

🕊 t.me/TheKingdomOracle

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The KINGDOM ORACLE 🔥 13.12.2023 20:31:51

Hank Kunneman: Righteous Removal

37m

https://youtu.be/GV97s4_RX3I

🕊 t.me/TheKingdomOracle

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OutsideTheMatrix 13.12.2023 21:55:57

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Aaaand... Hunter skips his deposition

Where's Hunter 😂 😂 😂

Follow: OutsideTheMatrix ✅

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The KINGDOM ORACLE 🔥 13.12.2023 23:24:00

Hank Kunneman: Divine Reset, Divine Reversal | Prophetic Word and Teaching

Watch

https://m.youtube.com/watch?v=U_dX4l2Imro&pp=QAFIAw%3D%3D

🕊 t.me/KingdomJubileeMedia

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il Donaldo Trumpo 12.12.2023 20:47:20

THEY'RE FACT-CHECKING MEMES NOW!!!😭🤣🤣🤣

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il Donaldo Trumpo 12.12.2023 22:58:34

EVEN SANTA NEEDS DADDY TRUMP BACK!!!🎅🎄🎄🎄

https://rumble.com/v40xtv5-daddyt.html

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il Donaldo Trumpo 12.12.2023 23:03:40

LOVE THE GANG!!!😎

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il Donaldo Trumpo 12.12.2023 23:34:27

I KNOW WHO TUCKER IS VOTING FOR!!!😎🥳🥳🥳

https://rumble.com/v40y07w-booom.html

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il Donaldo Trumpo 12.12.2023 23:56:45

😂😂😂

https://rumble.com/v40y3re-fjb.html

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il Donaldo Trumpo 13.12.2023 00:53:25

BOOOM!!!😎🥳🥳🥳

https://rumble.com/v40y8x9-lesgooo.html5

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il Donaldo Trumpo 13.12.2023 01:47:52

I LOVE MY FARMERS!!!🤗🤗🤗

https://rumble.com/v40yloe-realove.html

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il Donaldo Trumpo 13.12.2023 02:01:46

THE BEST!!!😂🎄🎄🎄

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il Donaldo Trumpo 13.12.2023 03:05:01

BOOOM!!!😂🔥🔥🔥

https://rumble.com/v40yxpq-fjb.html

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il Donaldo Trumpo 13.12.2023 03:14:49

THEY KNOW IT'S COMING!!!🥳🥳🥳

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il Donaldo Trumpo 13.12.2023 20:46:45

HUNTER... YOU'RE A LOSER!!!

https://rumble.com/v413ff7-fjb.html

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il Donaldo Trumpo 13.12.2023 22:06:48

JAIL THE BIDEN CRIME FAMILY!!!

https://rumble.com/v413wog-fjb.html

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il Donaldo Trumpo 13.12.2023 22:10:48

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il Donaldo Trumpo 13.12.2023 22:38:14

NOTHING CAN STOP WHAT'S COMING!!!😎🥳🥳🥳

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The Yorkshire Lass 13.12.2023 23:29:59

3 CEMEX plants are near where the explosion happened on an industrial estate in South Wales 20mins ago which felt like an big Earthquake according to witnesses. No coincidence. Feels like something nefarious under there and they are cleaning up! And this on the same day Pedo Drakeford announces his resignation🤔

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Traditional Britain Group 13.12.2023 15:02:20

Maybe he should have spoken up earlier? And the 'controlled immigration' his party has given us has added over 1m new people to the population over the past year.

Immigration is turning parts of the UK into a “ghetto” where no-one speaks English, a Conservative MP has said.

Nick Fletcher said Doncaster was full and that immigration needs to be tackled as the Safety of Rwanda (Asylum and Immigration) Bill was read for a second time.

In a speech which drew gasps and shouts of “shocking” from the Labour backbenches, Mr Fletcher said people “don’t expect to be called racist or xenophobic for saying ‘we liked it as it was'”.

He added: “If we’re going to have immigration, which I don’t completely believe is a bad thing to do, it just needs to be controlled immigration.”

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Arthur Braine 12.12.2023 20:55:18

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il Donaldo Trumpo 13.12.2023 23:40:16

https://t.co/IvTOsIe52i

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Trump Office 13.12.2023 23:43:15

Join the Trump Office Telegram channel

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23:58

World News

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🇺🇸🇬🇧 RedPillBoy 12.12.2023 22:43:20

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https://vm.tiktok.com/ZGeLAMQ7G/

14 December 2023

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Rise of the Global South 13.12.2023 23:40:10

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🔴 DEVELOPING: Police in Wales, UK Responding to “Serious Incident” after Reports of Huge Explosion at Industrial Estate

@RiseGS

🔥

CG

CG

04:35

Christina Goerss

#WeThePeople are LIVE in the PowerGirl Multiverse NOW https://rumble.com/v413tu0-future-proves-past-a-freedom-fighter-retrospective-wethepeople-are-the-plan.html

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Total Disclosure 14.12.2023 10:19:35

 

Julian Assange 13.12.2023 16:03:56

Message to all conspiracy theorists and curators

To all of you who have spent years being ridiculed on social media and being called "crazy" and still standing up for what you believe in and trying to spread the truth to the public. L

You lose friends and family, and despite being ridiculed, you speak the truth.

To all the lightworkers, starseeds, wayshowers, and alternative therapists who have always felt left out and different but never stopped being people who tried to offer another perspective on things.

I learned about energy healing, crystals, Mother Gaia, and healing therapies while everyone around me laughed.

You were different, you were eccentric, and you never adapted or adapted to this situation without regret.

For sensitive people who are heartbroken after learning about human trafficking, pedophile rings, and harm to children.

The woke people who realized what was going on in the world and had to break their hearts into a million pieces while thinking everyone in their lives was losing their minds. You had to face all this alone and it broke your heart, but you made it through and faced the dark night of the soul!!

To the old souls who feel alone and different, who strive every day to help humanity who have lost many friends and family in the process of awakening.

The people who don't go out anymore, the people who research till the end of the day, the people who dare to stand up and say things that no one else would say. >>>>>>>

You have dedicated your life to this ascension process. >>>>>>>

I respect each and every one of you. >>>>>>>

This process is the hardest thing anyone has ever had to do, but you did it first. >>>>>>>

Every day more and more people are waking up. >>>>>>>

I know it's hard and I know you can be exhausted and exhausted by the negative reactions you're getting, but this fight will be over soon and soon the world will realize what we did. , and stay strong because you will find out why you did it. >>>>>>>

Where one goes, all go too. >>>>>>>

This time will be mentioned in history, and your efforts to awaken and heal humanity will not only affect our existence on Earth, but everything throughout the universe.

This is a galactic event and you chose this task before incarnating into this timeline.

You chose to be here now.

You are a divine being, remember who you are.

Endless blessings.

The best is yet to come.

God is in command.

Subscribe for more:

@WIKILEAKSJULIANASSANGE ✅️

WIKILEAKS EXCLUSIVE

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Tucker Carlson Fans 13.12.2023 17:23:51

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Tucker Carlson War Room - Part 1

Subscribe: Tucker Carlson

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Tucker Carlson Fans 13.12.2023 17:41:18

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Tucker Carlson War Room - Part 2

Subscribe: Tucker Carlson

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Trump Office 13.12.2023 17:56:51

BREAKING NEWS: The Supreme Court said Wednesday it will hear an appeal that could upend hundreds of charges stemming from the Jan. 6, 2021, attack on the U.S. Capitol, including against former President Donald Trump. MORE: https://bit.ly/3NnDkrS

Join the Trump Office Telegram channel

18:09

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The General 13.12.2023 03:25:30

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WATCH: If there is a cyber attack next year, our government is responsible, just like they were for stealing the 2020 election.

@GeneralMCNews

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The General 13.12.2023 15:56:02

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BREAKING: Hunter Biden speaks at US Capitol, "My father was not financially involved..."

@GeneralMCNews

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The General 13.12.2023 17:11:17

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BREAKING: Media warns if Trump wins next election, the world will come to an end. He will assassinate generals, shoot visitors at the White House, kill the First Lady, Suspend the Constitution, kill democracy, destroy the justice department.

@GeneralMCNews

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Gold Telegraph 13.12.2023 00:12:23

BREAKING NEWS

ARGENTINA HAS DEVALUED THE PESO BY 54%

54% of purchasing power gone with the wind.

Read: https://x.com/goldtelegraph_/status/1734708642169975115?s=46

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Gold Telegraph 13.12.2023 18:08:36

“There was a time when every junior had a market cap of over $100 million.”

- Irwin

This is what happens in a good mining market.

It gets wild.

Read: https://x.com/goldtelegraph_/status/1734982987966730721?s=46

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QAnon Warriors 12.12.2023 22:45:24

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McDonalds opens its first fully automated restaurant. Part of the great reset is to phase out human labour.

Join: John F. Kennedy Jr. ⚡️

18:13

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QAnon Warriors 13.12.2023 15:34:01

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— UKRAINIAN MILITARY OFFICER REVEALS HOW THE CIA WAS BEHIND THE 2014 COUP THAT SAW THE REMOVAL OF PRESIDENT VIKTOR YANUKOVYCH —

Join: John F. Kennedy Jr. ⚡️

18:13

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We The People 12.12.2023 22:46:01

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Did you know that 4 journalists that exposed the elite PED0PHILE network connected to celebrities, politicians, billionaires and pizzagate died mysteriously? Is that why this video was originally removed from the internet?

Join: John F. Kennedy Jr. ⚡️

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We The People 13.12.2023 15:29:01

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Graphene Oxide nanoparticles found in Sanpellegrino water.

Join: John F. Kennedy Jr. ⚡️

18:14

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Edward Snowden 13.12.2023 15:27:01

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NASA's Fake Green Screen Stars Exposed

Join: John F. Kennedy Jr. ⚡️

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Dan Scavino 12.12.2023 22:29:01

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MAKE AMERICA GREAT AGAIN, AGAIN!

Join: John F. Kennedy Jr. ⚡️

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Dan Scavino 13.12.2023 15:27:01

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Kid Rock Calls Donald Trump "The Toughest Son of a Bit*h on Earth"

"To me, he's the greatest president we've had."

"I don't know how you look at his track record and what he did and how he had this country fired on all cylinders when he was in office."

Join: John F. Kennedy Jr. ⚡️

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White Hats 12.12.2023 22:22:01

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There shouldn't be any incidents   vaccines are supposed to be 99.99999% safe.

Join: John F. Kennedy Jr. ⚡️

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White Hats 13.12.2023 15:21:01

The New Netflix movie called "Leave The World Behind" was produced by Barack and Michelle Obama.

The movie shows how a cyberattack caused a major blackout in the United States.

