expertise in institutions, which plays a significant role in pediatric surgical outcomes.

References

1. Wilson JM, DiFiore JW. Respiratory physiology and care. In: Coran AG, Adzick NS, eds. Pediatric

Surgery. Philadelphia, PA: Elsevier Mosby; 2012.

2. Fraga MV, Guttentag S. Lung development. In: Gleason CA, ed. Avery’s Diseases of the Newborn a. S.

U. D. California: Los Angeles; 2012.

3. Hooper SB, Harding R. Fetal lung liquid: a major determinant of the growth and functional

development of the fetal lung. Clin Exp Pharmacol Physiol 1995;22(4):235–247.

4. Harding R, Hooper SB. Regulation of lung expansion and lung growth before birth. J Appl

Physiol(1985) 1996;81(1):209–224.

5. Vilos GA, Liggins GC. Intrathoracic pressures in fetal sheep. J Dev Physiol 1982;4(4):247–256.

6. Nardo L, Maritz G, Harding R, et al. Changes in lung structure and cellular division induced by

tracheal obstruction in fetal sheep. Exp Lung Res 2000;26(2):105–119.

7. Schittny JC, Miserocchi G, Sparrow MP. Spontaneous peristaltic airway contractions propel lung

liquid through the bronchial tree of intact and fetal lung explants. Am J Respir Cell Mol Biol

2000;23(1):11–18.

8. Bellotti M, Pennati G, De Gasperi C, et al. Role of ductus venosus in distribution of umbilical blood

flow in human fetuses during second half of pregnancy. Am J Physiol Heart Circ Physiol

2000;279(3):H1256–H1263.

9. Sutton MS, Theard MA, Bhatia SJ, et al. Changes in placental blood flow in the normal human fetus

with gestational age. Pediatr Res 1990;28(4):383–387.

10. Gill RW, Trudinger BJ, Garrett WJ, et al. Fetal umbilical venous flow measured in utero by pulsed

Doppler and B-mode ultrasound. I. Normal pregnancies. Am J Obstet Gynecol 1981;139(6):720–725.

11. Ferrazzi E, Bellotti M, Galan H, et al. Doppler investigation in intrauterine growth restriction–from

qualitative indices to flow measurements: a review of the experience of a collaborative group. Ann

N Y Acad Sci 2001;943:316–325.

12. Wood WG, Weatherall DJ. Haemoglobin synthesis during human foetal development. Nature

1973;244(5412):162–165.

13. Polin RA, Fox WW, Abman SH. Fetal and Neonatal Physiology. 4th ed. Philadelphia, PA:

Elsevier/Saunders; 2011.

14. Schroeder WA, Shelton JR, Shelton JB, et al. The amino acid sequence of the alpha chain of human

fetal hemoglobin. Biochemistry 1963;2:1353–1357.

15. Willson DF, Notter RH. The future of exogenous surfactant therapy. Respir Care 2011;56(9):1369–

1386; discussion 1386–1388.

16. Lacaze-Masmonteil T. Expanded use of surfactant therapy in newborns. Clin Perinatol

2007;34(1):179–189, ix.

17. Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short- and long-term

morbidity in very low birthweight infants. Cochrane Database Syst Rev 2011;(10):CD000501.

18. Shenai JP. Vitamin A supplementation in very low birth weight neonates: rationale and evidence.

Pediatrics 1999;104(6):1369–1374.

19. Kuhlmann RS, Warsof SL, Levy DL, et al. Fetal sacrococcygeal teratoma. Fetal Ther 1987;2(2):95–

100.

20. Hedrick HL, Flake AW, Crombleholme TM, et al. Sacrococcygeal teratoma: prenatal assessment,

fetal intervention, and outcome. J Pediatr Surg 2004;39(3):430–438; discussion 430–438.

