http://surgerybook.net/

210. Allione A, Bernabei P, Bosticardo M, et al. Nitric oxide suppresses human T lymphocyte

proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis. J

Immunol 1999;163(8):4182–4191.

211. Ou J, Carlos TM, Watkins SC, et al. Differential effects of nonselective nitric oxide synthase (NOS)

and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and

neutrophil accumulation during endotoxemia. Nitric Oxide 1997;1(5):404–416.

212. Isobe M, Katsuramaki T, Hirata K, et al., Beneficial effects of inducible nitric oxide synthase

inhibitor on reperfusion injury in the pig liver. Transplantation 1999;68(6):803–813.

213. Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in

macrophages. Proc Natl Acad Sci U S A 1997;94(13):6954–6958.

214. Szabo C, Billiar TR. Novel roles of nitric oxide in hemorrhagic shock. Shock 1999;12(1):1–9.

215. Hierholzer C, Harbrecht B, Menezes JM, et al. Essential role of induced nitric oxide in the initiation

of the inflammatory response after hemorrhagic shock. J Exp Med 1998;187(6):917–928.

216. Tzeng E, Kim YM, Pitt BR, et al. Adenoviral transfer of the inducible nitric oxide synthase gene

blocks endothelial cell apoptosis. Surgery 1997;122(2):255–263.

217. Nakahira K, Kim HP, Geng XH, et al. Carbon monoxide differentially inhibits TLR signaling

pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med

2006;203(10):2377–2389.

218. Li T, Zhao B, Wang C, et al. Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in

the plasma and pulmonary tissue of rats with acute lung injury. Exp Biol Med (Maywood)

2008;233(9):1081–1087.

219. Li J, Zhang G, Cai S, et al. Effect of inhaled hydrogen sulfide on metabolic responses in

anesthetized, paralyzed, and mechanically ventilated piglets. Pediatr Crit Care Med 2008;9(1):110–

112.

220. Mok YY, Atan MS, Ping CY, et al. Role of hydrogen sulphide in haemorrhagic shock in the rat:

protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 2004;143(7):881–

889.

221. Collin M, Thiemermann C. Hydrogen sulfide and sulfite: novel mediators in the pathophysiology of

shock and inflammation. Shock 2005;24(6):595–596.

222. Zhang H, Zhi L, Moochhala SM, et al. Endogenous hydrogen sulfide regulates leukocyte trafficking

in cecal ligation and puncture-induced sepsis. J Leukoc Biol 2007;82(4):894–905.

223. Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory

cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway. J Leukoc Biol

2007;81(5):1322–1332.

224. Oh GS, Pae HO, Lee BS, et al. Hydrogen sulfide inhibits nitric oxide production and nuclear factorkappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with

lipopolysaccharide. Free Radic Biol Med 2006;41(1):106–119.

225. Kimbrell DA, Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet

2001;2(4):256–267.

226. Medzhitov R, Janeway C Jr. Innate immune recognition: mechanisms and pathways. Immunol Rev

2000;173:89–97.

227. Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol

2007;81(1):1–5.

228. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature

2004;430(6996):257–263.

229. Triantafilou M, Triantafilou K. Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation

cluster. Trends Immunol 2002;23(6):301–304.

230. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:

mutations in Tlr4 gene. Science 1998;282(5396):2085–2088.

231. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4(7):499–511.

232. Roach JC, Glusman G, Rowen L, et al. The evolution of vertebrate Toll-like receptors. Proc Natl

Acad Sci U S A 2005;102(27):9577–9582.

233. Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol

2003;15(4):396–401.

231

http://surgerybook.net/

234. Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat

Immunol 2004;5(10):975–979.

235. Mack KD, Von Goetz M, Lin M, et al. Functional identification of kinases essential for T-cell

activation through a genetic suppression screen. Immunol Lett 2005;96(1):129–145.

236. Schmidt AM, Yan SD, Yan SF, et al. The multiligand receptor RAGE as a progression factor

amplifying immune and inflammatory responses. J Clin Invest 2001;108(7):949–955.

237. Stern D, Yan SD, Yan SF, et al. Receptor for advanced glycation endproducts: a multiligand receptor

magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev 2002;54(12):1615–1625.

238. Stebbing J, Bower M, Gazzard B, et al. The common heat shock protein receptor CD91 is upregulated on monocytes of advanced melanoma slow progressors. Clin Exp Immunol

2004;138(2):312–316.

239. Binder RJ, Han DK, Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol

2000;1(2):151–155.

240. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells:

chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 2002;20:395–425.

241. Basu S. Binder RJ, Suto R, et al. Necrotic but not apoptotic cell death releases heat shock proteins,

which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int

Immunol 2000;12(11):1539–1546.

242. Binder RJ, Srivastava PK. Essential role of CD91 in re-presentation of gp96-chaperoned peptides.

Proc Natl Acad Sci U S A 2004;101(16):6128–6133.

243. Melcher A, Todryk S, Hardwick N, et al. Tumor immunogenicity is determined by the mechanism

of cell death via induction of heat shock protein expression. Nat Med 1998;4(5):581–587.