When globalists including

Jeremy Jurgens (WEF) & Klaus Schwab speak repeatedly of cyber doom, you can be sure they're telling you their plans.

Klaus Schwab-Rothschild :

"The change is not just happening, the change can be shaped, by us.

I see the need for a great reset.

The Covid-19 crisis would be seen as a small disturbance in comparison to a major cyber attack."

Join: John F. Kennedy Jr. ⚡️

18:15

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White Hats 13.12.2023 15:21:01

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White Hats 13.12.2023 15:21:01

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X22 Report Official 13.12.2023 15:02:01

They already have it planned

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Disclose.tv 13.12.2023 13:23:24

JUST IN - Chancellor Scholz: "Should the situation deteriorate due to Russia's war in Ukraine," the government may declare an "extraordinary emergency situation" in Germany.

Opposition leader Merz (CDU): "It is a predictable emergency that you must declare by the middle of the year at the latest... We won't let you get away with this trick, Mr. Chancellor."

@disclosetv

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X22 Report Official 13.12.2023 15:19:53

https://x.com/CBS_Herridge/status/1734682027558056272?s=20

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Ezra A. Cohen 12.12.2023 21:14:01

Soros Family in Ukraine.

No Zelensky in sight.

Join: John F. Kennedy Jr. ⚡️

18:32

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Ezra A. Cohen 13.12.2023 15:16:01

Children are being sold on Etsy right now.

These children are being trafficked to Martha's vineyard.

Guess who lives there?

The Obamas

Join: John F. Kennedy Jr. ⚡️

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Jeffrey Peterson - jeff.pro 13.12.2023 00:13:43

I don't get it. Section 702 shouldn't even be a debate. No more warrantless spying on Americans. End of story.

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Jeffrey Peterson - jeff.pro 13.12.2023 15:03:36

The political left likes to use data. They pull data from as many places as they can, trying to project outcomes, using a variety of methods and tactics for statistical modeling they believe superior to others. I know a lot about this first hand, from a prior life.

Anyway, I've been running a good amount of data recently, myself.

According to a good deal of analysis, many data points and model scenarios, I truly believe Donald Trump will be elected President of the United States, again, in 2024.

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Kayleigh McEnany 12.12.2023 21:02:01

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Impeachment inquiry

https://t.me/+WijoiuEYEyRhMzJh

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Kayleigh McEnany 13.12.2023 15:01:13

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Never Nikki

https://t.me/+WijoiuEYEyRhMzJh

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LauraAboli 12.12.2023 19:36:56

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🇫🇷 Taxis are carrying out snail operations throughout France to protest against a reform of medical transport. Traffic is very disrupted in Toulouse during Emmanuel Macron's visit.

https://t.me/LauraAbolichannel

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LauraAboli 12.12.2023 19:54:41

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13 years of Conservatives ‘reducing immigration’… 🤦🏻‍♀️

https://t.me/LauraAbolichannel

13 December 2023

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Mark Collett 05.12.2023 23:19:38

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Is Mark Steyn finally getting it?

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Disclose.tv 11.12.2023 17:29:55

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NEW - Netflix's "Leave the World Behind" cyber apocalypse movie warns about "white people" if "the world falls apart."

Not only did Barack Obama help executive produce the movie as part of Higher Ground, but he personally helped shape the script by giving its screenwriter notes, according to HITC.

@disclosetv

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00:40

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Mark Collett 12.12.2023 07:36:23

Europe's beautiful art will eventually disappear thanks to demographic change.

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Norbert 12.12.2023 16:18:14

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Italian Health Minister Gave Orders To Conceal Vaccination Deaths – Now Under Investigation For Murder ☠️

The flood gates are opening...

A

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Zeee Media 🎙 13.12.2023 02:26:11

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🚨Reese Report🚨

Italian Health Minister Gave Orders To Conceal Vaccination Deaths – Now Under Investigation For Murder.

Burnnnn baby, burn!!!

Follow @zeeemedia

Website | X | Instagram | Rumble

16:33

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Dr Jane Ruby 13.12.2023 16:29:00

🔥 THE FDA IS OPERATING ILLEGALLY

If the C19 "vaccine" injections are not pharmaceutical products, and therefore NOT subject to the standard FDA regulations and requirements for safety and efficacy clinical trial data, under the public health emergency and EUA

Then by what authority does the @US_FDA make ANY decisions, authorization or approval of these injections?

They can't have it both ways

@sasha_latypova

@MCBashaw

https://www.fda.gov/news-events/press-announcements/fda-takes-action-updated-mrna-covid-19-vaccines-better-protect-against-currently-circulating

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Quantum Medicine ️⚡ 16.11.2023 10:23:55

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THIS IS WHATS HAPPENS TO YOUR BLOOD WHEN YOU TAKE YOUR SHOES OF AND START GROUNDING!

Follow: Quantum Medicine ✅️

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Alternative Medicine 13.12.2023 12:08:45

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How to Keep your Teeth healthy, without harmful chemicals!

With this info you will be able to fix your dental problems quickly

Cause these are the most powerful ancient tools used for optimal oral health

🤔 Know When and How you should use them?

🥥 COCONUT OIL :

– Few x per week - up to 3x a day

🤎 CLOVE OIL :

– Mostly used when necessary for toothache, Can be added to a toothpaste for antibacterial toothpaste

🖤 BLACK SEED OIL :

– It can cure gum disease, toothache, tooth infection, also good for oil pulling, can be just eaten, 2,5ml (1/2 tsp) per day

🏆 BEST ALTERNATIVES :

• Oil of Oregano slows the growth of cavities & prevent further decay

• Establish a Healthy pH Level with Xylitol

• Drink Green Tea to Remineralize weak enamel

🚨 Always REMEMBER to get as organic as possible

Follow: AlternativeMedicine ✅️

16:37

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Robin Monotti ( + Cory Morningstar ) 13.12.2023 07:17:37

A reminder of the legal duty to Informed Consent for all medical practitioners.

➡️ t.me/RobinMG

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Alternative Medicine 07.12.2023 02:55:49

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Air Fryers - Di(2-ethylhexyl) phthalate (DEHP) - carcinogenic toxins in air fryers 🔗

Follow: AlternativeMedicine ✅️

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Michelle Evans 13.12.2023 16:06:25

In reply to this message

Be careful you are not grounding in grass sprayed with chemicals. They will be absorbed!

16:46

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Trump Office 12.12.2023 20:40:06

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Tom Fitton: New devastating indictment of what Hunter Biden was up to and confirms that money was flowing overseas into Hunter’s business

Join the Trump Office Telegram channel

16:46

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Trump Office 12.12.2023 22:58:23

THIS IS THE BIGGEST STORY OF THE YEAR, AND REPUBLICANS MUST DO SOMETHING ABOUT IT. DON’T BE MITCH MCCONNELL AND HIS GANG OF RINOS. HAVE TO MAKE A MOVE NOW. GET TOUGH, GET SMART. OUR COUNTRY IS BEING STOLEN! https://heartland.org/opinion/heartland-rasmussen-poll-one-in-five-mail-in-voters-admit-to-committing-at-least-one-kind-of-voter-fraud-during-2020-election/

Join the Trump Office Telegram channel

16:46

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John Durham 12.12.2023 23:54:52

Michael Cohen's bid for early termination of supervised release encounters a roadblock -

His attorneys made up cases in support of Cohen's release.

The Judge noticed: "As far as the Court can tell, none of these cases exist."

"the Court contacted the Clerk of the Court for the United States Court of Appeals for the Second Circuit, who found no record of any of the three decisions"

Cohen's attorney now must explain why he doesn't deserve sanctions.

John Durham

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John Durham 12.12.2023 23:54:53

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Trump Office 13.12.2023 02:36:49

Jack Smith has infringed on President Trump’s First Amendment rights and tried to prevent him from criticizing Biden for bringing this sham prosecution — in the middle of an election

Join the Trump Office Telegram channel

16:46

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Trump Office 13.12.2023 12:03:59

Join the Trump Office Telegram channel

16:46

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Trump Office 13.12.2023 12:04:12

Join the Trump Office Telegram channel

16:46

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Trump Office 13.12.2023 15:02:46

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Croatian MEP, Mislav Kolakušić, to the EU parliament: The EU is using the #ClimateScam as an pretext to seize agricultural land from farmers, with the ultimate goal of creating deliberate food shortages.

Remember, starving and desperate people are a lot more likely to comply with tyranny, in exchange for enough calories to avoid death, than people with easy access to an abundance of food, even if the source of those calories is insects—or fake, lab-grown "meat".

Join the Trump Office Telegram channel

16:46

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Trump Office 13.12.2023 16:12:31

JUST IN - U.S. Supreme Court will hear a case that could undo Capitol riot charge against hundreds, including Trump.

https://www.disclose.tv/id/q2ntyf4l16/

Join the Trump Office Telegram channel

16:57

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Kingdom Jubilee Media ♥️ #StandsWithTrump 13.12.2023 16:50:38

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NEW - Netflix's "Leave the World Behind" cyber apocalypse movie warns about "white people" if "the world falls apart."

Not only did Barack Obama help executive produce the movie as part of Higher Ground, but he personally helped shape the script by giving its screenwriter notes, according to HITC.

@disclosetv

-

Children of [HaSatan] attempting to use religion to bring about Luci-fer desires of extinction of creations now #ButGOD 🤣

Watch 2m https://youtu.be/cMVBi_e8o-Y

Let's DECREE:

It's their end and not ours!!!

We've won they've lost!!!

YAHSHUAH reigns no matter what they do, HalleluYAH 💨🌊⚡️

It's our Jubilee and abundant life blood bought by YAHSHUAH'S BLOOD COVENANT and finished works amen and amen HalleluYAH 🙌🔥❤️

Follow 🕊 t.me/KingdomJubileeMedia

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HATS 🎩 12.12.2023 10:41:20

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Humanity’s DNA is made originally by the creator, unaltered & untouched by mans science. The unvaccinated are the only pure bloods left on the whole entire planet earth.

If you have been vaccinated you have allowed these new nimrods to change your DNA. If vaccinated your body will never be the same, you cannot reverse gene therapy once injected with mRNA technology.

Subscribe to @HATSTRUTH 🎩

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Kingdom Jubilee Media ♥️ #StandsWithTrump 13.12.2023 17:16:31

Eggs 🥚 and Meat 🍖 for body builders and not protein powder shakes - should you eat more whole eggs ⁉️👍

7m

https://youtu.be/2y-jdh6g1y0

Recommended by many natural health supporters: minimum 5 a day for maintenance and around 25 a day for repair

A famous body builder in 1950s ate 30 eggs 🥚 and unlimited meats. This guy in the video eats 5 thrice daily, totalling 15 and meat 🍖

Cholesterol myths debunked with scientific evidence by Dr Stella Ekberg 4:40 👍

BTW, I now eat 5 eggs 🥚 daily and more when traveling 👍

#LightBe #TRUTHthatSetFREE

🕊 t.me/KingdomJubileeMedia

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HATS 🎩 12.12.2023 10:41:20

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Humanity’s DNA is made originally by the creator, unaltered & untouched by mans science. The unvaccinated are the only pure bloods left on the whole entire planet earth.