21. Olutoye OO, Johnson MP, Coleman BG, et al. Abnormal umbilical cord doppler sonograms may

predict impending demise in fetuses with sacrococcygeal teratoma. A report of two cases. Fetal

Diagn Ther 2004; 19(1):35–39.

22. Areechon W, Reid L. Hypoplasia of lung with congenital diaphragmatic hernia. Br Med J

1963;1(5325):230–233.

23. Pringle KC. Lung development in congenital diaphragmatic hernia. In: Puri P, ed. Congenital

Diaphragmatic Hernia. Basel: Karger; 1989.

2870

24. Shehata SM, Sharma HS, van der Staak FH, et al. Remodeling of pulmonary arteries in human

congenital diaphragmatic hernia with or without extracorporeal membrane oxygenation. J Pediatr

Surg 2000;35(2):208–215.

25. Hedrick MH, Estes JM, Sullivan KM, et al. Plug the lung until it grows (PLUG): a new method to

treat congenital diaphragmatic hernia in utero. J Pediatr Surg 1994;29(5):612–617.

26. Harrison MR, Keller RL, Hawgood SB, et al. A randomized trial of fetal endoscopic tracheal

occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 2003;349(20):1916–1924.

27. Jani JC, Nicolaides KH, Gratacós E, et al. Severe diaphragmatic hernia treated by fetal endoscopic

tracheal occlusion. Ultrasound Obstet Gynecol 2009;34(3):304–310.

28. Deprest J, Brady P, Nicolaides K, et al. Prenatal management of the fetus with isolated congenital

diaphragmatic hernia in the era of the TOTAL trial. Semin Fetal Neonatal Med 2014;19(6):338–348.

29. McDonough RJ, Niven AS, Havenstrite KA. Congenital pulmonary airway malformation: a case

report and review of the literature. Respir Care 2012; 57(2):302–306.

30. Sylvester KG, Albanese CT. Congenital bronchopulmonary malformations. In: Holcomb GW,

Murphy PJ, Ostlie DJ, eds. Ashcraft’s Pediatric Surgery. 5th ed. Philadelphia, PA: Saunder’s; 2010.

31. Rice HE, Estes JM, Hedrick MH, et al. Congenital cystic adenomatoid malformation: a sheep model

of fetal hydrops. J Pediatr Surg 1994;29(5):692–696.

32. Adzick NS, Harrison MR, Crombleholme TM, et al. Fetal lung lesions: management and outcome.

Am J Obstet Gynecol 1998;179(4):884–889.

33. Crombleholme TM, Coleman B, Hedrick H, et al. Cystic adenomatoid malformation volume ratio

predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. J Pediatr

Surg 2002;37(3):331–338.

34. Peranteau WH, Wilson RD, Liechty KW, et al. Effect of maternal betamethasone administration on

prenatal congenital cystic adenomatoid malformation growth and fetal survival. Fetal Diagn Ther

2007;22(5):365–371.

35. Tsao K, Hawgood S, Vu L, et al. Resolution of hydrops fetalis in congenital cystic adenomatoid

malformation after prenatal steroid therapy. J Pediatr Surg 2003;38(3):508–510.

36. Sydorak RM, Hirose S, Sandberg PL, et al. Chorioamniotic membrane separation following fetal

surgery. J Perinatol 2002;22(5):407–410.

37. Wilson RD, Johnson MP, Crombleholme TM, et al. Chorioamniotic membrane separation following

open fetal surgery: pregnancy outcome. Fetal Diagn Ther 2003;18(5):314–320.

38. Deprest J, Gratacos E, Nicolaides KH; FETO Task Group. Fetoscopic tracheal occlusion (FETO) for

severe congenital diaphragmatic hernia: evolution of a technique and preliminary results.

Ultrasound Obstet Gynecol 2004;24(2):121–126.

39. DiBlasi RM, Richardson CP, Hansen T. Pulmonary physiology of the newborn. In: Gleason CA,

Devaskar SU, Avery ME, eds. Avery’s Diseases of the Newborn. Philadelphia, PA: Elsevier/Saunders:

2012;598–611.