244. Zheng H, Dai J, Stoilova D, et al. Cell surface targeting of heat shock protein gp96 induces

dendritic cell maturation and antitumor immunity. J Immunol 2001;167(12):6731–6735.

245. Heilmann HP, Doppelfeld E, Fernholz HJ, et al. [Results of radiotherapy of bronchial carcinoma

(author’s transl)]. Dtsch Med Wochenschr 1976;101(43):1557–1562.

246. Becker T, Hartl FU, Wieland F. CD40, an extracellular receptor for binding and uptake of Hsp70-

peptide complexes. J Cell Biol 2002;158(7):1277–1285.

247. Binder RJ, Vatner R, Srivastava P. The heat-shock protein receptors: some answers and more

questions. Tissue Antigens 2004;64(4):442–451.

248. Asea A, Kraeft SK, Kurt-Jones EA, et al. HSP70 stimulates cytokine production through a CD14-

dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med

2000;6(4):435–442.

249. Vabulas RM, Ahmad-Nejad P, da Costa C, et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2)

and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J

Biol Chem 2001;276(33):31332–31339.

250. Klionsky DJ. Autophagy. Curr Biol 2005;15(8):R282–R283.

251. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science

2000;290(5497):1717–1721.

252. Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation.

Curr Opin Cell Biol 2009;22(2):124–131.

253. Swanson MS, Molofsky. Autophagy and inflammatory cell death, partners of innate immunity.

Autophagy 2005;1(3):174–176.

254. Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct

phosphorylation of Ulk1. Nat Cell Biol 2011;13(2):132–141.

255. Hoyer-Hansen M, Jaattela M. AMP-activated protein kinase: a universal regulator of autophagy?

Autophagy 2007;3(4):381–383.

256. He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet

2009;43:67–93.

257. Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ

2005;12(suppl 2):1542–1552.

258. Wang CW, Klionsky DJ. The molecular mechanism of autophagy. Mol Med 2003;9(3–4):65–76.

259. Diaz-Troya S, Pérez-Pérez ME, Florencio FJ, et al. The role of TOR in autophagy regulation from

232

http://surgerybook.net/

yeast to plants and mammals. Autophagy 2008;4(7):851–865.

260. Meley D, Bauvy C, Houben-Weerts JH, et al. AMP-activated protein kinase and the regulation of

autophagic proteolysis. J Biol Chem 2006;281(46):34870–34879.

261. Xu Y, Jagannath C, Liu XD, et al. Toll-like receptor 4 is a sensor for autophagy associated with

innate immunity. Immunity 2007;27(1):135–144.

262. Xu Y, Liu XD, Gong X, et al. Signaling pathway of autophagy associated with innate immunity.

Autophagy 2008;4(1):110–112.

263. Hoyer-Hansen M, Bastholm L, Szyniarowski P, et al. Control of macroautophagy by calcium,

calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 2007;25(2):193–205.

264. Delgado M, Singh S, De Haro S, et al. Autophagy and pattern recognition receptors in innate

immunity. Immunol Rev 2009;227(1):189–202.

265. Delgado MA, Deretic V. Toll-like receptors in control of immunological autophagy. Cell Death Differ

2009;16(7):976–983.

266. Xu Y, Eissa NT. Autophagy in innate and adaptive immunity. Proc Am Thorac Soc 2010;7(1):22–28.

267. Waltz P, Carchman EH, Young AC, et al. Lipopolysaccaride induces autophagic signaling in

macrophages via a TLR4, heme oxygenase-1 dependent pathway. Autophagy 2011;7(3):315–320.

268. Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol 2005;26(10):523–528.

269. Nakagawa I, Amano A, Mizushima N, et al. Autophagy defends cells against invading group A

Streptococcus. Science 2004;306(5698):1037–1040.

270. Paludan C, Schmid D, Landthaler M, et al. Endogenous MHC class II processing of a viral nuclear

antigen after autophagy. Science 2005;307(5709):593–596.

271. Carchman EH, Rao J, Loughran PA, et al. Heme oxygenase-1 mediated autophagy protects against

hepatocyte cell death and hepatic injury from infection/sepsis. Hepatology 2011;53(6):2053–2062.

272. Wu H, Chen G, Wyburn KR, et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J

Clin Invest 2007;117(10):2847–2859.

273. Carchman EH, Whelan S, Loughran P, et al. Experimental sepsis-induced mitochondrial biogenesis

is dependent on autophagy, TLR4, and TLR9 signaling in liver. FASEB J 2013;27(12):4703–4711.

274. Howell GM, Gomez H, Collage RD, et al. Augmenting autophagy to treat acute kidney injury

during endotoxemia in mice. PloS One 2013;8(7):e69520.

275. Guo L, Stripay JL, Zhang X, et al. CaMKIα regulates AMP kinase-dependent, TORC-1-independent

autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. J Immunol

2013;190(7):3620–3628.

276. Evankovich J, Zhang R, Cardinal JS, et al. Calcium/calmodulin-dependent protein kinase IV limits

organ damage in hepatic ischemia/reperfusion injury through induction of autophagy. Am J Physiol

Gastrointest Liver Physiol 2012;303(2):G189–G198.