If you have been vaccinated you have allowed these new nimrods to change your DNA. If vaccinated your body will never be the same, you cannot reverse gene therapy once injected with mRNA technology.

Subscribe to @HATSTRUTH 🎩

17:35

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Down the Rabbit Hole 12.12.2023 21:17:06

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Did you know that CPS is one of the alleged leaders in human trafficking⁉️ It could be why this footage was removed.

Join and share 👇

http://t.me/+NI0TIwRKGlBkYzVk

17:35

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Down the Rabbit Hole 13.12.2023 01:37:06

DISMANTLING of NATO< UN

I have told you many many times TURKEY is playing against NATO and making secret moves and they are Allied with Russia and china.

_NOW The President of Turkey >Erdogan, has publicly come out in support of Palestinians in the ongoing HAMAS-Israel conflict and has PUBLICLY WARNED ⚠️ the United States to STAY OUT of the conflict.

NATO in shock as NATO leaders know Turkey has sent weapons to Hamas the through the eastern regions. And NATO can not have their NATO allie Turkey threatening another NATO country U.S. ////

NATO( cia mi6. Rothschild etc) in PANIC as support for Ukraine war begans to fall and NOW NATO member Turkey is siding with Palestine Hamas.

__

CABLES>]; NATO CALLS EMERGENCY MEETING ....

( if turkey leaves NATO or other NATO countries vote out Turkey.... Then NATO loose their biggest NATO military allie in Europe and money and weapons... And Surely NATO can not carry on without TURKEY military deserting NATO ALLIANCE)

.. And in return Turkey would publicly join Russia and china alliance<

___

NATO in PANIC as U.S. weapons. To NATO to Ukraine has been TRACKED and showing up in Iran. Iran is buying Ukraine weapons that their military is selling on the black market to enemies of U.S. and NATO allies ..

Iran bought the weapons and gave to hamas

... And Turkey also armed Hamas....

This story will drop soon/////

__

Panic as NATO ( cia etc. ) crumbles slowly

....

WIRES>] JIM JORDAN The coming Speaker of Congress ( placed by Trump. Mil +++) WILL Start to EXPOSE NATO WEAPONS BLACK MARKET TRADE and JORDAN WILL EXPOSÉ UKRAINE money laundering system and connect Biden directly to Ukraine crime syndicate operations.....

TRUMPS CONGRESS IS COMING HARD WITH LOTS OF INFORMATION FOR THE WORLD.....[ DECLAS] ////

HMMMMM 🤔.... Seens like everything was planned 😉

Been telling you back in 2021 JIM JORDAN WAS COMING and Trump was behind him and Congress was going to EXPOSE the world agendas and operations..

>Well it's happening now....

__

Deep State world intelligence communities are in PANIC as TRUMP CARD > EPSTEIN LIST. FILES> will DROP in due time before the 2024 elections..... The show all begins in February 2024>>>>> thank you. Musk. Turker > Kash> Cheyenne mountain commands.

NATO.UN. WORLD BANKS.. GATES ETC ECT EC... ALL INSIDE THE EPSTEIN SERVERS.

______

Be strong Patriots as THE STORM STRENGTHS ...... And deep play all their cards> push for nuclear war. Civil wars. Blackouts. Massive false flag EVENTS...

Counter measures in place....

Game Theory operations.

The war is real. The mews of fake

___

Trump is giving you real COMMS _NOW inside his speechs

Only he can "stop War World III from happening"

_

Hmmmmmmmm is seems like Q The Storm Rider has said this many times since 2021 early on🤔 hmmmm 😉

____

I have been telling you for a long time of all these EVENTS happening for a reason...

Have faith Patriots. God Wins

Subscribe for more:

http://t.me/+NI0TIwRKGlBkYzVk

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Trump Office 13.12.2023 17:12:23

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Rather than follow the lawful subpoena for a deposition issued by Chairman James Comer, Hunter Biden decided to play circus outside the Capitol this morning.

President Trump’s own children sat for hours of depositions after being subpoenaed countless times by the Democrats.

We must immediately move forward to hold Hunter in contempt of Congress.

Join the Trump Office Telegram channel

17:37

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Shadow of Ezra 09.12.2023 16:13:57

12 day til Winter begins.

NO PLANES.

@ShadowofEzra

17:37

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Shadow of Ezra 11.12.2023 14:17:14

Step 1: The Soros family had to make a sudden emergency visit to Ukraine.

Step 2: Zelensky announces peace talks (surrender) in Switzerland via the World Economic Forum.

Step 3: Zelensky will be removed from power.

Step 4: Zelensky will be forced to leave Ukraine.

@ShadowofEzra

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Shadow of Ezra 13.12.2023 16:41:58

All eyes should be on Clarence Thomas.

@ShadowofEzra

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Kayleigh McEnany 12.12.2023 15:01:53

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https://t.me/+WijoiuEYEyRhMzJh

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Natural Remedies 🥦 12.12.2023 13:50:01

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🚨 Alert, ladies! Think twice before reaching for your Folic Acid supplement! 🚨

🌿As your trusted health ally with years of expertise in Holistic health, I aim to debunk health myths and misconceptions that could affect you.

Many believe that vitamins equate to better health. While this is true to some extent, but supplements that are isolated are always synthetic.

Folic Acid is one of them!

📚Evidence-based advice :

– Numerous studies suggest a strong correlation between excessive intake of Folic Acid and heightened risk of certain health conditions, emphasizing the need for moderation.

💊Use Guidelines :

– Unless specifically recommended by a healthcare professional, skip the Folic Acid supplement and look to fulfill your requirement naturally through your diet.

⚠️Risks & Precautions :

– Be cautious of the potential risks associated with overconsuming Folic Acid supplements.

Subscribe: Natural Remedies

18:24

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X22 Report Official 09.12.2023 15:53:04

https://rumble.com/v40ftts-bitcoin-ben-the-future-is-the-blockchain-bitcoin-going-to-100000-cb-cannot-.html?mref=2hzb1&mc=fcbfy

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Disclose.tv 11.12.2023 17:03:21

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NEW - China's cyber army is invading critical U.S. services, including the power grid, ports, pipelines, water utilities.

@disclosetv

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X22 Report Official 11.12.2023 17:21:05

Right on schedule

With the dramatic rise in antisemitism, we are discovering that this is a mistake: Antisemitism — and other forms of hate — cannot be fought on university campuses without restricting poisonous speech that targets Jews and other minorities.

https://www.washingtonpost.com/opinions/2023/12/10/university-pennsylvania-president-magill-resigns-antisemitism-speech/

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il Donaldo Trumpo 10.12.2023 18:52:30

GOD IS GOOD!!!

18:26

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il Donaldo Trumpo 10.12.2023 19:15:52

CONGRATULATIONS, MI JAVI!!! THE LIONS ARE AWAKE!!!🥳🥳🥳

https://rumble.com/v40m4yw-vamos.html

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il Donaldo Trumpo 10.12.2023 22:39:56

LATER, LOSERS!!!😎🥳🥳🥳#NotGoingBack

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il Donaldo Trumpo 10.12.2023 23:04:34

OMG!!! #PissGate IS REAL!!!😭🤣🤣🤣

https://rumble.com/v40n3wu-pissgate.html

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il Donaldo Trumpo 10.12.2023 00:19:20

EVEN WITH THE YOUNG PATRIOTS!!!🇺🇸🥳🥳🥳#WINNING

https://rumble.com/v40i4ft-winning.html

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il Donaldo Trumpo 11.12.2023 00:03:57

BEST TIME OF THE YEAR!!!🎄🥳🥳🥳

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il Donaldo Trumpo 11.12.2023 01:18:56

THE PEOPLE'S PRESIDENT!!!❤️🇺🇸

https://rumble.com/v40nlnb-realove.html

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il Donaldo Trumpo 11.12.2023 21:10:09

THE REAL COMMANDER IN CHIEF!!!🇺🇸

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il Donaldo Trumpo 12.12.2023 00:30:33

WAIT FOR IT...🤣🤣🤣

https://rumble.com/v40s9op-fpm.html

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il Donaldo Trumpo 12.12.2023 04:25:48

WHO DID THIS???😭🤣🤣🤣

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Concerned Lawyers Network 08.12.2023 07:29:41

https://www.zerohedge.com/geopolitical/rothschild-wants-merger-between-corporations-governments-ai-save-capitalism

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Concerned Lawyers Network 08.12.2023 07:30:34

https://kirschsubstack.com/p/data-from-us-medicare-and-the-new

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COUNTERSPIN MEDIA (OFFICIAL) 03.12.2023 06:10:59

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BREAKING

Police swarm whistleblower and associates homes this afternoon obviously in relation to the information that was released to stop further harm and death by the Covid shots.

If this information was flawed why are the police involved instead of it being treated as an employment matter.

We have spoken to Liz who at this time is safe and she is heading to an undisclosed location.

Spread this information far and wide.

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ONPASSIVE JohnnyB 03.12.2023 09:43:20

🚨🚨🚨WORLDWIDE ALERT!!!🚨🚨🚨

New Zealand Journalist Liz Gunn releases an official statement advising the NZ Ministry of Health Whistleblower and person working with him have both been raided by police.

Liz Gunn reports police are still surrounding the Whistleblowers’ home after several hours following the raid.

Gunn calls for the New Zealand government to call off this tyrannical response and give the Whistleblower the honour and respect he deserves as a national hero.

Please share this video everywhere for the sake of the safety of all involved in bringing this crucial COVID injection data to the world!

https://zeeemedia.com/interview/emergency-update-nz-whistleblower-raided-by-police/?fbclid=IwAR1OkI4tALEYNYmKfToSkXaXsNZdGmJMItg0FgufvevTY-rSq6GjqPnH01o

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Zeee Media 🎙 08.12.2023 08:29:32

If you missed it👇

Alex Jones’ interview with NZ Whistleblower Barry Young:

https://banned.video/watch?id=656f94b10681e680640f045f

Alex Jones’ interview with Liz Gunn:

https://banned.video/watch?id=656fb3000681e680641328ab

My interview with Hannah Spierer from Counterspin:

https://banned.video/watch?id=656fb4650681e680641365d0

Follow @zeeemedia

Website | X | Instagram | Rumble

18:30

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Zeee Media 🎙 08.12.2023 08:29:32

18:30

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Zeee Media 🎙 08.12.2023 08:29:32

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Zeee Media 🎙 08.12.2023 08:28:35

Lol. The establishment is upset because Barry Young didn’t violate his bail conditions by interviewing with Alex.