40. Fry DL, Hyatt RE. Pulmonary mechanics. A unified analysis of the relationship between pressure,

volume and gasflow in the lungs of normal and diseased human subjects. Am J Med 1960;29:672–

689.

41. Krieger I. Studies on mechanics of respiration in infancy. Am J Dis Child 1963;105:439–448.

42. Magnenant E, Rakza T, Riou Y, et al. Dynamic behavior of respiratory system during nasal

continuous positive airway pressure in spontaneously breathing premature newborn infants. Pediatr

Pulmonol 2004;37(6):485–491.

43. Polgar G, Kong GP. The nasal resistance of newborn infants. J Pediatr 1965;67(4):557–567.

44. Zimova-Herknerova M, Plavka R. Expired tidal volumes measured by hot-wire anemometer during

high-frequency oscillation in preterm infants. Pediatr Pulmonol 2006;41(5):428–433.

45. Dellaca RL, Ventura ML, Zannin E, et al. Measurement of total and compartmental lung volume

changes in newborns by optoelectronic plethysmography. Pediatr Res 2010;67(1):11–16.

46. Hulskamp G, Lum S, Stocks J, et al. Association of prematurity, lung disease and body size with

lung volume and ventilation inhomogeneity in unsedated neonates: a multicentre study. Thorax

2009;64(3):240–245.

47. Delivoria-Papadopoulos M, Levison H, Swyer PR. Intermittent positive pressure respiration as a

treatment in severe respiratory distress syndrome. Arch Dis Child 1965;40(213):474–479.

2871

48. Donn SM. Neonatal ventilators: how do they differ? J Perinatol 2009; 29(Suppl 2):S73–S78.

49. Becker MA, Donn SM. Real-time pulmonary graphic monitoring. Clin Perinatol 2007;34(1):1–17, v.

50. Singh J, Sinha SK, Clarke P, et al. Mechanical ventilation of very low birth weight infants: is

volume or pressure a better target variable? J Pediatr 2006;149(3):308–313.

51. Gray BW, Shaffer AW, Mychaliska GB. Advances in neonatal extracorporeal support: the role of

extracorporeal membrane oxygenation and the artificial placenta. Clin Perinatol 2012;39(2):311–

329.

52. Bartlett RH. Extracorporeal life support: history and new directions. Semin Perinatol 2005;29(1):2–

7.

53. Bartlett RH, Gazzaniga AB, Jefferies MR, et al. Extracorporeal membrane oxygenation (ECMO)

cardiopulmonary support in infancy. Trans Am Soc Artif Intern Organs 1976;22:80–93.

54. Duyndam A, Ista E, Houmes RJ, et al. Invasive ventilation modes in children: a systematic review

and meta-analysis. Crit Care 2011;15(1):R24.

55. Finer NN, Barrington KJ. Nitric oxide for respiratory failure in infants born at or near term.

Cochrane Database Syst Rev 2006;(4):CD000399.

56. Field D, Elbourne D, Hardy P, et al. Neonatal ventilation with inhaled nitric oxide vs. Ventilatory

support without inhaled nitric oxide for infants with severe respiratory failure born at or near term:

the INNOVO multicentre randomised controlled trial. Neonatology 2007;91(2):73–82.

57. El Shahed AI, Dargaville P, Ohlsson A, et al. Surfactant for meconium aspiration syndrome in full

term/near term infants. Cochrane Database Syst Rev 2007;(3):CD002054.

58. Stevens TP, Harrington EW, Blennow M, et al. Early surfactant administration with brief

ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or

at risk for respiratory distress syndrome. Cochrane Database Syst Rev 2007;(4):CD003063.

59. Greenough A, Dimitriou G, Prendergast M, et al. Synchronized mechanical ventilation for

respiratory support in newborn infants. Cochrane Database Syst Rev 2008;(1):CD000456.

