219. Smith JD, Paty PB, Guillem JG, et al. Anastomotic leak is not associated with oncologic outcome in

patients undergoing low anterior resection for rectal cancer. Ann Surg 2012;256(6):1034–1038.

220. Matthiessen P, Hallbook O, Andersson M, et al. Risk factors for anastomotic leakage after anterior

resection of the rectum. Colorectal Dis 2004; 6(6):462–469.

221. Tan WS, Tang CL, Shi L, et al. Meta-analysis of defunctioning stomas in low anterior resection for

rectal cancer. Br J Surg 2009;96(5):462–472.

222. Machado M, Hallbook O, Goldman S, et al. Defunctioning stoma in low anterior resection with

colonic pouch for rectal cancer: a comparison between two hospitals with a different policy. Dis

Colon Rectum 2002; 45(7):940–945.

223. Rondelli F, Reboldi P, Rulli A, et al. Loop ileostomy versus loop colostomy for fecal diversion after

colorectal or coloanal anastomosis: a meta-analysis. Int J Colorect Dis 2009;24(5):479–488.

224. Chun LJ, Haigh PI, Tam MS, et al. Defunctioning loop ileostomy for pelvic anastomoses: predictors

of morbidity and nonclosure. Dis Colon Rectum 2012;55(2):167–174.

225. Marr R, Birbeck K, Garvican J, et al. The modern abdominoperineal excision: the next challenge

after total mesorectal excision. Ann Surg 2005;242(1):74–82.

226. Perdawood SK, Lund T. Extralevator versus standard abdominoperineal excision for rectal cancer.

Tech Coloproctol 2014;19(3):145–152.

227. Musters GD, Buskens CJ, Bemelman WA, et al. Perineal wound healing after abdominoperineal

resection for rectal cancer: a systematic review and meta-analysis. Dis Colon Rectum

2014;57(9):1129–1139.

228. Yu HC, Peng H, He XS, et al. Comparison of short- and long-term outcomes after extralevator

abdominoperineal excision and standard abdominoperineal excision for rectal cancer: a systematic

review and meta-analysis. Int J Colorect Dis 2014;29(2):183–191.

229. de Campos-Lobato LF, Stocchi L, Dietz DW, et al. Prone or lithotomy positioning during an

abdominoperineal resection for rectal cancer results in comparable oncologic outcomes. Dis Colon

Rectum 2011;54(8):939–946.

230. Lujan J, Valero G, Hernandez Q, et al. Randomized clinical trial comparing laparoscopic and open

1822

surgery in patients with rectal cancer. Br J Surg 2009;96(9):982–989.

231. Ng KH, Ng DC, Cheung HY, et al. Laparoscopic resection for rectal cancers: lessons learned from

579 cases. Ann Surg 2009;249(1):82–86.

232. Greenblatt DY, Rajamanickam V, Pugely AJ, et al. Short-term outcomes after laparoscopic-assisted

proctectomy for rectal cancer: results from the ACS NSQIP. J Am Coll Surg 2011;212(5):844–854.

233. Yeo H, Niland J, Milne D, et al. Incidence of minimally invasive colorectal cancer surgery at

National Comprehensive Cancer Network centers. J Natl Cancer Inst 2015;107(1):362.

234. Jayne DG, Thorpe HC, Copeland J, et al. Five-year follow-up of the Medical Research Council

CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg

2010;97(11):1638–1645.

235. Jeong SY, Park JW, Nam BH, et al. Open versus laparoscopic surgery for mid-rectal or low-rectal

cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label,

non-inferiority, randomised controlled trial. Lancet Oncol 2014;15(7):767–774.

236. van der Pas MH, Haglind E, Cuesta MA, et al. Laparoscopic versus open surgery for rectal cancer

(COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 2013;14(3):210–218.

237. Vithiananthan S, Cooper Z, Betten K, et al. Hybrid laparoscopic flexure takedown and open

procedure for rectal resection is associated with significantly shorter length of stay than equivalent

open resection. Dis Colon Rectum 2001;44(7):927–935.

238. Xiong B, Ma L, Zhang C, et al. Robotic versus laparoscopic total mesorectal excision for rectal

cancer: a meta-analysis. J Surg Res 2014;188(2):404–414.

239. Collinson FJ, Jayne DG, Pigazzi A, et al. An international, multicentre, prospective, randomised,

controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery

for the curative treatment of rectal cancer. Int J Colorect Dis 2012;27(2):233–241.

240. de Lacy AM, Rattner DW, Adelsdorfer C, et al. Transanal natural orifice transluminal endoscopic

surgery (NOTES) rectal resection: “down-to-up” total mesorectal excision (TME)–short-term

outcomes in the first 20 cases. Surg Endosc 2013;27(9):3165–3172.

241. Rouanet P, Mourregot A, Azar CC, et al. Transanal endoscopic proctectomy: an innovative

procedure for difficult resection of rectal tumors in men with narrow pelvis. Dis Colon Rectum

2013;56(4):408–415.

242. Prolongation of the disease-free interval in surgically treated rectal carcinoma. Gastrointestinal

Tumor Study Group. N Eng J Med 1985;312(23):1465–1472.