He’s done nothing wrong… at all.

https://www.nzherald.co.nz/nz/conspiracy-theorist-alex-jones-interviews-te-whatu-ora-staffer-barry-young-charged-over-covid-19-data-leak/5QJQBY6KCFBI3KEU5LIWPTCNWE/

Follow @zeeemedia

Website | X | Instagram | Rumble

18:31

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Concerned Lawyers Network 12.12.2023 02:31:16

https://bailiwicknews.substack.com/p/legal-walls-short-version?utm_campaign=post_embed

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Dr Jane Ruby 09.12.2023 15:50:54

I've always operated on the premise that all of these platforms like Telegram, Signal, TikTok etc. were owned and run by the CIA.

Many of you shout out, "oh they're owned by Russia, or China, etc." but in the end all roads lead back to the same place

Those of us on the front lines are not stupid, but we plow forward because we're using whatever we can until they no longer exist.

Plan, prep, pray

https://kitklarenberg.substack.com/p/signal-facing-collapse-after-cia

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Dr Jane Ruby 09.12.2023 19:44:58

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After hospitals with their freedom to murder with impunity…schools are the next most deadly places

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Dr Jane Ruby 09.12.2023 19:45:05

☕️🇺🇸☕️🇺🇸☕️♥️☕️♥️☕️🇺🇸☕️

COFFEE CHAT WITH DR. JANE

COMPROMISED LEADERS AND DISSONANCE ARE TOOLS OF WAR

https://rumble.com/v40gnwy-compromise-and-dissonance-are-tools-of-war.html

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Dr Jane Ruby 11.12.2023 15:24:15

TRUTH: @piersmorgan has a damaged immune system from multiple Bioweapon shots that he believed were vaccines

Just like the pre-clinical study animals who were injected and then died two weeks later when exposed in the wild, his immune system is exhausted from fighting synthetic antigens on the INSIDE (self made billions of spike proteins), so it cannot defend him from opportunistic organisms on the OUTSIDE.

View & subscribe to my work on GMOs, the Bioweapons, & The Great Reset at Rumble.com/c/drjaneruby

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Dr Jane Ruby 11.12.2023 22:06:24

Much appreciation and congratulations to @Bitmanlawfirm ON WIN #3

My Atty Ronnie Bitman Hit it out of the park TODAY in the Federal District Court DISMISSAL of MALONE V RUBY

BYE @RWMaloneMD #lawfare loser

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Dr Jane Ruby 12.12.2023 16:05:38

STATEMENT BY DR JANE RUBY: FREE SPEECH LIVES!

DR. JANE RUBY OFFICIAL STATEMENT

@rwmalonemd

https://rumble.com/v40vnxe-statement-by-dr.-jane-ruby-free-speech-lives.html

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Prophecies Fulfilled 08.12.2023 04:13:34

A SHAKE-UP IS COMING TO THE GOVERNMENT OF THE UNITED STATES

Word Received: December 28, 2022

Something big is brewing in Texas that is about to be revealed.

December 7, 2023

https://thepostmillennial.com/federal-appeals-court-orders-texas-to-remove-razor-wire-border-barriers-from-rio-grande-greg-abbott-promises-to-take-it-to-the-supreme-court?utm_campaign=64483

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Prophecies Fulfilled 08.12.2023 05:56:54

A GREAT DISMANTLING OF THEIR POWER IN THIS COUNTRY HAS BEGUN

Word Received: August 10, 2023

The WHO is about to be exposed big time, and nothing can stop the collapse of this organization.

IT'S TIME TO TEAR THE ONE WORLD GOVERNMENT APART

Word Received: December 31, 2022

The WHO is being exposed. News reports, one right after another, will reveal the truth about all they have been hiding, who controls them, and who has been financing their plans. It's all coming out, so get ready. 

December 6, 2023

vigilantnews.com/post/slovakia-shocks-the-world-new-prime-minister-rejects-signing-the-who-pandemic-treaty

Prime Minister Robert Fico calls the WHO Pandemic Treaty "nonsense invented by greedy pharma companies."

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Prophecies Fulfilled 08.12.2023 06:26:32

👀 PROPHECY IN PROGRESS 👀

I AM SHAKING THIS EARTH TO SHAKE THE CAPTIVES FREE

Word Received: April 1, 2022

The United Nations, I have told you before, I am exposing you, opening up your books, exposing your bank accounts, and showing the world your name is a lie. You wanted to decimate freedom and liberty to cause division on a scale on this Earth never known before. I am ripping your plans to shreds and destroying everything you stand for. United Nations, you will have nothing left as I move My hand against you. You are so desperately trying to destroy evidence, but it's too late. I have it all, and I have had it since your beginning.

I will be your end, United Nations, for I, the Lord, am against you. You will see I was in charge all along, and you played right into My hand. The walls are closing in, and you don't know what to do. Well, you can't do anything. There is nowhere to run, nowhere to hide. This is your time to end, United Nations.

December 5, 2023 PRAY

https://t.me/businessoftruth/40254

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Prophecies Fulfilled 08.12.2023 18:05:53

👀 PROPHECIES IN PROGRESS 👀

THEIR HOUSE OF CARDS IS COMING DOWN

Date Word Received: Sept 29, 2022

Biblical: this word will be continuously in your news showing how things are extreme and unusual. Biblical will be the word they use to describe what you see, saith the Lord.

NATIONS WILL COLLAPSE IN A DAY 

Date Word Received: February 3, 2023

Locusts will be in your news for a significant reason. 

💎Thanks to James Burns for sharing this information in the chat. 💎

Locusts swarm Mexico region in biblical proportions: ‘I won’t open my mouth again!’

December 7, 2023

Links:

https://nypost.com/2023/12/07/lifestyle/locusts-swarm-mexico-region-in-biblical-proportions/amp/

https://youtu.be/FamsbyYC7XA?si=0NsWATujrw4N_2tJ

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Prophecies Fulfilled 08.12.2023 23:48:13

👀 PROPHECY IN PROGRESS 👀

MY MIGHTY WORKS WILL BE SEEN BY THE WORLD

Word Received: June 6, 2022

This company Google: I am coming for you. You can't hide from the destruction that is about to plague your company. You thought you had the power to take My mouthpieces down with no consequences. You will soon find out every secret you thought was safe wasn't. I have it all and so do the ones with Me that I have let them have and see this information. Google, your stocks will plummet. Your power will be stripped from every one of you like you never existed. Your company will be handed over to My children, saith the Lord.

December 8, 2023

https://twitter.com/thechiefnerd/status/1733212456778965145

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Trump Office 12.12.2023 18:31:00

Get ready, Iowa! President Trump will be speaking in Coralville on Wednesday night.

Tune into RSBN at 5 pm ET!

https://www.rsbnetwork.com/video/live-president-trump-rallies-voters-at-commit-to-caucus-event-in-coralville-iowa/

Join the Trump Office Telegram channel

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21:57

World News

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LauraAboli 12.12.2023 12:00:00

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😁😁😁

https://t.me/LauraAbolichannel

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22:32

World News

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LauraAboli 12.12.2023 12:06:26

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The prisoners are waking up! This is the Great Awakening…

https://t.me/LauraAbolichannel

KM

23:04

Kathy R Meems 🇺🇸🍿

Biden and Zelensky are holding a joint news conference begging for more money and arms for Ukraine

#FJB

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23:42

World News

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 WW3 Digital Soldiers 🌍

Previous messages

12 December 2023

15:47

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Edward Snowden 12.12.2023 15:43:01

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Albert Pike died in 1891. He predicted 3 world wars.

Join: John F. Kennedy Jr. ⚡️

18:00

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Trump Office 12.12.2023 17:31:09

Over the past week, Donald Trump promised to be a “dictator” on two different occasions. Sadly, that’s not a completely unexpected sentence to write given that he and his allies haven’t been shy about planning an authoritarian second term, from installing MAGA loyalists throughout the government to using the Department of Justice to target political enemies.

https://www.vanityfair.com/news/donald-trumps-dictator-promise-is-no-joke

Wow! They scared! 😂

Join the Trump Office Telegram channel

18:06

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Trump Office 12.12.2023 17:33:30

Join the Trump Office Telegram channel

18:06

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Nesara Gesara-Secrets 12.12.2023 15:45:20

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As part of the 'C40 Cities' initiative—which has ties to the World Economic Forum—mayors in almost 100 cities around the world have set themselves the "ambitious target" of zero meat or dairy consumption, and zero private vehicles by 2030, "to save the planet".

Subscribe: NESARA GESARA-SECRETS ✅ Private

18:06

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Conspiracy Theory 09.12.2023 00:00:00

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Lululemon leggings contain chemicals that are difficult for the human body to get rid of. They’re called “forever chemicals” for a reason.

And they’re associated with hormone disruption, cancers, and others. Opt for natural fabrics like cotton or wool.

Follow Us -> Conspiracy Theory👤

18:06

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The General 12.12.2023 13:58:32

BREAKING: Rep. Tim Burchett has requested the Chairman on House GOP Oversight Committee, James Comer to subpoena Epstein's flight logs.

@GeneralMCNews

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The General 12.12.2023 15:49:57

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WATCH: Italian Health Minister gave orders to conceal vaccination deaths.

Now under investigation for murder.

@GeneralMCNews

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The General 12.12.2023 17:09:57

BREAKING: The Department of Defense is conducting military training operations at several sites in North Texas through this week. The training will involve air and ground mobility across the metroplex.

@GeneralMCNews

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SantaSurfing 12.12.2023 17:03:12

Speaker Johnson pushing for impeachment

"Evidence against Biden can't be ignored"🙏🙏

https://www.usatoday.com/story/opinion/2023/12/12/biden-impeachment-inquiry-vote-house-republicans-speaker-mike-johnson/71877294007/

Follow: @SantaSurfing

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President Q45 12.12.2023 16:08:39

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— THE HUMAN MEAT PROJECT — NQTING TQ SEE HERE 👀 —

Join : President Trump Warns 🔴

18:06

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White Hats 12.12.2023 15:24:01

Get it Yet!?

Join: John F. Kennedy Jr. ⚡️

18:07

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We The People 07.12.2023 17:35:06

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HERBS TO ELIMINATE PARASITES!

SHARE MUCH MORE IS COMING!!

JOIN: Mr.Pool

18:11

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Benny Johnson 11.12.2023 22:31:31

Tucker Carlson officially launches ‘Tucker Carlson Network’ at http://TuckerCarlson.com

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Jeffrey Peterson - jeff.pro 11.12.2023 23:49:04

Well, I guess from here on, this guy needs to find a new job.