60. Mugford M, Elbourne D, Field D. Extracorporeal membrane oxygenation for severe respiratory

failure in newborn infants. Cochrane Database Syst Rev 2008;(3):CD001340.

61. Itoh H, Ichiba S, Ujike Y, et al. Extracorporeal membrane oxygenation following pediatric cardiac

surgery: development and outcomes from a single center experience. Perfusion 2012;27(3):225–229.

62. Stolar CJ, Snedecor SM, Bartlett RH. Extracorporeal membrane oxygenation and neonatal

respiratory failure: experience from the extracorporeal life support organization. J Pediatr Surg

1991;26(5):563–571.

63. Bartlett RH, Gazzaniga AB, Toomasian J, et al. Extracorporeal membrane oxygenation (ECMO) in

neonatal respiratory failure. 100 cases. Ann Surg 1986;204(3):236–245.

64. Ortega M, Ramos AD, Platzker AC, et al. Early prediction of ultimate outcome in newborn infants

with severe respiratory failure. J Pediatr 1988;113(4):744–747.

65. Rivera RA, Butt W, Shann F. Predictors of mortality in children with respiratory failure: possible

indications for ECMO. Anaesth Intensive Care 1990;18(3):385–389.

66. Cilley RE, Zwischenberger JB, Andrews AF, et al. Intracranial hemorrhage during extracorporeal

membrane oxygenation in neonates. Pediatrics 1986;78(4):699–704.

67. Hirschl RB, Schumacher RE, Snedecor SN, et al. The efficacy of extracorporeal life support in

premature and low birth weight newborns. J Pediatr Surg 1993;28(10):1336–1340; discussion 1341.

68. Meinhardt JP, Annich GM, Miskulin J, et al. Thrombogenicity is not reduced when heparin and

phospholipid bonded circuits are used in a rabbit model of extracorporeal circulation. ASAIO J

2003;49(4):395–400.

69. Annich GM, Meinhardt JP, Mowery KA, et al. Reduced platelet activation and thrombosis in

extracorporeal circuits coated with nitric oxide release polymers. Crit Care Med 2000;28(4):915–

920.

70. Frost MC, Reynolds MM, Meyerhoff ME. Polymers incorporating nitric oxide releasing/generating

substances for improved biocompatibility of blood-contacting medical devices. Biomaterials

2005;26(14):1685–1693.

71. Zhang H, Annich GM, Miskulin J, et al. Nitric oxide-releasing fumed silica particles: synthesis,

characterization, and biomedical application. J Am Chem Soc 2003;125(17):5015–5024.

2872

72. Major TC, Brant DO, Burney CP, et al. The hemocompatibility of a nitric oxide generating polymer

that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model. Biomaterials

2011;32(26):5957–5969.

73. Major TC, Brant DO, Reynolds MM, et al. The attenuation of platelet and monocyte activation in a

rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials

2010;31(10):2736–2745.

74. Skrzypchak AM, Lafayette NG, Bartlett RH, et al. Effect of varying nitric oxide release to prevent

platelet consumption and preserve platelet function in an in vivo model of extracorporeal

circulation. Perfusion 2007;22(3):193–200.

75. Wu B, Gerlitz B, Grinnell BW, et al. Polymeric coatings that mimic the endothelium: combining

nitric oxide release with surface-bound active thrombomodulin and heparin. Biomaterials

2007;28(28):4047–4055.

76. Lewis DA, Gauger P, Delosh TN, et al. The effect of pre-ECLS ventilation time on survival and

respiratory morbidity in the neonatal population. J Pediatr Surg 1996;31(8):1110–1114; discussion

1114–1115.

77. von Allmen D, Ryckman FC. Cardiac arrest in the ECMO candidate. J Pediatr Surg 1991;26(2):143–

146.