277. Zhang X, Howell GM, Guo L, et al. CaMKIV-dependent preservation of mTOR expression is

required for autophagy during LPS-induced inflammation and acute kidney injury. J Immunol

2014;193(5):2405–2415.

278. Kimura T, Takabatake Y, Takahashi A, et al. Autophagy protects the proximal tubule from

degeneration and acute ischemic injury. J Am Soc Nephrol 2011;22(5):902–913.

279. Zhang J, Randall MS, Loyd MR, et al. Mitochondrial clearance is regulated by Atg7-dependent and -

independent mechanisms during reticulocyte maturation. Blood 2009;114(1):157–164.

280. Mortensen M, Ferguson DJ, Edelmann M, et al. Loss of autophagy in erythroid cells leads to

defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A

2010;107(2):832–837.

281. Cali T, Ottolini D, Negro A, et al. Enhanced parkin levels favor ER-mitochondria crosstalk and

guarantee Ca(2+) transfer to sustain cell bioenergetics. Biochim Biophys Acta 2013;1832(4):495–

508.

282. Amadoro G, Corsetti V, Florenzano F, et al. Morphological and bioenergetic demands underlying

the mitophagy in post-mitotic neurons: the pink-parkin pathway. Front Aging Neurosci 2014;6:18.

283. Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of

mitochondria. Cell Death Differ 2013;20(1):31–42.

284. Springer W, Kahle PJ. Regulation of PINK1-Parkin-mediated mitophagy. Autophagy 2011;7(3):266–

233

http://surgerybook.net/

278.

285. Wang Y, Nartiss Y, Steipe B, et al. ROS-induced mitochondrial depolarization initiates

PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 2012;8(10):1462–

1476.

286. Polla BS, Bachelet M, Dall’ava J, et al. Heat shock proteins in inflammation and asthma: Dr Jekyll

or Mr Hyde? Clin Exp Allergy 1998;28(5):527–529.

287. Polla BS, Bachelet M, Elia G, et al. Stress proteins in inflammation. Ann N Y Acad Sci 1998;851:75–

85.

288. Multhoff G, Botzler C. Heat-shock proteins and the immune response. Ann N Y Acad Sci

1998;851:86–93.

289. Perdrizet GA. Heat shock and tissue protection. New Horiz 1995;3(2):312–320.

290. Mathew A, Morimoto RI. Role of the heat-shock response in the life and death of proteins. Ann N Y

Acad Sci 1998;851:99–111.

291. Ribeiro SP, Villar J, Slutsky AS. Induction of the stress response to prevent organ injury. New Horiz

1995;3(2):301–311.

292. Garcia-Cardena G, Fan R, Shah V, et al. Dynamic activation of endothelial nitric oxide synthase by

Hsp90. Nature 1998;392(6678):821–824.

293. Wong HR, Ryan M, Wispe JR. Stress response decreases NF-kappaB nuclear translocation and

increases I-kappaBalpha expression in A549 cells. J Clin Invest 1997;99(10):2423–2428.

294. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997;181(3):257–266.

295. Pepys MB, ed. Acute Phase Proteins in the Acute Phase Response. New York: Springer-Verlag; 1989.

296. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J

Med 1999;340(6):448–454.

297. Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta

1996;1317(2):84–94.

298. Giraldez RR, Panda A, Xia Y, et al. Decreased nitric-oxide synthase activity causes impaired

endothelium-dependent relaxation in the postischemic heart. J Biol Chem 1997;272(34):21420–

21426.

299. Romson JL, Hook BG, Kunkel SL, et al. Reduction of the extent of ischemic myocardial injury by

neutrophil depletion in the dog. Circulation 1983;67(5):1016–1023.

300. Vedder NB, Winn RK, Rice CL, et al. A monoclonal antibody to the adherence-promoting leukocyte

glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and

resuscitation in rabbits. J Clin Invest 1988;81(3):939–944.

301. Agostoni A, Gardinali M, Frangi D, et al. Activation of complement and kinin systems after

thrombolytic therapy in patients with acute myocardial infarction. A comparison between

streptokinase and recombinant tissue-type plasminogen activator. Circulation 1994;90(6):2666–

2670.

302. Morgan BP. Complement membrane attack on nucleated cells: resistance, recovery and non-lethal

effects. Biochem J 1989;264(1):1–14.

303. Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine

Consensus Conference definitions of the systemic inflammatory response syndrome and allied

disorders in relation to critically injured patients. Crit Care Med 1997;25(11):1789–1795.

304. Bone RC. Sepsis, sepsis syndrome, and the systemic inflammatory response syndrome (SIRS).

Gulliver in Laputa. JAMA 1995;273(2):155–156.

305. Rangel-Frausto MS, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory

response syndrome (SIRS). A prospective study. JAMA 1995;273(2):117–123.

306. Davies MG, Hagen PO. Systemic inflammatory response syndrome. Br J Surg 1997;84(7):920–935.

307. Dvorak HF, Galli SJ, Dvorak AM. Cellular and vascular manifestations of cell-mediated immunity.

Hum Pathol 1986;17(2):122–137.

234