Where will he go next?

CNN? Pfizer?

Maybe he can be "speaker" in Ukraine?

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WikiLeaks Organisation ️ 20.11.2023 00:55:01

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The most notorious document in the history of the United States.

Dr. David Ayoub MD explains how the medical establishment through certified documentation is working hand in hand with the global cabal to facilitate the depopulation agenda.

Follow  👉 WikiLeaksOrganisation for more information ✅️

18:12

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And We Know® 12.12.2023 18:07:46

12.12.23: LT w/ Cristin Ludlow & Baby Trump: Mushrooms saving lives? Powerful! Pray!

Watch on Rumble: http://tinyurl.com/4ny29mes

➤ https://andweknow.com

➤ https://thepatriotlight.com

18:14

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The KINGDOM ORACLE 🔥 12.12.2023 12:53:44

LIVE WITH JULIE GREEN DEC 11TH 2023

WATCH

https://rumble.com/v40uv64-live-with-julie.html

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JULIE GREEN MINISTRIES:

TODAY’S SCRIPTURES:

1. Gen. 11:1-9 Tower of Babel

2. Isa. 54:17

3. Isa. 53:5; 1 Peter 2:24 (Christ’s stripes)

4. Luke 10:19

5. Deut. 28:13 (Head not the tail, above not the beneath)

6. 2 Cor 2:14 (God always causes you to triumph)

7. Rom. 5:1 (made righteous through Christ)

8. Neh. 8:10 (Joy of the Lord)

9. Dan. 10:10-13

10. Ps. 34:17-19

11. Ps. 34 (entire chapter)

12. Matt. 16:19, 18:18 (binding and rebuking)

13. Num. 23:19 (God is not a man he should lie)

14. Isa. 55:11 (His Words do not return to Him void)

15. Phil. 2:9-11 (Every knee must bow)

16. 1 John 5:14-15

17. Deut. 30:19 (Choice between life and death, blessing and curse)

18. Jer. 1:12; Heb. 10:23 (God is faithful to perform His Word)

19. Dan. 3 (Shadrach, Meshach, Abednego)

20. Dan. 6:14-22

21. 2 Kings 6:16-17

22. 2 Cor. 5:7 (walk by faith, not by sight)

23. 2 Kings 7:1-10, 16, 19-20

24. Rom. 8:31 (If god be for you, who can be against you)

25. Deut 28:7

26. Deut. 31:8; Josh 1:5 (never leave you nor forsake you)

27. 1 Cor. 2:9

God is making America great again! He is the One making it great, and no man or enemy of God can stop God.

Watch the teaching by Jerry Savelle: If Satan can’t steal your joy, then he can’t keep your goods (https://www.youtube.com/watch?v=28DmyCSrET8)

God always answers prayer so long as your prayers are in alignment with His Word

Declare: The Works of God’s hands are working mightily on my behalf. I am free! I do not fear!

Marching Order May 19, 2023

God says: Awake in a greater revelation of who I am and stay the course...

I declare in Jesus’ name: These are the days of great miracles, revivals, revelation, restitution, and vindication.

Read more here: https://www.jgminternational.org/blog/what-to-do-about-the-chaos-around-you 

Copyright © 2023 Julie Green Ministries International

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Follow 🕊 t.me/KingdomJubileeMedia

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Trump Office 12.12.2023 17:48:06

Join the Trump Office Telegram channel

18:14

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We The People 12.12.2023 15:31:01

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👺 THE DECEPTION BEHIND THE TITANIC ......and The Men Who Opposed the Federal Reserve....

Join: John F. Kennedy Jr. ⚡️

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Dan Scavino 12.12.2023 15:25:14

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Kash Patel triples down on arresting anyone in the media who broke the law in a conspiracy to rig an election and says we caught them all and that's why they are panicking:

"They are afraid that President Trump is going to come in and actually use the law to prosecute those who broke it. Whether they are in government, private sector, civilians, and yes, even if they are in the media if they participated in a conspiracy to rig elections and break the law you will be prosecuted..

The entire quote says we will use the constitutional courts of law to go after those that broke the law including those in the media.

I think they are threatened because we caught them in Russia Gate, we caught them with 51 intel letter, we caught them on Jan 6th, we are catching them in Hunter Biden/Joe Biden criminal activities, and American citizens are tired of it. And they know they are in on it. That's when criminals fret the most and that's why are they slinging baseless rhetoric and hyperbole."

It's what we all want to see. Justice 2024.

Let's go anons.

Join: John F. Kennedy Jr. ⚡️

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Ezra A. Cohen 09.12.2023 21:23:01

Mainstream media is now officially linking Mark Zuckerberg to child sex trafficking.

Do you understand the significance of this for the Great Awakening process?

Lawsuits are highly effective. Expect more to come.

Join: John F. Kennedy Jr. ⚡️

18:17

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Ezra A. Cohen 10.12.2023 15:21:01

How would you react if The Rock and Oprah ran as President and Vice President for the 2024 elections?

Join: John F. Kennedy Jr. ⚡️

18:17

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Ezra A. Cohen 10.12.2023 21:16:01

Vivek Ramaswamy is the Republican Barack Obama.

Many have already been fooled.

Who is Vivek a puppet to?

The country that is left for last.

The masters of deception.

Join: John F. Kennedy Jr. ⚡️

18:18

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Ezra A. Cohen 12.12.2023 15:17:01

The Obama False Flag.

Trump has been warning.

Join: John F. Kennedy Jr. ⚡️

18:19

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ABSTRACT

BACKGROUND: Filgotinib (FIL) is a selective JAK1 inhibitor with an affinity 30-fold higher than JAK2, approved to treat moderate to severe active rheumatoid arthritis (RA), in adults with inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs).

METHODS: We conducted a retrospective, multicentric study in order to evaluate efficacy and safety of FIL 200 mg daily therapy, after 3 and 6 months, in 120 patients affected by RA, managed in Tuscany and Umbria rheumatological centers. The following clinical records were analyzed: demographical data, smoking status, previous presence of comorbidities (Herpes zoster -HZ- infection, venous thromboembolism -VTE-, major adverse cardiovascular events -MACE-, cancer, diabetes, and hypertension), disease duration, presence of anti-citrullinated protein antibodies (ACPA), rheumatoid factor (RF), number of biological failures, and prior csDMARDs utilized. At baseline, and after 3 (T3) and 6 (T6) months of FIL therapy, we evaluated mean steroid dosage, csDMARDs intake, clinimetric indexes (DAS28, CDAI, HAQ, patient and doctor PGA, VAS), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and body mass index (BMI).

RESULTS: At baseline, the mean disease duration was 9.4 ± 7.5 years; the prevalence of previous HZ infection, VTE, MACE, and cancer was respectively 4.12%, 0%, 7.21%, and 0.83%, respectively. In total, 76.3% of patients failed one or more biologics (one biological failure, 20.6%; two biological failures, 27.8%; three biological failures, 16.5%; four biological failures, 10.3%; five biological failures, 1.1%). After 3 months of FIL therapy, all clinimetric index results significantly improved from baseline, as well as after 6 months. Also, ESR and CRP significatively decreased at T3 and T6. Two cases of HZ were recorded, while no new MACE, VTE, or cancer were recorded during the observation time.

CONCLUSION: Despite the limitations of the retrospective study and of the observational period of only 6 months, real-life data on the treatment of RA patients with FIL demonstrate that this Jak inhibitor therapy is safe in terms of CV, VTE events, and occurrence of cancer, and is also effective in a population identified as "difficult to treat" due to failure of previous b-DMARD therapy.

PMID:37763071 | PMC:PMC10532886 | DOI:10.3390/jpm13091303

Next messages

 

ABSTRACT

BACKGROUND: Venous thromboembolism (VTE) is a leading cause of preventable mortality among hospitalized patients, but appropriate risk assessment and thromboprophylaxis remain underutilized or misapplied.

OBJECTIVES: We conducted an electronic survey of US health care providers to explore attitudes, practices, and barriers related to thromboprophylaxis in adult hospitalized patients and at discharge.

RESULTS: A total of 607 US respondents completed the survey: 63.1% reported working in an academic hospital, 70.7% identified as physicians, and hospital medicine was the most frequent specialty (52.1%). The majority of respondents agreed that VTE prophylaxis is important (98.8%; 95% CI: 97.6%-99.5%) and that current measures are safe (92.6%; 95% CI: 90.2%-94.5%) and effective (93.8%; 95% CI: 91.6%-95.6%), but only half (52.0%; 95% CI: 47.9%-56.0%) believed that hospitalized patients at their institution are on appropriate VTE prophylaxis almost all the time. One-third (35.4%) reported using a risk assessment model (RAM) to determine VTE prophylaxis need; 44.9% reported unfamiliarity with RAMs. The most common recommendation for improving rates of appropriate thromboprophylaxis was to leverage technology. A majority of respondents (84.5%) do not reassess a patient's need for VTE prophylaxis at discharge, and a minority educates patients about the risk (16.2%) or symptoms (18.9%) of VTE at discharge.

CONCLUSION: Despite guideline recommendations to use RAMs, the majority of providers in our survey do not use them. A majority of respondents believed that technology could help improve VTE prophylaxis rates. A majority of respondents do not reassess the risk of VTE at discharge or educate patients about this risk of VTE at discharge.

PMID:37767063 | PMC:PMC10520566 | DOI:10.1016/j.rpth.2023.102168

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PubMed articles on: Cardio-Oncology

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades

Int J Mol Sci. 2023 Sep 13;24(18):14013. doi: 10.3390/ijms241814013.

ABSTRACT

Cancer chemotherapy with doxorubicin (DOX) may have multiorgan toxicities including cardiotoxicity, and this is one of the major limitations of its clinical use. The present study aimed to evaluate the cardioprotective role of α-Bisabolol (BSB) in DOX-induced acute cardiotoxicity in rats and the underlying pharmacological and molecular mechanisms. DOX (12.5 mg/kg, single dose) was injected intraperitoneally into the rats for induction of acute cardiotoxicity. BSB was given orally to rats (25 mg/kg, p.o. twice daily) for a duration of five days. DOX administration induced cardiac dysfunction as evidenced by altered body weight, hemodynamics, and release of cardio-specific diagnostic markers. The occurrence of oxidative stress was evidenced by a significant decline in antioxidant defense along with a rise in lipid peroxidation and hyperlipidemia. Additionally, DOX also increased the levels and expression of proinflammatory cytokines and inflammatory mediators, as well as activated NF-κB/MAPK signaling in the heart, following alterations in the Nrf2/Keap-1/HO-1 and Akt/mTOR/GSK-3β signaling. DOX also perturbed NLRP3 inflammasome activation-mediated pyroptosis in the myocardium of rats. Furthermore, histopathological studies revealed cellular alterations in the myocardium. On the contrary, treatment with BSB has been observed to preserve the myocardium and restore all the cellular, molecular, and structural perturbations in the heart tissues of DOX-induced cardiotoxicity in rats. Results of the present study clearly demonstrate the protective role of BSB against DOX-induced cardiotoxicity, which is attributed to its potent antioxidant, anti-inflammatory, and antihyperlipidemic effects resulting from favorable modulation of numerous cellular signaling regulatory pathways, viz., Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 inflammasomes, in countering the cascades of oxidative stress and inflammation. The observations suggest that BSB can be a promising agent or an adjuvant to limit the cardiac injury caused by DOX. Further studies including the role in tumor-bearing animals as well as regulatory toxicology are suggested.