78. del Nido PJ, Dalton HJ, Thompson AE, et al. Extracorporeal membrane oxygenator rescue in

children during cardiac arrest after cardiac surgery. Circulation 1992;86(5 Suppl):II300–II304.

79. Clark RH, Huckaby JL, Kueser TJ, et al. Low-dose nitric oxide therapy for persistent pulmonary

hypertension: 1-year follow-up. J Perinatol 2003;23(4):300–303.

80. Christou H, Van Marter LJ, Wessel DL, et al. Inhaled nitric oxide reduces the need for

extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the

newborn. Crit Care Med 2000;28(11):3722–3727.

81. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary

hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med

2000;342(7):469–474.

82. Bartlett RH. Extracorporeal life support for cardiopulmonary failure. Curr Probl Surg

1990;27(10):621–705.

83. Skinner SC, Hirschl RB, Bartlett RH. Extracorporeal life support. Semin Pediatr Surg 2006;15(4):242–

250.

84. MacLaren G, Combes A, Bartlett RH. Contemporary extracorporeal membrane oxygenation for

adult respiratory failure: life support in the new era. Intensive Care Med 2012;38(2):210–220.

85. Khoshbin E, Roberts N, Harvey C, et al. Poly-methyl pentene oxygenators have improved gas

exchange capability and reduced transfusion requirements in adult extracorporeal membrane

oxygenation. ASAIO J 2005;51(3):281–287.

86. Nishinaka T, Tatsumi E, Katagiri N, et al. Up to 151 days of continuous animal perfusion with

trivial heparin infusion by the application of a long-term durable antithrombogenic coating to a

combination of a seal-less centrifugal pump and a diffusion membrane oxygenator. J Artif Organs

2007;10(4):240–244.

87. Peek GJ, Killer HM, Reeves R, et al. Early experience with a polymethyl pentene oxygenator for

adult extracorporeal life support. ASAIO J 2002; 48(5):480–482.

88. Mendler N, Podechtl F, Feil G, et al. Seal-less centrifugal blood pump with magnetically suspended

rotor: rot-a-flot. Artif Organs 1995;19(7):620–624.

89. Talor J, Yee S, Rider A, et al. Comparison of perfusion quality in hollow-fiber membrane

oxygenators for neonatal extracorporeal life support. Artif Organs 2010;34(4):E110–E116.

90. Wang D, Zhou X, Liu X, et al. Wang-Zwische double lumen cannula-toward a percutaneous and

ambulatory paracorporeal artificial lung. ASAIO J 2008;54(6):606–611.

91. Bermudez CA, Rocha RV, Sappington PL, et al. Initial experience with single cannulation for

venovenous extracorporeal oxygenation in adults. Ann Thorac Surg 2010;90(3):991–995.

92. Gadepalli SK, Hirschl RB. Extracorporeal life support: updates and controversies. Semin Pediatr Surg

2015;24(1):8–11.

93. Bartlett RH, Andrews AF, Toomasian JM, et al. Extracorporeal membrane oxygenation for newborn

respiratory failure: forty-five cases. Surgery 1982;92(2):425–433.

2873

94. Kim A, Erickson K, Rana A, et al. Pushing the Boundaries of ECLS: Outcomes in < 34 week EGA

Neonates. Puerto Rico: American Pediatric Surgical Association; 2009.

95. Markestad T, Kaaresen PI, R⊘nnestad A, et al. Early death, morbidity, and need of treatment among

extremely premature infants. Pediatrics 2005;115(5):1289–1298.

96. Behrman RE, Butler AS, eds. Preterm Birth: Causes, Consequences, and Prevention. Washington, DC:

Institute of Medicine of the National Academics; 2006:1–4.

97. Hack M, Fanaroff AA. Outcomes of children of extremely low birthweight and gestational age in

the 1990s. Semin Neonatol 2000;5(2):89–106.