243. Fisher B, Wolmark N, Rockette H, et al. Postoperative adjuvant chemotherapy or radiation therapy

for rectal cancer: results from NSABP protocol R-01. J Natl Cancer Inst 1988;80:21–29.

244. Gerard A, Buyse M, Nordlinger B, et al. Preoperative radiotherapy as adjuvant treatment in rectal

cancer: final results of a randomized study of the European Organization for Research and

Treatment of Cancer (EORTC). Ann Surg 1988;208:606–614.

245. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total

mesorectal excision for resectable rectal cancer. N Eng J Med 2001;345(9):638–646.

246. O’Connell MJ, Martenson JA, Wieand HS, et al. Improving adjuvant therapy for rectal cancer by

combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Eng J

Med 1994;331(8):502–507.

247. Smalley SR, Benedetti JK, Williamson SK, et al. Phase III trial of fluorouracil-based chemotherapy

regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol

2006;24(22):3542–3547.

248. Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal

cancer. N Eng J Med 2006;355(11):1114–1123.

249. Gerard JP, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent

fluorouracil and leucovorin in T3–4 rectal cancers: results of FFCD 9203. J Clin Oncol

2006;24(28):4620–4625.

250. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for

rectal cancer. N Eng J Med 2004;351(17):1731–1740.

251. Roh MS, Colangelo LH, O’Connell MJ, et al. Preoperative multimodality therapy improves diseasefree survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol

2009;27(31):5124–5130.

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252. O’Connell MJ, Colangelo LH, Beart RW, et al. Capecitabine and oxaliplatin in the preoperative

multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant

Breast and Bowel Project trial R-04. J Clin Oncol 2014;32(18):1927–1934.

253. Hofheinz RD, Wenz F, Post S, et al. Chemoradiotherapy with capecitabine versus fluorouracil for

locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial. Lancet

Oncol 2012;13(6):579–588.

254. Gerard JP, Azria D, Gourgou-Bourgade S, et al. Comparison of two neoadjuvant chemoradiotherapy

regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige

2. J Clin Oncol 2010;28(10):1638–1644.

255. Aschele C, Cionini L, Lonardi S, et al. Primary tumor response to preoperative chemoradiation with

or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01

randomized phase III trial. J Clin Oncol 2011;29(20):2773–2780.

256. Rodel C, Liersch T, Becker H, et al. Preoperative chemoradiotherapy and postoperative

chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal

cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol

2012;13(7):679–687.

257. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomized trial

comparing preoperative short-course radiotherapy with preoperative conventionally fractionated

chemoradiation for rectal cancer. Br J Surg 2006;93(10):1215–1223.

258. Ngan SY, Burmeister B, Fisher RJ, et al. Randomized trial of short-course radiotherapy versus longcourse chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: TransTasman Radiation Oncology Group trial 01.04. J Clin Oncol 2012;30(31):3827–3833.

259. Schrag D, Chemotherapy alone or chemotherapy plus radiation therapy in treating patients with

locally advanced rectal cancer undergoing surgery. [cited 3/18/2015]; available from

http://clinicaltrials.gov/show/NCT01515787.

260. Bosset JF, Calais G, Mineur L, et al. Fluorouracil-based adjuvant chemotherapy after preoperative

chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study.

Lancet Oncol 2014; 15(2):184–190.

261. Petersen SH, Harling H, Kirkeby LT, et al. Postoperative adjuvant chemotherapy in rectal cancer

operated for cure. Cochrane Database Syst Rev 2012;3:CD004078.

262. Biagi JJ, Raphael M, Mackillop WJ, et al. Association between time to initiation of adjuvant

chemotherapy and survival in colorectal cancer: a systemic review and meta-analysis. JAMA

2011;305(22):2335–2342.

263. Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin followed by

synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined

poor-risk rectal cancer. J Clin Oncol 2006;24(4):668–674.

264. Fernandez-Martos C, Pericay C, Aparicio J, et al. Phase II, randomized study of concomitant

chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX)

compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in

magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study.

J Clin Oncol 2010;28(5):859–865.

265. Cercek A, Goodman KA, Hajj C, et al. Neoadjuvant chemotherapy first, followed by chemoradiation

and then surgery, in the management of locally advanced rectal cancer. J Natl Compr Cancer Netw

2014; 12(4):513–519.

266. Marijnen CA, Kapiteijn E, van de Velde CJ, et al. Acute side effects and complications after shortterm preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer:

report of a multicenter randomized trial. J Clin Oncol 2002;20(3):817–825.

267. Paun BC, Cassie S, MacLean AR, et al. Postoperative complications following surgery for rectal

cancer. Ann Surg 2010;251(5):807–818.

268. Peeters KC, van de Velde CJ, Leer JW, et al. Late side effects of short-course preoperative

radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel

dysfunction in irradiated patients–a Dutch colorectal cancer group study. J Clin Oncol

2005;23(25):6199–6206.

269. Hendren SK, O’Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high

following surgery for rectal cancer. Ann Surg 2005;242(2):212–223.

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