PMID:37762315 | PMC:PMC10530367 | DOI:10.3390/ijms241814013

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PubMed articles on: Cancer & VTE/PE

Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

Life (Basel). 2023 Sep 10;13(9):1888. doi: 10.3390/life13091888.

ABSTRACT

Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs).

PMID:37763292 | PMC:PMC10532829 | DOI:10.3390/life13091888

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PubMed articles on: Cardio-Oncology

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Int J Mol Sci. 2023 Sep 7;24(18):13826. doi: 10.3390/ijms241813826.

ABSTRACT

The identification of novel drug targets is needed to improve the outcomes of heart failure (HF). G-protein-coupled receptors (GPCRs) represent the largest family of targets for already approved drugs, thus providing an opportunity for drug repurposing. Here, we aimed (i) to investigate the differential expressions of 288 cardiac GPCRs via droplet digital PCR (ddPCR) and bulk RNA sequencing (RNAseq) in a rat model of left ventricular pressure-overload; (ii) to compare RNAseq findings with those of ddPCR; and (iii) to screen and test for novel, translatable GPCR drug targets in HF. Male Wistar rats subjected to transverse aortic constriction (TAC, n = 5) showed significant systolic dysfunction vs. sham operated animals (SHAM, n = 5) via echocardiography. In TAC vs. SHAM hearts, RNAseq identified 69, and ddPCR identified 27 significantly differentially expressed GPCR mRNAs, 8 of which were identified using both methods, thus showing a correlation between the two methods. Of these, Prostaglandin-F2α-receptor (Ptgfr) was further investigated and localized on cardiomyocytes and fibroblasts in murine hearts via RNA-Scope. Antagonizing Ptgfr via AL-8810 reverted angiotensin-II-induced cardiomyocyte hypertrophy in vitro. In conclusion, using ddPCR as a novel screening method, we were able to identify GPCR targets in HF. We also show that the antagonism of Ptgfr could be a novel target in HF by alleviating cardiomyocyte hypertrophy.

PMID:37762130 | PMC:PMC10531061 | DOI:10.3390/ijms241813826

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PubMed articles on: Cancer & VTE/PE

The Risk of Thromboembolism in Patients with Muscle Invasive Bladder Cancer before and after Cystectomy Depending on Blood Group and Neoadjuvant Chemotherapy-A Multicentre Retrospective Cohort Study

J Pers Med. 2023 Sep 4;13(9):1355. doi: 10.3390/jpm13091355.

ABSTRACT

PURPOSE: Previous studies have indicated that patients with muscle-invasive bladder cancer with non-O blood types have an increased risk of experiencing thromboembolic events (TEEs). This is finding is in relation to neoadjuvant-chemotherapy (NAC)-naïve patients.

AIM: to establish the risk of TEEs and any association with blood types among NAC patients as well as NAC-naïve patients.

METHODS: Cystectomized patients at four centres treated from 2009 to 2018 (n = 244) were analysed. The quantities of patients corresponding to each blood group were as follows: A-108 (44%); O-99 (41%); B-30 (12%); and AB-7 (3%). NAC patients (n = 167) and NAC-naïve NAC-eligible patients (n = 77) were assessed. In total, 54 women (22%) and 190 men (78%), with a median age of 69 years, were included in the study. The occurrence of any type of TEE from six months pre-cystectomy to 12-24 months after was analysed using logistic regression adjusted for NAC and confounders.

RESULTS: Sixty-six TEEs were detected in 21% of the patients (n = 52). Pulmonary embolus (n = 33) and deep venous thrombosis (n = 11) were the most common forms. No significant differences between blood types were found in the analysis, although B blood type had a nearly significant increased crude risk compared with O blood type, for which there was an OR of 2.48 (95% CI 0.98-6.36). Adjustment for NAC and covariates weakened the OR, which plummeted to 1.98 (95% CI 0.71-5.51).

CONCLUSIONS: No significant associations were found between blood types and TEE occurrences in this cohort including both NAC and NAC-naïve NAC-eligible patients.

PMID:37763123 | PMC:PMC10533159 | DOI:10.3390/jpm13091355

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PubMed articles on: Cardio-Oncology

Social Determinants of Health Data Improve the Prediction of Cardiac Outcomes in Females with Breast Cancer

Cancers (Basel). 2023 Sep 19;15(18):4630. doi: 10.3390/cancers15184630.

ABSTRACT

Cardiovascular disease is the leading cause of mortality among breast cancer (BC) patients aged 50 and above. Machine Learning (ML) models are increasingly utilized as prediction tools, and recent evidence suggests that incorporating social determinants of health (SDOH) data can enhance its performance. This study included females ≥ 18 years diagnosed with BC at any stage. The outcomes were the diagnosis and time-to-event of major adverse cardiovascular events (MACEs) within two years following a cancer diagnosis. Covariates encompassed demographics, risk factors, individual and neighborhood-level SDOH, tumor characteristics, and BC treatment. Race-specific and race-agnostic Extreme Gradient Boosting ML models with and without SDOH data were developed and compared based on their C-index. Among 4309 patients, 11.4% experienced a 2-year MACE. The race-agnostic models exhibited a C-index of 0.78 (95% CI 0.76-0.79) and 0.81 (95% CI 0.80-0.82) without and with SDOH data, respectively. In non-Hispanic Black women (NHB; n = 765), models without and with SDOH data achieved a C-index of 0.74 (95% CI 0.72-0.76) and 0.75 (95% CI 0.73-0.78), respectively. Among non-Hispanic White women (n = 3321), models without and with SDOH data yielded a C-index of 0.79 (95% CI 0.77-0.80) and 0.79 (95% CI 0.77-0.80), respectively. In summary, including SDOH data improves the predictive performance of ML models in forecasting 2-year MACE among BC females, particularly within NHB.

PMID:37760599 | PMC:PMC10526347 | DOI:10.3390/cancers15184630

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PubMed articles on: Cancer & VTE/PE

ReLiFiRa (Real Life Filgotinib in Rheumatoid Arthritis): Retrospective Study of Efficacy and Safety in Common Clinical Practice

J Pers Med. 2023 Aug 25;13(9):1303. doi: 10.3390/jpm13091303.

 

ABSTRACT

BACKGROUND: Emulating randomized controlled trials (RCTs) by real-world evidence (RWE) studies would benefit future clinical and regulatory decision-making by balancing the limitations of RCT. We aimed to evaluate whether the findings from RWE studies can support regulatory decisions derived from RCTs of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with venous thromboembolism (VTE).

METHODS: Five landmark trials (AMPLIFY, RE-COVER II, Hokusai-VTE, EINSTEIN-DVT, and EINSTEIN-PE) of NOACs were emulated using the South Korean nationwide claims database (January 2012 to August 2020). We applied an active comparator and new-user design to include patients who initiated oral anticoagulants within 28 days from their VTE diagnoses. The prespecified eligibility criteria, exposure (each NOAC, such as apixaban, rivaroxaban, dabigatran, and edoxaban), comparator (conventional therapy, defined as subcutaneous heparin followed by warfarin), and the definition of outcomes from RCTs were emulated as closely as possible in each separate emulation cohort. The primary outcome was identical to each trial, which was defined as recurrent VTE or VTE-related death. The safety outcome was major bleeding. Propensity score matching was conducted to balance 69 covariates between the exposure groups. Effect estimates for outcomes were estimated using the Mantel-Haenszel method and Cox proportional hazards model and subsequently compared with the corresponding RCT estimates.

RESULTS: Compared to trial populations, real-world study populations were older (range: 63-69 years [RWE] vs. 54-59 years [RCT]), with more females (55-60.5% vs. 39-48.3%) and had a higher prevalence of active cancer (4.2-15.4% vs. 2.5-9.5%). The emulated estimates for effectiveness outcomes showed superior effectiveness of NOAC (AMPLIFY: relative risk 0.81, 95% confidence interval 0.70-0.94; RE-COVER II: hazard ratio [HR] 0.60, 0.37-0.96; Hokusai-VTE: 0.49, 0.31-0.78; EINSTEIN-DVT: 0.54, 0.33-0.89; EINSTEIN-PE: 0.50, 0.34-0.74), when contrasted with trials that showed non-inferiority. For safety outcomes, all emulations except for AMPLIFY and EINSTEIN-DVT yielded results consistent with their corresponding RCTs.

CONCLUSIONS: This study revealed the feasibility of complementing RCTs with RWE studies by using claims data in patients with VTE. Future studies to consider the different demographic characteristics between RCT and RWE populations are needed.

PMID:37775786 | PMC:PMC10542685 | DOI:10.1186/s12916-023-03069-1

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PubMed articles on: Cardio-Oncology

Hyperhomocysteinaemia Promotes Doxorubicin-Induced Cardiotoxicity in Mice

Pharmaceuticals (Basel). 2023 Aug 28;16(9):1212. doi: 10.3390/ph16091212.

ABSTRACT

Doxorubicin, a widely used chemotherapeutic drug in clinical oncology, causes a series of cardiac side effects referred to as doxorubicin-induced cardiotoxicity. Hyperhomocysteinaemia is an independent risk factor for multiple cardiovascular diseases. However, whether hyperhomocysteinaemia contributes to doxorubicin-induced cardiotoxicity is currently unknown. In this study, we explored the pathogenic effects of hyperhomocysteinaemia induced by dietary methionine supplementation (2% wt/wt in rodent chow) in a mouse model of doxorubicin-induced cardiotoxicity. Our data showed that methionine supplementation doubled serum homocysteine levels, inducing mild hyperhomocysteinaemia. Doxorubicin at a cumulative dosage of 25 mg/kg body weight led to significant weight loss and severe cardiac dysfunction, which were further exacerbated by methionine-induced mild hyperhomocysteinaemia. Doxorubicin-induced cardiac atrophy, cytoplasmic vacuolisation, myofibrillar disarray and loss, as well as cardiac fibrosis, were also exacerbated by methionine-induced mild hyperhomocysteinaemia. Additional folic acid supplementation (0.006% wt/wt) prevented methionine-induced hyperhomocysteinaemia and inhibited hyperhomocysteinaemia-aggravated cardiac dysfunction and cardiomyopathy. In particular, hyperhomocysteinaemia increased both serum and cardiac oxidative stress, which could all be inhibited by folic acid supplementation. Therefore, we demonstrated for the first time that hyperhomocysteinaemia could exacerbate doxorubicin-induced cardiotoxicity in mice, and the pathogenic effects of hyperhomocysteinaemia might at least partially correlate with increased oxidative stress and could be prevented by folic acid supplementation. Our study provides preliminary experimental evidence for the assessment of hyperhomocysteinaemia as a potential risk factor for chemotherapy-induced cardiotoxicity in cancer patients.