98. Rimensberger PC. Neonatal respiratory failure. Curr Opin Pediatr 2002; 14(3):315–321.

99. Ventre KM, Arnold JH. High frequency oscillatory ventilation in acute respiratory failure. Paediatr

Respir Rev 2004;5(4):323–332.

100. Gray BW, El-Sabbagh A, Rojas-Pena A, et al. Development of an artificial placenta IV: 24 hour

venovenous extracorporeal life support in premature lambs. ASAIO J 2012;58(2):148–154.

101. Seo T, Ito T, Iio K, et al. Experimental study on the hemodynamic effects of veno-arterial

extracorporeal membrane oxygenation with an automatically driven blood pump on puppies. Artif

Organs 1991;15(5):402–407.

102. Richardson DK, Corcoran JD, Escobar GJ, et al. SNAP-II and SNAPPE-II: simplified newborn illness

severity and mortality risk scores. J Pediatr 2001;138(1):92–100.

103. Parry G, Tucker J, Tarnow-Mordi W. CRIB II: an update of the clinical risk index for babies score.

Lancet 2003;361(9371):1789–1791.

104. Carvalho PR, Moreira ME, Sá RA, et al. SNAPPE-II application in newborns with very low birth

weight: evaluation of adverse outcomes in severe placental dysfunction. J Perinat Med

2011;39(3):343–347.

105. White JJ, Andrews HG, Risemberg H, et al. Prolonged respiratory support in newborn infants with

a membrane oxygenator. Surgery 1971;70(2):288–296.

106. Milligan DW. Failure of autoregulation and intraventricular haemorrhage in preterm infants. Lancet

1980;1(8174):896–898.

107. Tarby TJ, Volpe JJ. Intraventricular hemorrhage in the premature infant. Pediatr Clin North Am

1982;29(5):1077–1104.

108. Goldberg RN, Chung D, Goldman SL, et al. The association of rapid volume expansion and

intraventricular hemorrhage in the preterm infant. J Pediatr 1980;96(6):1060–1063.

109. Goldenberg RL. The management of preterm labor. Obstet Gynecol 2002;100(5 Pt 1):1020–1037.

110. Ballabh P. Pathogenesis and prevention of intraventricular hemorrhage. Clin Perinatol

2014;41(1):47–67.

111. Morrison JL, Botting KJ, Soo PS, et al. Antenatal steroids and the IUGR fetus: are exposure and

physiological effects on the lung and cardiovascular system the same as in normally grown fetuses?

J Pregnancy 2012;2012:839656.

112. Polyakov A, Cohen S, Baum M, et al. Patterns of antenatal corticosteroid prescribing 1998–2004.

Aust N Z J Obstet Gynaecol 2007;47(1):42–45.

113. Ikegami M, Polk DH, Jobe AH, et al. Effect of interval from fetal corticosteroid treatment to

delivery on postnatal lung function of preterm lambs. J Appl Physiol(1985) 1996;80(2):591–597.

114. Liley HG, White RT, Warr RG, et al. Regulation of messenger RNAs for the hydrophobic surfactant

proteins in human lung. J Clin Invest 1989; 83(4):1191–1197.

115. Snyder JM, Regulation of alveolarization. In: Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal

Physiology. Philadelphia, PA: Elsevier/Saunders; 2011.

116. Davidson A, Flick RP. Neurodevelopmental implications of the use of sedation and analgesia in

neonates. Clin Perinatol 2013;40(3):559–573.

117. Hansen TG. Anesthesia-related neurotoxicity and the developing animal brain is not a significant

problem in children. Paediatr Anaesth 2015; 25(1):65–72.

118. Olsen EA, Brambrink AM. Anesthetic neurotoxicity in the newborn and infant. Curr Opin

Anaesthesiol 2013;26(5):535–542.

119. Sanders RD, Hassell J, Davidson AJ, et al. Impact of anaesthetics and surgery on

neurodevelopment: an update. Br J Anaesth 2013;110(Suppl 1):i53–i72.