PMID:37765020 | PMC:PMC10534320 | DOI:10.3390/ph16091212

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PubMed articles on: Cancer & VTE/PE

A case report: A patient rescued by VA-ECMO after cardiac arrest triggered by trigeminocardiac reflex after nasal surgery

Medicine (Baltimore). 2023 Sep 29;102(39):e35226. doi: 10.1097/MD.0000000000035226.

ABSTRACT

RATIONALE: Cardiac arrest (CA) caused by trigeminocardiac reflex (TCR) after endoscopic nasal surgery is rare. Hence, when a patient suffers from TCR induced CA in the recovery room, most doctors may not be able to find the cause in a short time, and standard cardiopulmonary resuscitation and resuscitation measures may not be effective. Providing circulatory assistance through venous-arterial extracorporeal membrane oxygenation (VA-ECMO) can help healthcare providers gain time to identify the etiology and initiate symptom-specific treatment.

PATIENT CONCERNS: We report a rare case of CA after endoscopic nasal surgery treated with VA-ECMO.

DIAGNOSES: We excluded myocardial infarction, pulmonary embolism, allergies, hypoxia, and electrolyte abnormalities based on the relevant examination results. Following a multidisciplinary consultation, clinical manifestation and a review of previous literature, we reasoned that the CA was due to TCR.

INTERVENTIONS: VA-ECMO was established to resuscitate the patient successfully during effective cardiopulmonary resuscitation.

OUTCOMES: ECMO was successfully evacuated a period of 190 minutes of therapy. The patient was discharged home on day 8.

LESSONS: TCR is notable during endoscopic nasal surgery. Our case indicates that CA in operating room is worth prolonged CCPR. The ideal time for ECPR implementation should not be limited within 20 minutes after CCPR.

PMID:37773828 | PMC:PMC10545381 | DOI:10.1097/MD.0000000000035226

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PubMed articles on: Cancer & VTE/PE

Venous Thromboembolism Chemoprophylaxis Adherence Rates After Major Cancer Surgery

JAMA Netw Open. 2023 Sep 5;6(9):e2335311. doi: 10.1001/jamanetworkopen.2023.35311.

ABSTRACT

IMPORTANCE: Venous thromboembolism (VTE) represents a major source of preventable morbidity and mortality and is a leading cause of death in the US after cancer surgery. Previous research demonstrated variability in VTE chemoprophylaxis prescribing, although it is unknown how these rates compare with performance in the Veterans Health Administration (VHA).

OBJECTIVE: To determine VTE rates after cancer surgery, as well as rates of inpatient and outpatient (posthospital discharge) chemoprophylaxis adherence within the VHA.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study within 101 hospitals of the VHA health system included patients aged 41 years or older without preexisting bleeding disorders or anticoagulation usage who underwent surgical treatment for cancer with general surgery, thoracic surgery, or urology between January 1, 2015, and December 31, 2022. The VHA Corporate Data Warehouse, Pharmacy Benefits Management database, and the Veterans Affairs Surgical Quality Improvement Program database were used to identify eligible patients. Data analysis was conducted between January 2022 and July 2023.

EXPOSURES: Inpatient surgery for cancer with general surgery, thoracic surgery, or urology.

MAIN OUTCOMES AND MEASURES: Rates of postoperative VTE events within 30 days of surgery and VTE chemoprophylaxis adherence were determined. Multivariable Poisson regression was used to determine incidence-rate ratios of inpatient and postdischarge chemoprophylaxis adherence by surgical specialty.

RESULTS: Overall, 30 039 veterans (median [IQR] age, 67 [62-71] years; 29 386 men [97.8%]; 7771 African American or Black patients [25.9%]) who underwent surgery for cancer and were at highest risk for VTE were included. The overall postoperative VTE rate was 1.3% (385 patients) with 199 patients (0.7%) receiving a diagnosis during inpatient hospitalization and 186 patients (0.6%) receiving a diagnosis postdischarge. Inpatient chemoprophylaxis was ordered for 24 139 patients (80.4%). Inpatient chemoprophylaxis ordering rates were highest for patients who underwent procedures with general surgery (10 102 of 10 301 patients [98.1%]) and lowest for patients who underwent procedures with urology (11 471 of 17 089 patients [67.1%]). Overall, 3142 patients (10.5%) received postdischarge chemoprophylaxis, with notable variation by specialty.

CONCLUSIONS AND RELEVANCE: These findings indicate the overall VTE rate after cancer surgery within the VHA is low, VHA inpatient chemoprophylaxis rates are high, and postdischarge VTE chemoprophylaxis prescribing is similar to that of non-VHA health systems. Specialty and procedure variation exists for chemoprophylaxis and may be justified given the low risks of overall and postdischarge VTE.

PMID:37768664 | PMC:PMC10539988 | DOI:10.1001/jamanetworkopen.2023.35311

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PubMed articles on: Cardio-Oncology

Creatine and Resistance Training: A Combined Approach to Attenuate Doxorubicin-Induced Cardiotoxicity

Nutrients. 2023 Sep 19;15(18):4048. doi: 10.3390/nu15184048.

ABSTRACT

Doxorubicin (DOX), a potent chemotherapy agent, useful in the treatment of solid tumors, lymphomas, and leukemias, is limited by its potentially lethal cardiotoxicity. However, exercise has been consistently shown to mitigate the side effects of DOX, including cardiotoxicity. To date, most studies examining the relationship between exercise and DOX-induced cardiotoxicity have focused on aerobic exercise, with very few examining the role of anerobic activity. Therefore, this investigation explored the potential of creatine (CR) and resistance training (RT) in preserving cardiac health during DOX therapy. Male Sprague-Dawley rats were grouped into RT, RT + CR, sedentary (SED), and SED + CR, with each division further branching into saline (SAL) or DOX-treated subsets post-10 weeks of RT or SED activity. RT comprised progressive training utilizing specialized cages for bipedal stance feeding. CR-treated groups ingested water mixed with 1% CR monohydrate and 5% dextrose, while control animals received 5% dextrose. At week 10, DOX was administered (2 mg/kg/week) over 4-weeks to an 8 mg/kg cumulative dose. Cardiac function post-DOX treatment was assessed via transthoracic echocardiography. Left ventricular diameter during diastole was lower in DOX + CR, RT + DOX, and RT + CR + DOX compared to SED + DOX (p < 0.05). Additionally, cardiac mass was significantly greater in RT + CR + DOX SED + DOX animals (p < 0.05). These results suggest RT and CR supplementation, separately and in combination, could attenuate some measures of DOX-induced cardiotoxicity and may offer a cost-effective way to complement cancer treatments and enhance patient outcomes. More investigations are essential to better understand CR's prolonged effects during DOX therapy and its clinical implications.

PMID:37764831 | PMC:PMC10536171 | DOI:10.3390/nu15184048

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PubMed articles on: Cancer & VTE/PE

Survey on the Knowledge and Management of Cancer-Associated Thrombosis (CAT) in Haemato-Oncology Patients with Thrombocytopenia among Haematologists and Haematology Residents in Nigeria

West Afr J Med. 2023 Sep 28;40(9):956-961.

ABSTRACT

BACKGROUND: Arterial or venous thrombosis can complicate cancer, and 20% of cancer patients may develop venous thromboembolic disorders. Venous thromboembolism (VTE) is common in some haematologic malignancies and may coexist with thrombocytopenia in those haematologic malignancies. We carried out this survey to assess the knowledge and practice of haematologists and resident doctors in haematology in Nigeria regarding the management of thrombocytopenia and cancer-associated thrombosis.

METHODS: This was a survey that was shared electronically with participants who were consultant haematologists and resident doctors in haematology in Nigeria..

RESULTS: There were 106 respondents, 70 (66%) of which were consultant haematologists. About a third (30.2%) of the respondents saw 6-10 patients with blood malignancies monthly. Fifty-seven (53.8%) of the respondents carried out risk assessment in their patients for cancer-associated thrombosis (CAT); 63 (59.4%) of the respondents saw 1-2 cancer patients with thrombosis in 3 months. The most common mode of treatment was pharmacological - 94 (88%) respondents used low molecular weight heparin. The most common haematologic malignancies associated with thrombocytopenia were acute leukaemias (69; 67%). The most common decision taken by respondents was to stop anticoagulants and transfuse platelets because the most frequent concern was the risk of bleeding in this group of patients.

CONCLUSION: Many haematologists and haematology residents had a high level of awareness, knowledge and good practice regarding thrombocytopenia with CAT in haematooncology patients; however, there is a need for improved knowledge and unified protocols for treatment in line with newer management guidelines.

PMID:37767996

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PubMed articles on: Cardio-Oncology

Aortic Valve Stenosis and Cancer: Problems of Management

J Clin Med. 2023 Sep 6;12(18):5804. doi: 10.3390/jcm12185804.

ABSTRACT

Aortic valve stenosis and malignancy frequently coexist and share the same risk factors as atherosclerotic disease. Data reporting the prognosis of patients with severe aortic stenosis and cancer are limited. Tailoring the correct and optimal care for cancer patients with severe aortic stenosis is complex. Cancer patients may be further disadvantaged by aortic stenosis if it interferes with their treatment by increasing the risk associated with oncologic surgery and compounding the risks associated with cardiotoxicity and heart failure (HF). Surgical valve replacement, transcatheter valve implantation, balloon valvuloplasty, and medical therapy are possible treatments for aortic valve stenosis, but when malignancy is present, the choice between these options must take into account the stage of cancer and associated treatment, expected outcome, and comorbidities. Physical examination and Doppler echocardiography are critical in the diagnosis and evaluation of aortic stenosis. The current review considers the available data on the association between aortic stenosis and cancer and the therapeutic options.

PMID:37762745 | PMC:PMC10532214 | DOI:10.3390/jcm12185804

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PubMed articles on: Cancer & VTE/PE

Venous thromboembolism prophylaxis for hospitalized adult patients: a survey of US health care providers on attitudes and practices

Res Pract Thromb Haemost. 2023 Aug 7;7(6):102168. doi: 10.1016/j.rpth.2023.102168. eCollection 2023 Aug.

 

ABSTRACT

Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, the process by which hypoxia promotes the formation of a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic and hypoxic HCC cells were collected to induce fibroblast activation in vitro and PMN formation in vivo. The micro RNA (miR) profiles of the exosomes were sequenced to identify differentially expressed miRNAs. Gain- and loss-of-function analyses were performed to investigate miR-4508 function. Dual-luciferase, western blotting, and real-time reverse transcription-PCR analyses were used to identify the direct targets of miR-4508 and its downstream signaling pathways. To demonstrate the roles of hypoxic tumor-derived exosomes (H-TDEs) and miR-4508 in the lung metastasis of liver cancer, H22 tumor cells were injected through the tail vein of mice. Blood plasma-derived exosomes from patients with HCC who underwent transarterial chemoembolization (TACE) were applied to determine clinical correlations. Results: We demonstrated that H-TDEs activated lung fibroblasts and facilitated PMN formation, thereby promoting lung metastasis in mice. Screening for upregulated exosomal miRNAs revealed that miR-4508 and its target, regulatory factor X1 (RFX1), were involved in H-TDE-induced lung PMN formation. Moreover, miR-4508 was significantly upregulated in plasma exosomes derived from patients with HCC after TACE. We confirmed that the p38 MAPK-NF-κB signaling pathway is involved in RFX1 knockdown-induced fibroblast activation and PMN formation. In addition, IL17A, a downstream target of RFX1, was identified as a link between RFX1 knockdown and p38 MAPK activation in fibroblasts. Conclusion: Hypoxia enhances the release of TDEs enriched with miR-4508, thereby promoting lung PMN formation by targeting the RFX1-IL17A-p38 MAPK-NF-κB pathway. These findings highlight a novel mechanism underlying hypoxia-induced pulmonary metastasis of HCC.

PMID:37781522 | PMC:PMC10539707 | DOI:10.7150/ijbs.86767

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PubMed articles on: Cancer & VTE/PE

Anticoagulation for the treatment of septic cerebral venous sinus thrombosis in the setting of pediatric sinogenic and otogenic intracranial infections

Neurosurg Focus. 2023 Oct;55(4):E8. doi: 10.3171/2023.7.FOCUS23374.

ABSTRACT

OBJECTIVE: Septic cerebral venous sinus thrombosis (CVST) is a recognized complication of pediatric sinogenic and otogenic intracranial infections. The optimal treatment paradigm remains controversial. Proponents of anticoagulation highlight its role in preventing thrombus propagation and promoting recanalization, while others cite the risk of hemorrhagic complications, especially after a neurosurgical procedure for an epidural abscess or subdural empyema. Here, the authors investigated the diagnosis, management, and outcomes of pediatric patients with sinogenic or otogenic intracranial infections and a septic CVST.

METHODS: All patients 21 years of age or younger, who presented with an intracranial infection in the setting of sinusitis or otitis media and who underwent neurosurgical treatment at Connecticut Children's, Rady Children's Hospital-San Diego, or Ann and Robert H. Lurie Children's Hospital of Chicago from March 2015 to March 2023, were retrospectively reviewed. Demographic, clinical, and radiological data were systematically collated.

RESULTS: Ninety-six patients were treated for sinusitis-related and/or otitis media-related intracranial infections during the study period, 15 (15.6%) of whom were diagnosed with a CVST. Of the 60 patients who presented prior to the COVID-19 pandemic, 6 (10.0%) were diagnosed with a septic CVST, whereas of the 36 who presented during the COVID-19 pandemic, 9 (25.0%) had a septic CVST (p = 0.050). The superior sagittal sinus was involved in 12 (80.0%) patients and the transverse and/or sigmoid sinuses in 4 (26.7%). Only 1 (6.7%) patient had a fully occlusive thrombus. Of the 15 patients with a septic CVST, 11 (73.3%) were initiated on anticoagulation at a median interval of 4 (IQR 3-5) days from the most recent neurosurgical procedure. Five (45.5%) patients who underwent anticoagulation demonstrated complete recanalization on follow-up imaging, and 4 (36.4%) had partial recanalization. Three (75.0%) patients who did not undergo anticoagulation demonstrated complete recanalization, and 1 (25.0%) had partial recanalization. None of the patients treated with anticoagulation experienced hemorrhagic complications.

CONCLUSIONS: Septic CVST is frequently identified among pediatric patients undergoing neurosurgical intervention for sinogenic and/or otogenic intracranial infections and may have become more prevalent during the COVID-19 pandemic. Anticoagulation can be used safely in the acute postoperative period if administered cautiously, in a monitored setting, and with interval cross-sectional imaging. However, some patients exhibit excellent outcomes without anticoagulation, and further studies are needed to identify those who may benefit the most from anticoagulation.

PMID:37778041 | DOI:10.3171/2023.7.FOCUS23374

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PubMed articles on: Cardio-Oncology

Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway

Toxicol In Vitro. 2023 Sep 26;93:105704. doi: 10.1016/j.tiv.2023.105704. Online ahead of print.

ABSTRACT

Trastuzumab (TRZ) is a novel targeted anti-tumor agent that significantly improve the survival of patients with human epidermal growth factor receptor (HER2) positive breast cancer. However, its clinical application is limited due to the side effects of cardiotoxicity. Osthole (OST), a coumarin derivative isolated from Cnidium monnieri (L.) Cusson, has previously demonstrated cardioprotective effects. The aim of this study was to observe the protective effect of OST on TRZ-induced cardiomyocytes damage and to explore its potential mechanism. The results showed that OST pretreatment could significantly inhibit TRZ-induced cardiomyocytes damage, markedly increase the ratio of LC3II/I and Beclin-1 protein expression, and reduce the protein expression of p62. OST pretreatment significantly attenuated oxidative stress and apoptosis induced by TRZ, as evidenced by reducing intracellular ROS level, the Bax/Bcl-2 ratio, and Caspase-3 protein expression. Additionally, OST markedly increased the phosphorylation level of p38MAPK and decreased the mTOR phosphorylation level. However, the effects of OST on enhancing autophagy, reducing oxidative stress, apoptosis, and the phosphorylation level of mTOR were reversed after the addition of 3-MA or SB203580. Molecular docking results indicated that OST exerted a good binding ability with the p38MAPK protein. Our findings suggested that OST could protect TRZ-induced cardiomyocytes damage by enhancing autophagy via the p38MAPK/mTOR signaling pathway.

PMID:37769856 | DOI:10.1016/j.tiv.2023.105704

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PubMed articles on: Cardio-Oncology

Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1

Aging (Albany NY). 2023 Sep 28;15. doi: 10.18632/aging.205062. Online ahead of print.

ABSTRACT

Doxorubicin (DOX) is a potent chemotherapeutic drug used for treating various cancers. However, its clinical use is limited due to its severe cardiotoxicity, which often results in high mortality rates. Sheng-Mai-Yin (SMY), a Traditional Chinese medicine (TCM) prescription, has been reported to exert a cardioprotective effect in various cardiovascular diseases, including DOX-induced cardiotoxicity (DIC). This study aimed to provide novel insights into the underlying cardioprotective mechanism of SMY. SMY, composed of Codonopsis pilosula (Franch.), Ophiopogon japonicus (Thunb.), and Schisandra chinensis (Turcz.) at a ratio of 3:2:1, was intragastrically administered to male C57BL/6 mice for five days prior to the intraperitoneal injection of mitoTEMPO. One day later, DOX was intraperitoneally injected. Hematoxylin-eosin staining and Sirius red staining were carried out to estimate the pharmacological effect of SMY on cardiotoxicity. Mitochondrial function and ferroptosis biomarkers were also examined. AAV was utilized to overexpress Hmox1 to confirm whether Hmox1-mediated ferroptosis is associated with the cardioprotective effect of SMY on DOX-induced cardiotoxicity. The findings revealed that SMY therapy reduced the number of damaged cardiomyocytes. SMY therapy also reversed the inductions of cardiac MDA, serum MDA, LDH, and CK-MB contents, which dramatically decreased nonheme iron levels. In the meantime, SMY corrected the changes to ferroptosis indices brought on by DOX stimulation. Additionally, Hmox1 overexpression prevented SMY's ability to reverse cardiotoxicity. Our results showed that SMY effectively restrained lipid oxidation, reduced iron overload, and inhibited DOX-induced ferroptosis and cardiotoxicity, possibly via the mediation of Hmox1.

PMID:37770231 | DOI:10.18632/aging.205062

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PubMed articles on: Cardio-Oncology

Usefulness of Longitudinal Strain to Assess Cancer Therapy-Related Cardiac Dysfunction and Immune Checkpoint Inhibitor-Induced Myocarditis

Pharmaceuticals (Basel). 2023 Sep 14;16(9):1297. doi: 10.3390/ph16091297.

ABSTRACT

Longitudinal strain (LS) measured by echocardiography has been reported to be useful not only for the diagnosis and risk stratification of various cardiac diseases, but also in cardio-oncology. Most previous studies have been conducted on patients undergoing treatment with anthracyclines and human epidermal growth factor receptor 2-targeted therapies. Existing guidelines recommend that global LS (GLS) should be measured before and after the administration of cancer drugs. This recommendation is based on many reports showing that a decline in GLS is indicative of early or mild cancer therapy-related cardiac dysfunction. The main purpose of this article is to provide insight into the importance of LS in patients undergoing cancer treatment and highlight the role of LS evaluation in patients undergoing immune checkpoint inhibitor (ICI) treatment, which is being used with increasing frequency. Among cancer drug therapies, immune checkpoint inhibitors (ICIs) have an important place in cancer treatment and are used for the treatment of many types of cancer. Although the efficacy of ICIs in cancer treatment has been reported, immune-related adverse events (irAEs) have also been reported. Among these irAEs, cardiovascular complications, although rare, are recognized as important adverse events that may result in ICI treatment discontinuation. Myocarditis is one severe adverse event associated with ICIs, and it is important to standardize diagnostic and therapeutic approaches to it. Several studies have reported a relationship between LS and cardiac complications associated with ICIs which may contribute to the early diagnosis of ICI-induced cardiac complications.

PMID:37765105 | PMC:PMC10535915 | DOI:10.3390/ph16091297

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PubMed articles on: Cancer & VTE/PE

Real-world data emulating randomized controlled trials of non-vitamin K antagonist oral anticoagulants in patients with venous thromboembolism

BMC Med. 2023 Sep 29;21(1):375. doi: 10.1186/s12916-023-03069-1.