2874

120. Zhang H, Du L, Du Z, et al. Association between childhood exposure to single general anesthesia

and neurodevelopment: a systematic review and meta-analysis of cohort study. J Anesth

2015;29(5):749–757.

121. Raju TN. Developmental physiology of late and moderate prematurity. Semin Fetal Neonatal Med

2012;17(3):126–131.

122. Whyte RK. Neonatal management and safe discharge of late and moderate preterm infants. Semin

Fetal Neonatal Med 2012;17(3):153–158.

123. Flenady VJ, Woodgate PG. Radiant warmers versus incubators for regulating body temperature in

newborn infants. Cochrane Database Syst Rev 2003;(4):CD000435.

124. Afsar FS. Skin care for preterm and term neonates. Clin Exp Dermatol 2009;34(8):855–858.

125. Shwayder T, Akland T. Neonatal skin barrier: structure, function, and disorders. Dermatol Ther

2005;18(2):87–103.

126. McGurk V, Holloway B, Crutchley A, et al. Skin integrity assessment in neonates and children.

Paediatr Nurs 2004;16(3):15–18.

127. Bhutta ZA, Darmstadt GL, Hasan BS, et al. Community-based interventions for improving perinatal

and neonatal health outcomes in developing countries: a review of the evidence. Pediatrics

2005;115(2 Suppl):519–617.

128. Khashu M, Chessex P, Chanoine JP. Iodine overload and severe hypothyroidism in a premature

neonate. J Pediatr Surg 2005;40(2):E1–E4.

129. Baharestani MM. An overview of neonatal and pediatric wound care knowledge and considerations.

Ostomy Wound Manage 2007;53(6):34–36, 38, 40, passim.

130. Binet A, Gelas T, Jochault-Ritz S, et al. VAC® therapy a therapeutic alternative in giant

omphalocele treatment: a multicenter study. J Plast Reconstr Aesthet Surg 2013;66(12):e373–e375.

131. Gutierrez IM, Gollin G. Negative pressure wound therapy for children with an open abdomen.

Langenbecks Arch Surg 2012;397(8):1353–1357.

132. Oeltjen JC, Panos AL, Salerno TA, et al. Complete vacuum-assisted sternal closure following

neonatal cardiac surgery. J Card Surg 2009;24(6):748–750.

133. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? Where? Why? Lancet

2005;365(9462):891–900.

134. Liu L, Johnson HL, Cousens S, et al; Child Health Epidemiology Reference Group of WHO and

UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for

2010 with time trends since 2000. Lancet 2012;379(9832):2151–2161.

135. Wynn JL, Wong HR. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol

2010;37(2):439–479.

136. Cuenca AG, Wynn JL, Moldawer LL, et al. Role of innate immunity in neonatal infection. Am J

Perinatol 2013;30(2):105–112.

137. Healy CM, Palazzi DL, Edwards MS, et al. Features of invasive staphylococcal disease in neonates.

Pediatrics 2004;114(4):953–961.

138. Basha S, Surendran N, Pichichero M, Immune responses in neonates. Expert Rev Clin Immunol

2014;10(9):1171–1184.

139. Haque KN. Defining common infections in children and neonates. J Hosp Infect 2007;65(Suppl

2):110–114.

140. Levy O, Martin S, Eichenwald E, et al. Impaired innate immunity in the newborn: newborn

neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics

1999;104(6):1327–1333.

141. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol

2008;8(10):776–787.

142. Melvan JN, Bagby GJ, Welsh DA, et al. Neonatal sepsis and neutrophil insufficiencies. Int Rev

Immunol 2010;29(3):315–348.

143. Fierson WM; American Academy of Pediatrics Section on Ophthalmology; American Academy of

Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American

Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of

prematurity. Pediatrics 2013;131(1):189–195.

2875